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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 3 | Distribution of beta-glucanases within the genus Bacillus 显示文摘 | Martin D F Priest F G Todd C | 1980 | Appl Environ Microbiol1980，40，6： | 1 |
| 4 | Base-pair neutral homozygotes can be discriminated by calibrated high-resolution melting of small amplicons显示文摘 | Gundry C N Dobrowolski S F Martin Y R | 2008 | Nucleic Acids Res2008，36，： | 1 |
| 5 | CuInSe2thin films grown by MOCVD: characterization, first devices 显示文摘 | Artaud M C Ouchen F Martin L | 1998 | Thin solid films1998，324，： | 1 |
| 6 | Comb filters based on superstructure rocking filters in photosensitive optical fibers 显示文摘 | Psaila D C Martin C Ouellette F | 1997 | Optics communications1997，141，： | 1 |
| 7 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 8 | CuInSe2 thin films grown by MOCVD= Characterization, {irst devices 显示文摘 | Artaud M C Ouchen F Martin L | 1998 | Thin solid films1998，324，： | 1 |
| 9 | Effect of a prepartum administration of monensin in a controlled-release capsule on apparent digestibilities and nitrogen utilization in transition dairy cows显示文摘 | Plaizier J C Martin A Duffield T F | | 0，，12： | 1 |
| 10 | Follow up studies on therespiratory pattern and total cholinesterase activities in dichlorvos-poisoned rats显示文摘 | Duarte T Martin C Baud F Jf | 2012 | Toxicoly Lett2012，213，2： | 1 |
| 11 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 12 | Synthesis and oxidation reactions of cycloheptatrienyl sulfones显示文摘 | Zhiwei T Yuahong C Martin F | 2000 | Tetrahedron Lett2000，41，41： | 1 |
| 13 | Spray characteristics of aerated liquid pressure atomizers 显示文摘 | Lefebvre A H Wang X F Martin C A | 1988 | AIAA J Prop Power1988，4，4： | 1 |
| 14 | Sulfuric activation of a brazilian manganese ore for heavy metals removal显示文摘 | RESENDE P C BARRADO F S MARTINS A H | 1999 | Hydrometallurgy1999，51，3： | 1 |
| 15 | Random sample consensus: A paradigm for model fitting with application to image analysis and automated cartography显示文摘 | Martin A F Robert C B | 1981 | Communications of the ACM:Graphics and Image Processing1981，24，6： | 1 |
| 16 | An algorithm for the k-error linear complexity of binary sequences of period 2^n显示文摘 | Stamp M Martin C F | 1993 | IEEE Trans on Information Theory1993，39，4： | 1 |
| 17 | Thermally assisted recording beyond traditional limits 显示文摘 | HAMANN H F MARTIN Y C WICKRAMASINGHE H K | 2004 | Ap- pl Phys Let2004，84，： | 1 |
| 18 | Pitting corrosion of welded joints of austenitic stainless steels studied by using an electrochemical minicell显示文摘 | GARCIA C MARTIN F TIEDRA P D | 2008 | Corro- sion Science2008，50，： | 1 |
| 19 | Multistage expansion planning for active distribution networks under demand and distributed generation uncertainties显示文摘 | BORGES C L T MARTINS V F | 2012 | International Journal of Electrical Power Energy Systems2012，36，1： | 1 |
| 20 | The composition of octopus renal fluid I Inorganic constitution显示文摘 | Emmanuel C F Martin A W | 1956 | Z vergl Physiol1956，39，： | 1 |
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