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| 1 | 铜绿假单胞菌对β-内酰胺类抗生素耐药性主决定因素的研究显示文摘对 β-内酰胺类抗生素耐药的铜绿假单胞菌临床分离株的耐药机理进行了研究 ,内容包括 β-内酰胺酶的表达、细胞外膜通透性、主动外排和青霉素结合蛋白的改变等 ,重点研究了 2株对头孢他啶耐药且其MIC相似的临床分离铜绿假单胞菌 P.a.18SH和 P.a.143811。在这 2株菌中没有发现主动外排现象引起的细菌对 β-内酰胺类抗生素耐药 ,其中 ,P.a.18SH对头孢他啶的耐药性可由其低的细胞外膜通透性和高活性Class C类 β-内酰胺酶的表达来解释。P.a.143811有相当高的外膜通透性 ,其产生的 β-内酰胺酶特点与 P.a.18SH相似 ,但表达水平及总活性比 P.a.18SH酶低 ,与敏感菌相似。通过进一步的研究发现 ,P.a.143811的耐药性可能由于其具有多个 PBP基因突变 ,导致多个 PBPs对 β-内酰胺抗生素的敏感性发生改变或过度表达 ,其中的几个低分子量 PBPs可能与 D,D-羧肽酶活性有关。这是第一次在耐药的铜绿假单胞菌临床分离菌中报道 PBPs的过度表达。提示铜绿假单胞菌对β-内酰胺类抗生素的耐药性具有多样性 ,在新药研制和临床使用抗菌药物时应注意这些耐药特点。 | 张风凯 Malcom G.P.Page 金少鸿 | 2000 | 中国抗生素杂志2000，25，5： | 46 |
| 2 | The role of radiotherapy in localised and locally advanced prostate cancer显示文摘For a patient suffering from non-metastatic prostate cancer,the individualized recommendation of radiotherapy has to be the fruit of a multidisciplinary approach in the context of a Tumor Board,to be explained carefully to the patient to obtain his informed consent.External beam radiotherapy is now delivered by intensity modulated radiotherapy,considered as the gold standard.From a radiotherapy perspective,low-risk localized prostate cancer is treated by image guided intensity modulated radiotherapy,or brachytherapy if patients meet the required eligibility criteria.Intermediate-risk patients may benefit from intensity modulated radiotherapy combined with 4e6 months of androgen deprivation therapy;intensity modulated radiotherapy alone or combined with brachytherapy can be offered to patients unsuitable for androgen deprivation therapy due to co-morbidities or unwilling to accept it to preserve their sexual health.High-risk prostate cancer,i.e.high-risk localized and locally advanced prostate cancer,requires intensity modulated radiotherapy with long-term(≥2 years)androgen deprivation therapy with luteinizing hormone releasing hormone agonists.Post-operative irradiation,either immediate or early deferred,is proposed to patients classified as pT3pN0,based on surgical margins,prostate-specific antigen values and quality of life.Whatever the techniques and their degree of sophistication,quality assurance plays a major role in the management of radiotherapy,requiring the involvement of physicians,physicists,dosimetrists,radiation technologists and computer scientists.The patients must be informed about the potential morbidity of radiotherapy and androgen deprivation therapy and followed regularly during and after treatment for tertiary prevention and evaluation.A close cooperation is needed with general practitioners and specialists to prevent and mitigate side effects and maintain quality of life. | Michel Bolla Ann Henry Malcom Mason Thomas Wiegel | 2019 | Asian Journal of Urology2019，6，2： | 5 |
| 3 | Smoking is associated with advanced coronary atherosclerosis in youth显示文摘 | Arthur W. Zieske C. Alex McMahan Henry C. McGill Satoki Homma Hidehiro Takei Gray T. Malcom Richard E. Tracy Jack P. Strong | 2004 | Atherosclerosis2004，，1： | 2 |
| 4 | Prevalence and extent of atherosclerosis in adolescents and young adults:implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study显示文摘 | Strong JP Malcom GT McMahan CA | 1999 | JAMA1999，281，8： | 1 |
| 5 | Elevated C - reactive protein values and at herosclerosis in sudden coronary death association with different pat hologies 显示文摘 | BURKE A P TRACY R P MALCOM G T | 2001 | Circulation2001，105，： | 1 |
| 6 | Increased androgen response to follicle -stimulating hormone administration in women with polycystic ovary syndrome显示文摘 | Wachs D S Coffler M S Malcom P J | 2008 | J Clin Endocrinol Metab2008，93，5： | 1 |
| 7 | The result of partial arthroscopic meniscectomy in patient over 40 years of age显示文摘 | Malcom JN | 1982 | J Bone Joint Surg(Br)1982，64，： | 1 |
| 8 | Dehydroepiand- rosterone alters Zucker rat soleus and cardiac muscle lipid profiles显示文摘 | Abadie JM Malcom GT Porter JR | 2001 | Exp Biol Med(Maywood)2001，226，8： | 1 |
| 9 | coronary risk factors and plaque morphology in men with coronary disease who died suddenly显示文摘 | Burke A P Farb A Malcom G T | | 0，，144： | 1 |
| 10 | Canassociations between free fatty acid levels and metabolic parameters determine insulin resistance development in obese Zueker rats 显示文摘 | Abadie J M Malcom GT Porter JR | 2001 | Life Sec2001，69，： | 1 |
| 11 | Prevalence and extent of athercsclerosis in adolescents and young adults, implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study显示文摘 | Strong JP Malcom GT McMahan CA | 1999 | JAMA1999，281，： | 1 |
| 12 | Ccoronary risk factors and plaque moephology in men coronary disease who died suddenly显示文摘 | Burke AP Farb A Malcom GT | 1997 | N Eng J Med1997，336，： | 1 |
| 13 | Coronary risk factors and plaque morphology in men with coronary disease who died suddenly显示文摘 | Farb A Malcom GT | 1997 | NEngl J Med1997，336，： | 1 |
| 14 | Real-life contexts for learning physics: meaning, issues and practice显示文摘 | Eizabeth W Malcom M | 1999 | Phys Educ1999，34，： | 1 |
| 15 | Canadian Cardiovascular Society Consensus Conference guidelines on heart failure--2008 update:best practices for the transition of care of heart failure patients,and the recognition,investigation and treatment of cardiomyopathies显示文摘 | Malcom J Arnold O Howlett JG | 2008 | Can J Cardiol2008，24，1： | 1 |
| 16 | Serum anti-mullerian hormone concentration are not altered by acute administration of follicle stimulating hormone in polycystic ovary syndrome and normal women显示文摘 | Wachs DS Coffler MS Malcom PJ | 2007 | J Clin Endocrinol Metab2007，92，5： | 1 |
| 17 | Coronary risk factors and plaque morphology in men with coronary disease who died suddenly显示文摘 | Burke AP Farb A Malcom GT | 1997 | N Engl J Med1997，336，18： | 1 |
| 18 | Elevated C-reactive protein values and atherosclerosis in sudden coronary death association with different pathologies显示文摘 | BURKE A P TRACY R P MALCOM G T | 2001 | Circulation2001，105，： | 1 |
| 19 | Coronary risk factors and plaque morphology in men with coronary disease who died suddenly显示文摘 | Burke A P Farb A Malcom G T | 1997 | N Engl J Med1997，336，： | 1 |
| 20 | Early inflammatory-immunological lesions inJuvenile atherosclerosis from the Pathobio logical Determinants of Atherosclerosis in Youth (PDAY)-study显示文摘 | Millonig G Malcom GT Wickg | 2002 | Atherosclerosis2002，160，2： | 1 |
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