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| 1 | Emerging role of obeticholic acid in the management of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is the commonest chronic liver disease and its prevalence is increasing driven by the pandemic of obesity and type 2 diabetes mellitus. NAFLD can progress to cirrhosis and is associated with increased risk for cardiovascular disease and hepatocellular cancer. Diet and exercise are limited by suboptimal long-term adherence in patients with NAFLD. On the other hand, current pharmacological treatment of NAFLD has limited efficacy and unfavorable safety profile. In this context, obeticholic acid(OCA), a selective agonist of the farnesoid X receptors, might represent a useful option in these patients. Preclinical studies suggest that OCA improves hepatic steatosis, inflammation and fibrosis. A proof-of-concept study and the randomized, placebo-controlled Farnesoid X Receptor Ligand Obeticholic Acid in non-alcoholic steatohepatitis Treatment(FLINT) trial also showed improvements in liver histology in patients with NAFLD who received OCA. Weight loss and reduction in blood pressure were also observed. However, the effects of OCA on insulin resistance are conflicting and the lipid profile is adversely affected by this agent. In addition, pruritus is frequently observed during treatment with OCA and might lead to treatment discontinuation. However, given the limitations of existing treatments for NAFLD, OCA might represent a useful therapeutic option in selected patients with NAFLD. | Evangelia Makri Evangelos Cholongitas Konstantinos Tziomalos | 2016 | World Journal of Gastroenterology2016，22，41： | 8 |
| 2 | Taking central nervous system regenerative therapies to the clinic: curing rodents versus nonhuman primates versus humans显示文摘The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of effective and safe therapeutic options for such patients.Despite the high prevalence of stroke and spinal cord injury in the general population,these conditions remain incurable and place a heavy burden on patients’families and on society more broadly.Neuroregeneration and neural engineering are diverse biomedical fields that attempt reparative treatments,utilizing stem cells-based strategies,biologically active molecules,nanotechnology,exosomes and highly tunable biodegradable systems(e.g.,certain hydrogels).Although there are studies demonstrating promising preclinical results,safe clinical translation has not yet been accomplished.A key gap in clinical translation is the absence of an ideal animal or ex vivo model that can perfectly simulate the human microenvironment,and also correspond to all the complex pathophysiological and neuroanatomical factors that affect functional outcomes in humans after central nervous system injury.Such an ideal model does not currently exist,but it seems that the nonhuman primate model is uniquely qualified for this role,given its close resemblance to humans.This review considers some regenerative therapies for central nervous system repair that hold promise for future clinical translation.In addition,it attempts to uncover some of the main reasons why clinical translation might fail without the implementation of nonhuman primate models in the research pipeline. | Magdalini Tsintou Kyriakos Dalamagkas Nikos Makris | 2020 | Neural Regeneration Research2020，15，3： | 7 |
| 3 | Personalized real-time pricing for efficient and fair demandresponse in energy cooperatives and highly competitive flexibility markets显示文摘This paper contributes to the well-known challenge of active user participation in demand side management(DSM).In DSM, there is a need for modern pricing mechanisms that will be able to effectively incentivize selfishly behaving users in modifying their energy consumption pattern towards system-level goals like energy efficiency.Three generally desired properties of DSM algorithms are: user satisfaction, energy cost minimization and fairness.In this paper, a personalized real-time pricing(P-RTP) mechanism design framework is proposed that fairly allocates the energy cost reduction only to the users that provoke it.Thus, the proposed mechanism achieves significant reduction of the energy cost without sacrificing at all the welfare(user satisfaction)of electricity consumers.The business model that the proposed mechanism envisages is highly competitive flexibility market environments as well as energy cooperatives. | Georgios TSAOUSOGLOU Nikolaos EFTHYMIOPOULOS Prodrommos MAKRIS Emmanouel VARVARIGOS | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 4 |
