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| 1 | Cachexia and pancreatic cancer: Are there treatment options?显示文摘Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAC)and is associated with reduced survival and quality of life.Unfortunately,the therapeutic options of this multi-factorial and complex syndrome are limited.This is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood.Furthermore,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature.In order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese patients.Although many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia.However,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’outcome.In this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients.This strategy consists of nutritional,dietary,pharmacological,physical and psychological methods. | Tara C Mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 2 | Plasma homocysteine and L-DOPA metabolism in patients with Parkinson disease显示文摘 | Blandini F Fancellu R Martignoni E | 2001 | Clin Chem2001，47，6： | 1 |
| 3 | Naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study 显示文摘 | Sances G Martignoni E Fioroni L | 1990 | Headache1990，30，： | 1 |
| 4 | A crossover, controlled stud ycomparing pergolide with bromocriptine as an adjunct to levodopa for the treat mentof Parkinson's disease显示文摘 | Martignoni E Pacchett C | 1995 | Neurology1995，45，3： | 1 |
| 5 | Deter- mination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection显示文摘 | BLANDINI F MARTIGNONI E RICOTTI R | 1999 | Journal of Chroma- tography B1999，732，： | 1 |
| 6 | Simultaneous determination of L - dopaand 3 - 0 - methyldopa in human platelets and plasma using high - performance liquidchromatography with electrochemical detection显示文摘 | Blandini F Martignoni E Pacchetti C | 1997 | Journal of Chromatography B1997，700，： | 1 |
| 7 | l Endorphin patterns within the headache spectrum disorders显示文摘 | Nappi G Facchinetti F Martignoni E et a | 1985 | Cephalagia1985，5，2： | 1 |
| 8 | Simultaneous determination of L-dopa and 3-O-methyldopa in human platelets and plasma using high performance liquid chromatography with electrochemical detection 显示文摘 | Blandini F Martignoni E Pacchetti C | 1997 | J Chromatogr B Biomed Sci Appl1997，700，12： | 1 |
| 9 | Monoamines and related metabolite levels in the cerebrospinal fluid of patients with dementia of Alzheimer type: Influence of treatment with L-deprenyl显示文摘 | Bono G Blandini F | 1991 | J Neurol Transm Park Dis Dement Sect1991，3，1： | 1 |
| 10 | Genotypic intratumoral heterogeneity in breast carcinoma with HER2/neu amplification : evaluation according to ASCO/CAP criteria显示文摘 | Brunelli M Manfrin E Martignoni G | 2009 | Am J Clin Pathol2009，181，5： | 1 |
| 11 | Simultaneous determination of L-dopa and 3-O-methyldopa in human platelets and plasma using high performance liquid chromatography with electrochemical detection 显示文摘 | BLANDINI F MARTIGNONI E PACCHETTI C | 1997 | J Chromatogr B Biomed Sci Appl1997，700，12： | 1 |
| 12 | Peripheral markers of oxidative stress in Parkinson's disease: The role of L-DOPA显示文摘 | Martignoni E Blandini F Godi L | 1999 | Free Radic Biol Med1999，27，34： | 1 |
| 13 | HER2/neuassessment in breast cancer using the original FDA and newASCO/CAP guide- line recommendations: impact on selecting'patients for herceptin therapy显示文摘 | Brunelli M Manfrin E Martignoni G | 2008 | Am J Clin Pathol2008，129，6： | 1 |
| 14 | Plasma and CSF endorphin levels in primary and symptomatic headache 显示文摘 | Nappi G Facchinetti F Martignoni E | 1985 | Headache1985，25，2： | 1 |
| 15 | Plasma homocysteine and L-dopa metabolism in patients with Parkinson disease显示文摘 | Blandini F Fancellu R Martignoni E | | 0，，06： | 1 |
| 16 | Parkinson's disease and reproductive life events显示文摘 | Martignoni E Nappi RE Citterio A Calandrella D Corengia E Fignon A Zangaglia R Riboldazzi G Pacchetti C Nappi G | 2002 | Neurol Sci2002，232，： | 1 |
| 17 | Changes of neuroendocrine axes in patients with menstrual migraine显示文摘 | FioronIL Martignoni E Facchinetti F | 1995 | Cephalalgia1995，15，4： | 1 |
| 18 | Premenstrual fall of plasma betaendorphin in patients with premenstrual syndrome 显示文摘 | Facchinetti F Martignoni E Petaglia F | 1987 | Fertil Steril1987，47，： | 1 |
| 19 | HER-2/neu assessment in breast cancer using the original FDA and new ASCO/CAP guideline recommendations:impact on selecting patients for herceptin therapy 显示文摘 | Brunelli M Manfrin E Martignoni G | 2008 | Am J Clin Pathol2008，129，6： | 1 |
| 20 | Effect of preoperative biliary drainage on surgical outcome after pancreas to duodenectomy 显示文摘 | MARTIGNONI E WAGNER M KRAHENBUHL L | 2001 | Am J Surg2001，181，1： | 1 |
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