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| 1 | Current trends in management of hepatitis B virus reactivation in the biologic therapy era显示文摘Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk ofHBV reactivation is heightened by the use monoclonalantibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and longlasting immunosuppression. Emerging data indicatethat HBV reactivation could also develop following theuse of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is di-agnosed, it is mandatory to suspend biologic treatmentand start antiviral agents immediately. However, preemptive antiviral therapy prior to monoclonal antibodyadministration is crucial in preventing HBV reactivationand its clinical consequences. Several lines of evidencehave shown that risk of HBV reactivation is greatlyreduced by the identifi cation of high-risk patients andthe use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists. | Claudio M Mastroianni Miriam Lichtner Rita Citton Cosmo Del Borgo Angela Rago Helene Martini Giuseppe Cimino Vincenzo Vullo | 2011 | World Journal of Gastroenterology2011，17，34： | 12 |
| 2 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 3 | Plasmonic-enhanced two-photon fluorescence with single gold nanoshell显示文摘Single gold nanoshell with mutilpolar plasmon resonances is proposed to enhance two-photon fluorescence efficiently.The single emitter single nanoshell configuration is studied systematically by employing the finite-difference time-domain method.The emitter located inside or outside the nanoshell at various positions leads to a significantly different enhancement effect.The fluorescent emitter placed outside the nanoshell can achieve large fluorescence intensity given that both the position and orientation of the emission dipole are optimally controlled.In contrast,for the case of the emitter placed inside the nanoshell,it can experience substantial two-photon fluorescence enhancement without strict requirements upon the position and dipole orientations.Metallic nanoshell encapsulating many fluorescent emitters should be a promising nanocomposite configuration for bright two-photon fluorescence label.The results provide a comprehensive understanding about the plasmonic-enhanced two-photon fluorescence behaviors,and the nanocomposite configuration has great potential for optical detecting,imaging and sensing in biological applications. | ZHANG TianYue LU GuoWei SHEN HongMing Perriat P Martini M Tillement O GONG QiHuang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 2 |
| 4 | Best approach for prostate cancer detection: a prospective study on transperineal versus transrectal six-core prostate biopsy显示文摘 | P Emiliozzi A Corsetti B Tassi G Federico M Martini V Pansadoro | 2003 | Urology2003，，： | 2 |
| 5 | Wildtype BRAF is required for response to panitumumab or eetuximah in metastatic colorectal cancer 显示文摘 | Di Nicolantonio F Martini M Molinarl F | 2008 | J Clin Oncol2008，26，35： | 1 |
| 6 | Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer显示文摘 | Di Nicolantonio F Martini M Molinari F | 2008 | J Clin Oneol2008，26，35： | 1 |
| 7 | Simian virus 40 sequences and expression of the viral large T antigen oneoprotein in human pleomorphie adenomas of parotid glands 显示文摘 | Martinelli M Martini F Rinaldi E | 2002 | Am J Pathol2002，161，4： | 1 |
| 8 | Association between serum carcinoembryonie antigen and endothelial cell adhesionmolecules in colorectal cancer显示文摘 | Roselli M Guadagni F Martini F | 2003 | Oncology2003，65，2： | 1 |
| 9 | Activated Vgamma9Vdelta2Tcells trigger granulocyte functions via MCP-2release显示文摘 | Agrati C Cimini E Sacchi A Bordoni V Gioia C Casetti R Turchi F Tripodi M Martini F | 2009 | J Immunol2009，182，1： | 1 |
| 10 | Wild-type BRAF is required for responseto panitumurnab or cetuximab in metastatic colorectal cancer显示文摘 | DI NICOLANTONIO F MARTINI M MOLINARI F | 2008 | J Clin Oncol2008，26，35： | 1 |
| 11 | Coagulation and cancer:impli- cation for diagnosis and management显示文摘 | Loreto MF De Martinis M Corsi MP | 2000 | Pathol Oncol Res2000，6，： | 1 |
| 12 | Effect of extracorporeal shock wave therapy on osteoblast like ceils 显示文摘 | Martini L Giavaresi G Fini M | 2003 | Clin Orthop Relat Res2003，413，： | 1 |
| 13 | PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR- targeted monoclonal antibodies显示文摘 | SARTORE-BIANCHI A MARTINI M MOLINARI F | 2009 | Cancer Res2009，69，5： | 1 |
| 14 | Different STAT-3 andSTAT-5 phosphorylation discriminates among Ph-negative chronic myeloproliferative diseases and is independent of the V617F JAK-2 mutation显示文摘 | Teofili L Martini M Cenci T | 2007 | Blood2007，110，1： | 1 |
| 15 | Identification of mi- crobial and thermogenic gas components from Upper Devonian black shale cores,Illinois and Michigan basins显示文摘 | Martini A M Walter L M Mclntosh J C | 2008 | AAFG Bul- letin2008，92，3： | 1 |
| 16 | Sensory characteristics end functionality of sonicated whey显示文摘 | MARTINI S WALSH M | 2012 | Food Research International2012，49，2： | 1 |
| 17 | Multiple primary lung cancers显示文摘 | Martini N Melamed M R | 1975 | J Thorae Cardiovase Surg1975，70，4： | 1 |
| 18 | Determination of wax concentra- tion in sunflower seed oil 显示文摘 | MARTINI S ANON M C | 2000 | J Am Oil Chem Soc2000，77，10： | 1 |
| 19 | High incidentce of BK virus large-T-antigen-coding sequences in normal human tissue and tumors of different histotypes显示文摘 | De Mattei M Martini F Corallini A | 1995 | Int J ancer1995，61，6： | 1 |
| 20 | PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies 显示文摘 | Sartore-Bianchi A Martini M Mollnari F | 2009 | Cancer Res2009，69，5： | 1 |
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