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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Cultivation-Independent Analysis of the Development of the Lactobacillus spp.Community in the Intestinal Tract of Newborn Piglets显示文摘Molecular diversity and development of the Lactobacillus community in the intestinal tract, as influenced by age and intestinal compartment, were studied in one litter of 12 conventionally raised piglets. Piglets were euthanized at each week (3 animals per time). Digesta and tissue samples from stomach, duodenum, jejunum, ileum, caecum, colon, and rectum were collected and analysed by using 16S ribosomal RNA-based methods. DGGE (denaturing gradient gel electrophoresis) profiles revealed that the Lactobacillus communities throughout the GI tract from duodenum to rectum showed good stability at same age. This indicates that fecal Lactobacillus communities can effectively represent the intestinal community. Two dominant bands were found in tissue samples of the small intestine, suggesting that the lactobacilli can adhere to the small intestinal wall. The Lactobacillus communities in different GI tract compartments developed over time. A successional change of Lactobacillus communities was observed from birth, through creep feeding to one week after weaning, showing a trend from simple to complex and back to simple. Furthermore, a clone library of Lactobacillus spp. 16S rRNA gene sequences were generated from jejunal and colonic chymes. Six dominant DGGE bands generated from jejunal chymes were matched with sequences that show 94-98% similarity to the bands derived from L. reuteri, L. delbrueckii, and L. crispatus. Seven dominant DGGE bands generated from colon chymes were matched with sequences that show 88-99% similarity to those derived from L. reuteri, L. delbrueckii, L. amylovorus/L. sobrius, and L. acidophilus. Amplicons related to L. reuteri were found in all DGGE fingerprints from jejunal digesta of age of weeks 1, 3, and 4. Amplicons related to L. amylovorus/L. sobrius were present in all DGGE fingerprints from colonic digesta of age of week 1, 3, and 4. Amplicons related to L. delbrueckii were found before weaning, L. crispatus after creep feeding before weaning and L. acidophilus after weaning. This indicates that L. reuteri and L. amylovorus/L. sobrius probably belong to the permanent composition, while L. delbruckii, L. acidophilus, and L. crispatus probably belong to the temporal groups of Lactobacillus communities in the GI tract of piglets. | YAO Wen ZHU Wei-yun Hauke Smidt Martin W A Verstegen | 2011 | Agricultural Sciences in China2011，10，3： | 7 |
| 3 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 4 | 热浸镀锌超高强钢板钒微合金化技术研究显示文摘对超高强度钢板进行热处理,模拟热浸镀锌和合金化镀锌工艺的热循环,并考察获得的力学性能和微观组织。研究用钢含有适量的碳(~0.2%)、锰(1.2%)和铬(0.4%),保证钢板在奥氏体化后在镀锌前的连续退火线上进行快速冷却时能够完全转变成马氏体。采用不同的钒含量(0~0.1%)和氮含量(0.002%~0.012%),研究这些微合金化元素对回火马氏体强度的影响。尤其与高氮相配合情况下,钒有助于抵抗回火效应,因此在镀锌后大部分原始强化贡献被保留下来,使得钢的抗拉强度超过1 000 MPa。使用铝或硅进行不同脱氧试验,发现在同一碳含量下两者具有相同的强度水平,但是Si镇静钢的弯曲性能明显优异。对退火钢板进行微观组织观察,但是钒产生有益作用的原因还未完全掌握。通过研究得出这样结论:钒微合金化对耐腐蚀超高强度钢板的开发而言是一种极具前景的途径。 | Hutchinson B Martin D Karlsson O Lindberg F Thoors H Marceau R K W Taylor A S | 2016 | 钢铁钒钛2016，37，6： | 2 |
| 5 | Non-fusion instrumentation of the lumbar spine with a hinged pedicle screw rod system:an in vitro experiment显示文摘 | Schmoelz W Onder U Martin A | 2009 | Eur Spine J2009，18，10： | 1 |
| 6 | Production ofdigestive enzymes along the gut of the giant keyhole limpet Megathura crenulata (Mollusca: Vetigastro- poda) 显示文摘 | Martin G G Martin A Tsai W | 2011 | Comp Bioehem Physiol A2011，160，3： | 1 |
| 7 | Emergy evaluation of the performance and sustainability of three agricultural systems with different scales and management显示文摘 | Martin J F Diemont S A W Powell E Stanton M Levy-Tacher S | 2006 | Agriculture Ecosystems&Environment2006，115，14： | 1 |
| 8 | High invertase activity in tomato reproductive organs correlates with enhanced sucrose import into, and heat tolerance of, young fruit 显示文摘 | Li Z Palmer W M Martin A P | 2012 | Joumal of Experimental Botany2012，63，3： | 1 |
| 9 | Adaptivemultivariate statistical process control for monitoringtime-varying processes 显示文摘 | CHOI S W MARTIN E B MORRIS A J | 2006 | Industrial and EngineeringChemistry Research2006，45，9： | 1 |
| 10 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 11 | Antioxidant capacity,vitamine C, phenolics, and anthocyanins after storage of small fruits显示文摘 | Kalt W Forney CF Martin A | 1999 | Journal of Agricultural and Food Chemistry1999，47，： | 1 |
| 12 | Hepatocyte growth factor modulates vascular endothelial cadherin expression in human endothelial cells显示文摘 | MARTIN T A MANSEL R JIANG W G | 2001 | Clin Cancer Res2001，7，： | 1 |
| 13 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 14 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 15 | Effect of arbuscular mycorrhizal(AM) fungal communities on growth of 'Volkamer' lemon in continually moist or periodically dry soil显示文摘 | FIDELIBUS M W MARTIN C A WRIGHT G C | 2000 | Scientia Horticulturae2000，84，1： | 1 |
| 16 | Rosiglitazone,an ag- onist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats:role of oxygen free radicals generation显示文摘 | Villegas l Martin A R Toma W | 2004 | Eur J Phar- macol2004，505，： | 1 |
| 17 | N-acyl homoserine lactone binding to the CarR receptor determines quorumsensing specificity in Erwinia 显示文摘 | Martin W Daniel E T Neil A | 2000 | EMBO J2000，1999，4： | 1 |
| 18 | Crystallization-induced reactions of copolymers: I , Ring-sized isomerization of poly(ester acetals)显示文摘 | Lenz R W Martin E Schuler A N | 1973 | J Polym Sci Polym Chem1973，11，： | 1 |
| 19 | Injury-induced apoptssis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax显示文摘 | MARTIN L J KAISER A YU J W | 2001 | J Comp Neurol2001，433，3： | 1 |
| 20 | The composition of octopus renal fluid I Inorganic constitution显示文摘 | Emmanuel C F Martin A W | 1956 | Z vergl Physiol1956，39，： | 1 |
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