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434篇 您的检索式：作者名="MALONE P"

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	题名	作者	年代	出处	被引量
1	术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal.	Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN	2016	中华神经外科疾病研究杂志2016，15，5：	2
2	Cost and outcome analysis of home parenteral and enteral nutrition 显示文摘	Reddy P Malone M	1998	JPEN1998，22，5：	1
3	Charge separation during the fragmentation of rime and frost 显示文摘	Saunders C P R Hickson H Malone M D Richtofen J V	1993	Atmospheric Research1993，83，：	1
4	ALK inhibitors: a new targeted therapy in the treatment of advanced NSCLC显示文摘	Casaluce F Sgambato A Malone P	2013	Target Oncol2013，8，1：	1
5	Direct gene transfer into mouse muscle in vivo 显示文摘	Wolff J A Malone R W Williams P	1990	Science1990，247，：	1
6	Direct gene transfer into mouse muscle in vivo显示文摘	Wolff J A Malone R W Williams P	1990	Science1990，247，：	1
7	Prevalence and significance of retinopathy in subjects with type 1 diabetes of less than 5 years' duration screened for the diabetes control and complications trial Diabetes Care显示文摘	Malone J I Morrison A D Pavan P R	2001	24(3):522-5262001，24，3：	1
8	Direct gene transfer into mouse muscle in vivo显示文摘	WOLFF J A MALONE R W WILLIANMS P	1990	Science1990，247，：	1
9	Direct gene transfer into mouse muscle in vivo 显示文摘	Wolff JA Malone RW Williams P	1990	Science1990，247，49491：	1
10	Direct gene transfer into mouse in vivo显示文摘	Wolff J A Malone R W Williams P	1990	Science1990，247，：	1
11	Direct gene transfer into mouse muscle in vivo显示文摘	Wolff JA Malone RW Williams P	1990	Science1990，247，3：	1
12	Phase equilibrium of ethanol fuel blends显示文摘	FRENCH R MALONE P	2005	Fluid Phase Equilibria2005，，：	1
13	Impact of HIV infection on tuberculosis显示文摘	Zulma A Malon P Henderson J	2000	Postgrad Med J2000，76，3：	1
14	Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats显示文摘	Westerlind KC Gibson KJ Malone P	1998	J Bone Miner Res1998，13，6：	1
15	Direct gene transfer intomouse muscle in vivo显示文摘	Wolff J A Malone R W Williams P	1990	Science1990，247，：	1
16	Direct gene transfer into mouse muscle in vivo 显示文摘	Malone RW Williams P	1990	Science1990，247，49491：	1
17	Direct gene transfer into mouse muscle in vivo显示文摘	Wolff JA Malone RW Williams P	1990	Science1990，24，1：	1
18	Direct gene transfer into mouse muscle in vivo显示文摘	WOLFF J A MALONE R W WILLIAMS P	1990	Science1990，2，17：	1
19	Dire6t gene transfer into mouse muscle in vivo 显示文摘	WOLFF J A MALONE R W WILLIAMS P	1990	Science1990，247，：	1
20	Direct gene transfer into mouse muscle in vivo显示文摘	Wolff JA Malone RW Williams P	1990	Science1990，247，49491：	1

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