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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Analytical evaluation of askerov functions arising from anisotropy of the thermoelectric power in superlat- tices 显示文摘 | MAMEDOV B A | 2012 | Physica A:S''tatical Mechanics and its Applicantions2012，391，23： | 1 |
| 3 | On the computation of molecular auxiliary functions A n and B n显示文摘 | I I Guseinov B A Mamedov M Kara M Orbay | 2001 | Pramana2001，，5： | 1 |
| 4 | Thermally stable, highly conductive, and transparent ZnO layers prepared in situ by chemical vapor deposition 显示文摘 | Ataev B M Bagamadova A M Mamedov V V | 1999 | Mater Sei Eng B1999，65，3： | 1 |
| 5 | Intereaction of carbon dioxide with methane on oxide catalysts显示文摘 | Horiuchi T Mamedov A K Mirzabekowa S R | 1998 | Catal Today1998，42，3： | 1 |
| 6 | Oxidative dehydrogena- tion of lower alkanes on vanadium oxide-based catalysts: The present state of the art and outlooks显示文摘 | Mamedov E A Cortes Carberdn V | 1995 | Appl Catal A: Gen- eral1995，127，12： | 1 |
| 7 | 显示文摘 | Mamedov A Kh Mirzabekova S R | 1995 | Catal Today1995，24，： | 1 |
| 8 | Intereaction of carbon dioxide with methane on oxide catalysts显示文摘 | Horiuchi T Mamedov A K Mirzabekova S R | 1998 | Catal Today1998，42，3： | 1 |
| 9 | Some fundamental and practical aspects of the ammoxidation of alkylbenzenes显示文摘 | Rizayev R G Mamedov E A Vislovskii V P | 1992 | Applied Catalysis A:General1992，83，2： | 1 |
| 10 | 显示文摘 | Mamedov A Kh Mirzabekova S R | 1995 | Ind Eng Chem Res1995，34，： | 1 |
| 11 | One-pot synthesis of Agα-TiO2 core-Shell nanoparticles and their layer-by-layer assembly 显示文摘 | Pastoriza-Santos I Koktysh D S Mamedov A A | 2000 | Langmuir2000，16，6： | 1 |
| 12 | One-pot synthesis of Ag@TiO2 core-shell nanoparticles and their layer-by-layer assembly显示文摘 | Pastoriza-Santos I Koktysh D S Mamedov A A | 2000 | Langmuir2000，16，6： | 1 |
| 13 | Novel synthesis of,4-halo-3-hydroxy-2-pyrone:one pot rearrangement-cyclization reaction by magnesium halide显示文摘 | Komiyama T Takaguchi Y Gubaidullin A T Mamedov V A Litvinov I A Tsuboi S | | 0，，： | 1 |
| 14 | Improving tool-grinding conditions by variation in process kinematics显示文摘 | v MOVLA-ZADE V MAMEDOV A ALIYEV R | 2006 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2006，220，6： | 1 |
| 15 | Thermally stable, highly conductive, and transparent ZnO layers prepared in situ by chemical vapor depositiori 显示文摘 | Ataev B M Bagamadova A M Mamedov V V | 1999 | Mater Sci Eng B1999，65，3： | 1 |
| 16 | Oxidative dehydrogenation of lower alkanes on vanadium oxide-based catalysts: the present state of the art and outlooks 显示文摘 | Mamedov E A Corberán V C | 1995 | Appl Catal A: General1995，127，： | 1 |
| 17 | Wetting rate and soil texture effect on infiltration rate and runoff显示文摘 | Mamedov A I Levy G J Shainberg I | 2001 | Aust J Soil Res2001，36，： | 1 |
| 18 | Mixed MVSb oxides as oxidehydrogenation catalysts显示文摘 | MAMEDOV E A TALYSHINSKII R M RIZAYEV R G | 1996 | Catalysis Today1996，32，： | 1 |
| 19 | In2 S3 nanocolloids with excitonic emission: In2 S3 vs CdS comparative study of optical and structural characteristics 显示文摘 | Nagesha D K Liang X R Mamedov A A | 2001 | Journal of Physical Chemistry B2001，105，31： | 1 |
| 20 | Interaction of carbon dioxide with methane on oxide catalysts 显示文摘 | Krylov O V Mamedov A K Mirzabekova S R | 1998 | Catal Today1998，42，： | 1 |
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