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| 1 | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial显示文摘Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning(biMSkL) more than training under the active mode in stroke patients. Twenty-six healthy individuals(HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or CT scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. The protocol included a two-day training on a new bimanual cooperative task, LIFT-THE-TRAY, under either the active or activeassisted modes(where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan? robotic device. The hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. The biMSkL was quantified by a speed-accuracy trade-off(SAT) before(T1) and immediately after(T2) training on days 1 and 2(T3 and T4). The change in SAT after 2 days of training(T4/T1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode(T4/T1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. Taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied 'as-needed.' This study was approved by the local ethical committee(Comité d'éthique médicale, CHU UCL Namur, MontGodinne, Yvoir, Belgium;Internal number: 54/2010, Eudra CT number: NUB B039201317382) on July 14, 2016 and was registered with ClinicalTrials.gov(Identifier: NCT03974750) on June 5, 2019. | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 2 | The gluteal fasciocutaneous rotation-advancement flap with V-Y closure in the management of sacarl pressure sores显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，，： | 1 |
| 3 | The gluteal fasciocutaneous rotation-advancement flap with V-Y closure in the management of sacral pressure sores显示文摘 | Borman H Maral T | | 0，，： | 1 |
| 4 | Effectiveness of human amnion preserved long-term in glycerol as a temporary biological dressing显示文摘 | Borman H Arslan H | 1999 | Burns1999，25，7： | 1 |
| 5 | Saturation index characteristics and crystallization mechanism of hydromag ' nesite and huntite in Salda Lake, Turkey 显示文摘 | Kamisoglu T Maral M Kepekli A | 2003 | Progress in Mining and Oilfield Chemistry2003，，5： | 1 |
| 6 | Wound healing at adaptation zones of skin flaps harvested from acute burned skin显示文摘 | Akinbingol G Bonnan H Maral T | 2013 | Bums2013，39，6： | 1 |
| 7 | The gluteal fasciocutaneous rotation-advancement flap with V-Y closure in the management of sacarl pressure sores显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，114，： | 1 |
| 8 | A model for the handover traffic in low Earth-orbiting (LEO) satellite networks for personal communications 显示文摘 | Dosiere F Zein T Maral G | 1993 | International Journal of Satellite Communications1993，11，3： | 1 |
| 9 | The gluteal fasciocutaneous rotation-advance- ment flap with V-Y closure in the management of sacral pressure sores显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 10 | The use of superficial and deep par- tial - thickness burned tissue for flap fabrication显示文摘 | Borman H Maral T Bilezikci B | 2002 | Eur J Plast Surg2002，25，： | 1 |
| 11 | The gluteal fasciocutaneous rotation-advanceme nt flap with V-Y closure in the management of sacral pressure sores 显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，109，： | 1 |
| 12 | The gluteal fasciocutaneous rotation-advancement flap with V-Y closure in the management of sacarl pressure sores显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，，： | 1 |
| 13 | The gluteal fasciocutaneous rotation- advancement flap with V-Y closure in the management of sacral pressure sores 显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 14 | Technique for blepharoptosis correction using double-breasted orbicularis oculi muscle flaps显示文摘 | BORMAN H MARAL T | 2006 | Ann Plast Surg2006，57，4： | 1 |
| 15 | Saturation Index Characteristics and Crystallization Mechanism of Hydro- magnesite and Huntite in Salda Lake, Turkey 显示文摘 | Kamisogglu T Maral M Kepekli A | 2003 | Progress in Mining and Oilfield Chemistry2003，，5： | 1 |
| 16 | The use of superficial and deep partial-thickness burned tissue for flap fabrication显示文摘 | Borman H Maral T Bilezikci B | | 0，，： | 1 |
| 17 | Fingertip reconstruction using two variations of direct-flow homodigital neurovascular island flaps显示文摘 | BORMAN H MARAL T TANCER M | 2000 | Ann Plast Surg2000，45，1： | 1 |
| 18 | The gluteal fascioqutaneous ro-tation-advancement flap with V-Y closure in the management of sacral pressure sores 显示文摘 | Borman H Maral T | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 19 | The use ol superficial and deep partial-thickness burned tissue for flap fabrication 显示文摘 | BORMAN H MARAL T BILEZIKCI B | 2002 | Fur J Plast Surg2002，25，5： | 1 |
| 20 | A case of popliteal pterygium treated along with nerve expansion显示文摘 | Maral T Tuncali D Ozgür F | | 0，，01： | 1 |
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