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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 2 | Glial changes following an excitotoxic lesion in the CNS astroctes 显示文摘 | Dusart I Marty S Peschanski M | 1991 | Neuroscience1991，45，3： | 2 |
| 3 | Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia显示文摘 | Marti HJ Bernaudin M Bellail A | 2000 | Am J Pathol2000，156，3： | 2 |
| 4 | 中国甘肃省中铺地区下白垩统河口群的兽脚类与蜥脚类足迹组合(英文)显示文摘近年来,中国西北部兰州-民和盆地的中铺地区河口群发现了一批恐龙骨骼化石和足迹化石。中铺地区的蜥脚类与兽脚类足迹组合相对丰富,但大多数标本保存较差。大夏足迹点发现了保存较好的类似亚洲足迹的跷脚龙类足迹(Asianopodus-like grallatorid tracks),足迹有着中趾弱前凸(weak mesaxony)。李家沟一号点的足迹组合包括了较大的兽脚类足迹和大型的、非三趾型四足类足迹,后者可能是蜥脚类足迹。李家沟二号点的足迹为多层的蜥脚类足迹,这表明了这类恐龙的活跃性,巨龙类的骨骸也可能来自同一层位。虽然中铺足迹组合不如同属河口群的盐锅峡足迹组合那么具有多样化与得以充分暴露,但依然体现了该地区以及中国早白垩世地层的典型足迹组合。 | 邢立达 李大庆 Lockley M G 张建平 尤海鲁 Klein H Marty D Persons IV W S 彭措 | 2014 | 古生物学报2014，53，3： | 2 |
| 5 | Mechanism of the citrate transporters in carbohydrate and citrate cometabolism in Lactococcus and Leuconostoc species显示文摘 | BANDELL M LHOTTE M E MARTY TEYSSET C | 1998 | Appl Environ Microbiol1998，64，： | 2 |
| 6 | Neurons and astrocytes express EPO mRNA: oxygen - sensing mechanisms that involve the redoxstate of the brain 显示文摘 | Bernaudin M Bellail A Marti HH | 2000 | Glia2000，30，3： | 1 |
| 7 | Fundamentals of Scatter Search and Path Relinking 显示文摘 | Glover F Laguna M Marti R | 2000 | Control and Cybernetics (S0324-8569)2000，29，3： | 1 |
| 8 | Hypoxia induced VEGF expression precedes neovascularization after cerebral ischemia显示文摘 | Bernaudin M Bellail A | 2000 | Am J Pathol2000，156，： | 1 |
| 9 | Neutron Irradiation Effects on Optical Absorption of KU1 and KS-4V Quartz Glasses and Infrasi1301显示文摘 | Leon M Marti n P Vila R | 2009 | Fusion Engineering and Design2009，84，71819110111： | 1 |
| 10 | Proton shock acceleration in laser-plasma interactions显示文摘 | Silva L O Marti M Davies J R | 2004 | Phys Rev Lett2004，92，01： | 1 |
| 11 | Letrozole, a new potent, selective aromatase inhibitor superior to aminoglutethimide (AG) in postmenopausal women with advanced breast cancer previously treated with antiestrogens显示文摘 | Marty M Gershanovich M Campos B | 1997 | Proc AM Soc Clin Oncol1997，16，： | 1 |
| 12 | Optimization of millimeter-wave signal generation through FM-IM conversion in chirped fiber gratings 显示文摘 | Marti J Fuster J M Ramos F | 2000 | Microwave and Optical Technology Letters2000，27，6： | 1 |
| 13 | A confocal microscopy analysis of the spindle and chromosome configurations of human oocytes cryopreserved at the germinal vesicle and metaphase Ⅱ stage 显示文摘 | Boiso I Marti M Santalo J | 2002 | Hum Reprod2002，17，7： | 1 |
| 14 | Hypoxia-induced vascular endotheliad growth factor expression precedes neovasculariZation after cerebral ischemia显示文摘 | Marti H J Bemaudin M Bellail A | 2000 | J AM J Pathol2000，156，3： | 1 |
| 15 | An environmentalstudy by factor analysis of surface seawaters in the gulf ofValencia(Western Mediterranean)显示文摘 | Morales M M Marti P Llopis A | 1999 | Anal Chim Acta1999，394，： | 1 |
| 16 | Comparison of the 5-hydroxytryptamine 3 ( serotonin ) antagonist ondansetron (GR38032F) with high-dose metoclopramide in the control of cisplatin-induced emesis显示文摘 | MARTY M POUILLART P SCHOLL S | 1990 | N Engl J Med1990，322，12： | 1 |
| 17 | Acute lower intes- tinal bleeding: feasibility and diagnostic performance of CT angiography显示文摘 | Marti M Artigas JM Garzon G | 2012 | Radiology2012，262，1： | 1 |
| 18 | Endothelialdysfunction, arterial stifTness, and heart failure显示文摘 | Marti C N Ghcorghiade M Kalogeropoulos A H | 2012 | J Am Coll Cardiol2012，60，16： | 1 |
| 19 | Multicenter randomized phase Ⅲ study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy显示文摘 | Marty M Espie M Llombart A | 2006 | Ann Oncol2006，17，4： | 1 |
| 20 | Transurethral resection of prostate: technical progress and clinical experience using the bipolar Gyrus plasmakinetic tissue management system显示文摘 | Martis G Cardi A Massimo D Omhres M Mastrangeli B | 2008 | Surg Endosc2008，22，： | 1 |
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