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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 3 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 4 | Development of a selective enzyme- linked immunosorbent assay for 1- naphthol- the major metabolite of carbaryl(1- naphthyl n- methylcarbamate)显示文摘 | Marco M P Hammock B D | 1994 | J Agric Food Chem1994，42，4： | 1 |
| 5 | Bird communities as hioindicators: The focal species concept in agricultural land- scape 显示文摘 | Emilio P D Marco B Renato M | 2006 | Ecological Indicators2006，，6： | 1 |
| 6 | Performance of Spontaneous Phage-Resistant Derivatives of Lactobacillus Plantarum in Fermented Milk Manufacture 显示文摘 | BRIGGILER MARCO M MERCANTI D REINHEIMER J A | 2011 | International Dairy Journal2011，21，11： | 1 |
| 7 | The breeding system of Oxalis squamata,a tristylous South American species显示文摘 | Marco D E Arroyo M T K | 1998 | Botanica Acta1998，111，： | 1 |
| 8 | Psychiatric comorbility in patientswith chronic daily headache and migraine:A selective overviewincluding personality traits and suicide risk显示文摘 | Pompili M Daniela D C Marco I | 2009 | Headache Pain2009，10，4： | 1 |
| 9 | Ant colony system: a cooperative learning approach to the traveling salesman problem显示文摘 | Marco D and Gambardella L M | 1997 | IEEE Transactions on Evolutionary Computation1997，1，1： | 1 |
| 10 | Sub optimal scheduling in a grid using genetic algorithms显示文摘 | VINCENZO D M MARCO M | 2004 | Parallel Computing2004，30，56： | 1 |
| 11 | Solar space heating and cooling for Spanish housing: potential energy savings and emissions reduction 显示文摘 | Marcos J D Izquierdo M Parra D | 2011 | Solar Energy2011，85，11： | 1 |
| 12 | Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting: A Randomized Multicenter Trial显示文摘 | Marco Valgimigli Gianluca Campo Monia Monti Pascal Vranckx Gianfranco Percoco Carlo Tumscitz Fausto Castriota Federico Colombo Matteo Tebaldi Giuseppe Fucà Moh?d Kubbajeh Elisa Cangiano Monica Minarelli Antonella Scalone Caterina Cavazza Alice Frangione M | 2012 | Circulation2012，，16： | 1 |
| 13 | Fast track surgery to reduce short-term complications following radical cystectomy and intestinal urinary diversion with Vescica Ileale Padovana neobladder:proposal for a tailored enhanced recovery protocol and preliminary report from a pilot study显示文摘 | Cerruto M A De Marco V D'Elia C | 2014 | Urol Int2014，92，1： | 1 |
| 14 | Manufacturing Firm Reaction to Supplier Failure and Recovery显示文摘 | Marcos Andre Mendes P Kevin D Rungtusanatham M J | 2007 | International Journal of Operations & Production Management2007，27，3： | 1 |
| 15 | Spontaneous Lactobacillus delbrueckii phage-resistant mutants with acquired bile tolerance显示文摘 | Guglielmotti D Marco M B Vinderola C | 2007 | International Journal of Food Microbiology2007，119，： | 1 |
| 16 | Structural evolution of Eucalyptus tar pitch-based carbons during carbonization显示文摘 | MARCOS J P VANYA M D NELCY D S CHOYU O SATIKA O LUIZ C P | 2005 | Biomass Bioenergy2005，28，1： | 1 |
| 17 | Accidental removal of endotracheal and nasogastric tubes and intravascular catheters显示文摘 | Carrion MI Ayuso D Marcos M | 2000 | Crit Care Mcd2000，28，6： | 1 |
| 18 | Experimental boiling heat transfer coefficients in the high temperature generator of a double effect absorption machine for the lithium bromide/water mixture 显示文摘 | MARCOS J D IZQUIERDO M LIZARTE R PALACIOS E INFANTE F C A | 2009 | International Journal of Refrigeration2009，32，： | 1 |
| 19 | Ant system:optimization by a colony of cooperating agents显示文摘 | Marco D Vittorio M Alberto C | 1996 | IEEE Transactions on Cybernetics1996，26，1： | 1 |
| 20 | Accidental removal of endotra- cheal and nasogastric tubes and intravascular catheters 显示文摘 | Carri6n M Ayuso D Marcos M | 2000 | Crit Care Med2000，28，1： | 1 |
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