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| 1 | Early acute kidney injury after liver transplantation: Predisposing factors and clinical implications显示文摘AIM To investigate the additional clinical impact of hepatic ischaemia reperfusion injury(HIRI) on patients sustaining acute kidney injury(AKI) following liver transplantation.METHODS This was a single-centre retrospective study of consecutive adult patients undergoing orthotopic liver transplantation(OLT) between January 2013 and June 2014. Early AKI was identified by measuring serum creatinine at 24 h post OLT(> 1.5 × baseline) or by the use of continuous veno-venous haemofiltration(CVVHF) during the early post-operative period. Patients with and without AKI were compared to identify risk factors associated with this complication. Peak serum aspartate aminotransferase(AST) within 24 h post-OLT was used as a surrogate marker for HIRI and severity was classified as minor(< 1000 IU/L), moderate(1000-5000 IU/L) or severe(> 5000 IU/L). The impact on time to extubation, intensive care length of stay, incidence of chronic renal failure and 90-d mortality were examined firstly for each of the two complications(AKI and HIRI) alone and then as a combined outcome. RESULTS Out of the 116 patients included in the study, 50% developed AKI, 24% required CVVHF and 70% sustainedmoderate or severe HIRI. Median peak AST levels were 1248 IU/L and 2059 IU/L in the No AKI and AKI groups respectively(P = 0.0003). Furthermore, peak serum AST was the only consistent predictor of AKI on multivariate analysis P = 0.02. AKI and HIRI were individually associated with a longer time to extubation, increased length of intensive care unit stay and reduced survival. However, the patients who sustained both AKI and moderate or severe HIRI had a longer median time to extubation(P < 0.001) and intensive care length of stay(P = 0.001) than those with either complication alone. Ninety-day survival in the group sustaining both AKI and moderate or severe HIRI was 89%, compared to 100% in the groups with either or neither complication(P = 0.049). CONCLUSION HIRI has an important role in the development of AKI post-OLT and has a negative impact on patient outcomes, especially when occurring alongside AKI. | Suehana Rahman Susan V Mallett Brian R Davidson | 2017 | World Journal of Hepatology2017，9，18： | 6 |
| 2 | Effects of T-2 mycotoxin on gastrointestinal tissues : a review of in vivo and in vitro models 显示文摘 | WORRELL N R MALLETT A K COOK W M | 1989 | Environ Toxicol1989，18，1： | 1 |
| 3 | Intellectual property rights and low carbon technology transfer: conflicting discourses of diffusion and development 显示文摘 | Ockwell D G Haum R Mallett A | 2010 | Global Environmental Change2010，20，4： | 1 |
| 4 | Voronoi cell finite elements 显示文摘 | Ghosh S Mallett R L | 1994 | Computers and Structures1994，50，1： | 1 |
| 5 | Intellectual property rights and low carbon technology transfer: Conflicting discourses of diffusion and development 显示文摘 | Ockwell D G Haum R Mallett A | 2010 | Global Environmental Change2010，20，4： | 1 |
| 6 | Theeffect of various dietary fibres on tissue concentration andchemical form of mercury after methylmercury exposure inmice显示文摘 | ROWLAND I R MALLETT A K FLYNN J | 1986 | Arch Toxicol1986，59，2： | 1 |
| 7 | Surface morphology evolution during electrodeposition of amorphous CoP films显示文摘 | da Silva R C Pasa A A Mallett J J | 2005 | Surface Science2005，，10： | 1 |
| 8 | Voronoi cell finite-elements显示文摘 | MALLETT R | 1994 | Comput Struct1994，50，1： | 1 |
| 9 | Voronoi cell finite elements 显示文摘 | Ghosh S Mallett R L | 1994 | Computers & Structures1994，50，1： | 1 |
| 10 | Voronoi cell finite elements显示文摘 | Ghosh S Mallett R L | 1994 | Computers & Structures1994，50，1： | 1 |
| 11 | Voronoi cell finite elements显示文摘 | Ghosh S Mallett R L | 1994 | Computers & Structures1994，50，1： | 1 |
| 12 | The importance of accurate pathological assessment of lymph node involvement in colorectal cancer显示文摘 | Schofield JB Mounter NA Mallett R | 2006 | Colorectal Dis2006，8，6： | 1 |
| 13 | Stray field imaging by magnetic field sweep显示文摘 | Mallett M J D Halse M R Strange J H | 1998 | J Magn Reson1998，132，1： | 1 |
| 14 | Voronoi cell finite elements显示文摘 | GHOSH S MALLETT R L | 1994 | Computers& Structures1994，50，1： | 1 |
| 15 | Evaluation of rheological properties of non-Newtonian fluids in internal mixers:an alternative method based on the power law model显示文摘 | Mallette J G Soberanis R R | | 0，，09： | 1 |
| 16 | Heavy drinking in college students:who is at risk and what is being done about it显示文摘 | Turrisi R Mallett KA Mastroleo NR | 2006 | J Gen Psychol2006，133，4： | 1 |
| 17 | A generalized assignment approach to optimal facility layout显示文摘 | Mallette A J Francis R L | 1972 | AIIE Transactions1972，4，2： | 1 |
| 18 | Finite element analysis of nonlinear structures显示文摘 | MALLETT R H MARCAL P V | 1968 | Journal of Structural Division ASCE1968，94，： | 1 |
| 19 | Car- bon black filled PET/PMMA blends:Electrical and morphologi- cal studies显示文摘 | Mallette J O Mdrquez A Manero O Castro-Rodriguez R | 2000 | Polymer Engineering & Science2000，40，10： | 1 |
| 20 | The use of rats associated with a human faecal flora as a model for studying the effects of diet on the human gut microfloral显示文摘 | Mallett A K Bearne C A Rowland I R | 1987 | Journal of Applied Bacteriology1987，63，： | 1 |
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