|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 3 | Extraction of ginger ( Zingiberofficinale Roscoe ) oleoresinwith CO2 andcosolvent : a study of the antioxidant action of the extracts显示文摘 | Kelly C Marcia O M | 2002 | Supercritical Fluids2002，24，： | 1 |
| 4 | Waterborne polyurethane dispersions based on hydroxyl terminated polybutaduene and poly ( propylenegly- col) synthesis and characterization显示文摘 | Femanda M B Marcia C D | 2001 | Jciumal of Applied PolymerScience2001，80，5： | 1 |
| 5 | SIRT3 Is a mitochondrial tumor suppressor:a scientific tale that connects aberrant cellular ROS,the warburg effect, and carcinogenesis 显示文摘 | Marcia C H Deng C X Lydia W S | 2012 | Cancer Research2012，72，10： | 1 |
| 6 | Waterborne anionic polyurethanes and poly(urethane-urea)s: influence of the chain extender on mechanical and adhesive properties 显示文摘 | Marcia C D Fernanda M B C | 2000 | Polymer Testing2000，19，： | 1 |
| 7 | Confocal endomicroscopy显示文摘 | KERRY B D MARCIA I C | 2010 | Techniques in Gastrointestinal Endoscopy2010，12，2： | 1 |
| 8 | Effects of diet supplementation with three soluble polysaccharides on serum lipid levels of hypercholesterolemic rats 显示文摘 | INAR A C JULIO T MARCIA L | 2003 | Food Chemistry2003，80，3： | 1 |
| 9 | Extraction of ginger (Zingiber officinale Roscoe) oleo- resin with CO2 and co-solvents: a study of the antioxidant action of the extracts 显示文摘 | Zancan Kelly C Marques Marcia O M Petenate Ademir J | 2002 | The Journal of Supercritical Fluids2002，24，1： | 1 |
| 10 | Percutaneous Vertebroplasty in Multiple, Myeloma Vertebral Involvement 显示文摘 | Masala S Anselmetti G C Marcia S | 2008 | J Spinal Disord Tech2008，21，5： | 1 |
| 11 | Amtimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in mice显示文摘 | RESENDE F A CLAVDETE A M MARCIA C | 2006 | Life Sci2006，79，5： | 1 |
| 12 | The effects of solvent and electrolyte in the surfaceenhanced raman - spectrum of Iron(Ⅱ)bis( 1,10 Phenanthroline) dicyano-evidence for the formation of strong Ion-pairs显示文摘 | PAOLA CORIO MARCIA L ATEMPERINI JOEL C RUBIM etal | | Spectrochimica Acta0，，： | 1 |
| 13 | Waterborne anionic polyurethanes and poly(urethane-urea)s:influence of the chain extender on mechanical and adhesive properties显示文摘 | Marcia C Delpech Fernanda M B Coutinho | 2000 | Polymer Testing2000，19，： | 1 |
| 14 | Thermal and mechanical profile of cast films from waterborne polyurethanes based on polyether block copolymers显示文摘 | CRISTIANE C SANTOS MARCIA C DDELPECH FERNANDA M B C | 2009 | Journal of Materials Science2009，44，5： | 1 |
| 15 | Waterborne anionic polyurethanes and poly (urethane - urea) s: influence of the chain extender on mechanical and adhesive properties 显示文摘 | Marcia C Delpech Fernanda M B Coutinho | 2000 | Polymer Testing2000，19，8： | 1 |
| 16 | Propolis antimicrobial activity against periodontopathic bacteria显示文摘 | GEBARA C E LIMA A MARCIA P A | 2002 | Braz J Microbiol2002，33，4： | 1 |
| 17 | Definition, diagnosis, and forensic implications of postconcussional syndrome显示文摘 | RYAN C W RICHRD C W MARCIA J | 2005 | Psychosomatics2005，46，： | 1 |
| 18 | Waterborne anionic polyurethanes and poly (urethaneurea)s:influence of the chain extender on mechanical and adhesive properties显示文摘 | MARCIA C DELPECH FERNANDA M B COUTINHO | 2000 | Polymer Testing2000，，19： | 1 |
| 19 | Acute pulmonary in- jury induced by experimental muscle trauma 显示文摘 | Sombra Marcia A da Silva C | 2011 | Acta cirurgica brasileira/Sociedade Brasileira para Desen- volvimento Pesquisa em Cirurgia2011，26，1： | 1 |
| 20 | The chemometric approach 显示文摘 | RUDOLF K MARCIA M C F A priori molecular descriptors in QSAR: a case of HIV-1 protease inhibitors I | 2003 | Journal of Molecular Graphics and Modeling2003，21，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员