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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Unique features and prognosis of primum ASD presenting in the first year of life显示文摘 | MANNING PB MAYER JE JR SANDERS SP | 1994 | Circulation1994，90，52： | 1 |
| 3 | Effect of modified ultra- filtration on plasma thromboxane B2, leukotriene 134, and endothe- lin-1 in infants undergoing cardiopulmonary bypass 显示文摘 | Pearl JM Manning PB McNarnara JL | 1999 | Ann Thorac Surg1999，68，4： | 1 |
| 4 | One slide fits all: the versatil- ity of slide tracheoplasty with cardiopulmonary byPASs support for airway reconstruction in children 显示文摘 | Manning PB Rutter MJ Lisec A | 2011 | J Thorac Cardiovasc Surg2011，141，1： | 1 |
| 5 | Slide tracheoplasty in infants and children:risk factors for prolonged postoperative ventilatory support显示文摘 | Manning PB Rutter MJ Border WL | 2008 | Ann Thorac Surg2008，85，4： | 1 |
| 6 | One slide fits all : the ver-satility of slide tracheoplasty with cardiopulmonary bypass support forairway reconstruction in children 显示文摘 | Manning PB Rutter MJ Lisec A | 2011 | J Thorac Cardiovasc Surg2011，141，1： | 1 |
| 7 | Rapid generation of a mouse model for Middle East respiratory syndrome 显示文摘 | Zhao J Li K Wohlford-Lenane C Agnihothram SS Fett C Zhao J Gale MJ Baric RS Enjuanes L Gallagher T McCray PB Per | 2014 | Proc Natl Acad Sci USA2014，111，13： | 1 |
| 8 | Risk of recoarctation should not be a deciding fact'or in the timing of coarctation repair 显示文摘 | Peal JM Manning PB Franklin C | 2004 | Am J Cardio12004，63，2： | 1 |
| 9 | Outcomes of the bi- directional Glenn procedure in patients less than 3 months of age 显示文摘 | Petrucci O Khoury PR Manning PB | 2010 | J Thorac Cardiovasc Surg2010，139，3： | 1 |
| 10 | Risk of recoarctation should not be a deciding factor in the timing of coarctation repair显示文摘 | Peal JM Manning PB Franklin C | 2004 | Am J Cardiol2004，63，2： | 1 |
| 11 | Slide tracheoplasty in infants and children:risk factors for prolonged postoperative ventilatory support显示文摘 | Manning PB Rutter MJ Border WL | 2008 | Ann Thorac Surg2008，85，4： | 1 |
| 12 | Outcomes of the bidirectional Glenn procedure in patients less than 3 months of age显示文摘 | Petrucei O Khoury PR Manning PB | 2010 | J Thorac Cardiovasc Surg2010，139，3： | 1 |
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