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| 1 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 2 | Approximation algorithms for fixed job schedule problems显示文摘 | Fischettim Martello M S Toth P | 1992 | Operational Research1992，40，： | 1 |
| 3 | MicroRNA control of Nodal signal ling显示文摘 | Martello G Zacchigna L lnui M | 2007 | Nature2007，449，7159： | 1 |
| 4 | Optimization of a-terpineol production by the biotransformation of R- ( + )-limonene and (-)-/3-pinene 显示文摘 | Rottava I Cortina P F Martello E | 2011 | Appl Siochem Biotechnol2011，164，4： | 1 |
| 5 | Radio resource sharing for ad hoc networking with UWB显示文摘 | CUOMO F MARTELLO C BAIOCCHI A | 2002 | IEEE J Sel Areas Commun2002，20，9： | 1 |
| 6 | Heuristic algorithms for the three-dimensional bin packing problem显示文摘 | Andrea Lodi Silvano martello Daniele Vigo | 2002 | European Journal of Operational Research2002，141，： | 1 |
| 7 | MicreRNA control of signal transduc- tion显示文摘 | Inui M Martello G Piccolo S | 2010 | Nat Rev Mol Cell Biol2010，11，4： | 1 |
| 8 | MicroRNA control of sig- nal transduction显示文摘 | Inui M Martello G Piccolo S | 2010 | Nat Rev Mol Cell Biol2010，11，4： | 1 |
| 9 | MicroRNA control of signal transduction 显示文摘 | Inui M Martello G Piccolo S | 2010 | Nat Rev Mol Cell B/o/2010，11，4： | 1 |
| 10 | Last effects of MDMA on central serotonergic neurons in no human primate: neurochemical observation 显示文摘 | Ricuarte GA Martello AL Katz JL | 1992 | J Pharmacol Exp Ther1992，，261： | 1 |
| 11 | MicroRNA control of signal transduction 显示文摘 | Inui M Martello G Piccolo S | | Nat Rev Mol Cell Biol0，11，4： | 1 |
| 12 | Integration of TGF-β and Ras/MAPK signaling through P53 phosphorylation 显示文摘 | Cordenonsi M Montagner M Adorno M Zacchigna L Martello G Mamidi A | 2007 | Science2007，315，5813： | 1 |
| 13 | Combined effects of pentachlorophenol and salinity stress on phagocytic and chemotactic function in two species of abalone显示文摘 | Martello L B Friedman C S Tjeerdema R S | 2000 | Aquatic Toxicology2000，49，： | 1 |
| 14 | Approximation algorithms for the oriented two-dimensional bin packing problem 显示文摘 | LODI A MARTELLO S VIGO D | 1999 | European Journal of Operational Research1999，112，1： | 1 |
| 15 | Dynamic Programming and Strong Bounds for the 0-1 Knapsack Problem显示文摘 | Martello S Pisinger D Toth P | 1999 | Management Science1999，45，3： | 1 |
| 16 | Two-dimensional packing problems: A survey 显示文摘 | LODI A MARTELLO S MONACI M | 2002 | European Journal of Operational Research2002，141，2： | 1 |
| 17 | Dynamic programming and strong bounds for the 0- 1 knapsack problem显示文摘 | Silvano Martello David Pisinger Paolo Toth | 1999 | Management Science1999，45，3： | 1 |
| 18 | The k- cardinality assignment problem显示文摘 | Dell' Amico M Martello S | 1997 | Discrete Applied Mathematics1997，76，： | 1 |
| 19 | Optimal scheduling of tasks on identical parallel processors显示文摘 | Dell'Amico M Martello S | 1995 | ORSA Journal on Computing1995，7，： | 1 |
| 20 | MAC principles for an ultra wide band wireless access显示文摘 | CUOMO F MARTELLO C | 2001 | IEEE Global Telecommunications Conference2001，，6： | 1 |
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