| 4 | Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis显示文摘大动脉的狭窄(作为) 是瓣膜的心疾病在的最普通的类型老。外科的大动脉的阀门代替(SAVR ) 是为对待的标准实践严重、作为征兆,却最近新治疗选择出现了。Transcatheter 大动脉的阀门代替(TAVR ) 现在是在在高外科的风险的病人的一种确定的治疗选择。在这评论,我们集中于最近的开发并且以功效和安全在特定的人口比较二个治疗方法(例如在有优先的胸的外科的历史的病人,采用的麻醉打字,存取使用的地点或为永久踱步需要) 。comorbidities (肺的高血压,动脉的高血压和肥胖悖论) 的影响,在象应得进一步的调查的问题一样的 transcatheter 阀门技术的 TAVR 对 SAVR 和进展的划算进一步被讨论。而且,在不同风险范畴(极其高、高、中间、低的风险) 的病人的 TAVR 的结果和复杂并发症被分析。我们强烈相信在下列年期间, TAVR 可以在病人的一个更宽广的组作为选择的治疗演变与与中间、高风险的特征作为并且在那些以外征兆。 | Tsigkas Grigorios Despotopoulos Stefanos Makris Athanasios Koniari Ioanna Armylagos Stylianos Davlouros Periklis Hahalis George | 2018 | Journal of Geriatric Cardiology2018，15，1： | 2 |
| 5 | The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke:a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches显示文摘Neural tissue engineering,nanotechnology and neuroregeneration are diverse biomedical disciplines that have been working together in recent decades to solve the complex problems linked to central nervous system(CNS)repair.It is known that the CNS demonstrates a very limited regenerative capacity because of a microenvironment that impedes effective regenerative processes,making development of CNS therapeutics challenging.Given the high prevalence of CNS conditions such as stroke that damage the brain and place a severe burden on afflicted individuals and on society,it is of utmost significance to explore the optimum methodologies for finding treatments that could be applied to humans for restoration of function to pre-injury levels.Extracellular vesicles(EVs),also known as exosomes,when derived from mesenchymal stem cells,are one of the most promising approaches that have been attempted thus far,as EVs deliver factors that stimulate recovery by acting at the nanoscale level on intercellular communication while avoiding the risks linked to stem cell transplantation.At the same time,advances in tissue engineering and regenerative medicine have offered the potential of using hydrogels as bio-scaffolds in order to provide the stroma required for neural repair to occur,as well as the release of biomolecules facilitating or inducing the reparative processes.This review introduces a novel experimental hypothesis regarding the benefits that could be offered if EVs were to be combined with biocompatible injectable hydrogels.The rationale behind this hypothesis is presented,analyzing how a hydrogel might prolong the retention of EVs and maximize the localized benefit to the brain.This sustained delivery of EVs would be coupled with essential guidance cues and structural support from the hydrogel until neural tissue remodeling and regeneration occur.Finally,the importance of including nonhuman primate models in the clinical translation pipeline,as well as the added benefit of multi-modal neuroimaging analysis to establish non-invasive,in vivo,quantifiable imagingbased biomarkers for CNS repair are discussed,aiming for more effective and safe clinical translation of such regenerative therapies to humans. | Magdalini Tsintou Kyriakos Dalamagkas Tara LMoore Yogesh Rathi Marek Kubicki Douglas LRosene Nikos Makris | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 6 | Overexpression of a specific soybean Gm GSTU4 isoenzyme improves diphenyl ether and chloroacetanilide herbicide tolerance of transgenic tobacco plants显示文摘 | Kostantinos Benekos Christos Kissoudis Irini Nianiou-Obeidat Nikolaos Labrou Panagiotis Madesis Mary Kalamaki Antonis Makris Athanasios Tsaftaris | 2010 | Journal of Biotechnology2010，，1： | 2 |
| 7 | Morphometry of in vivo human white matter association pathways with diffusion weighted MRI显示文摘 | Makris N Worth A J Sorensen G | 1997 | Annals of Neurology1997，42，6： | 1 |
| 8 | Antiendothelial cell antibody levels in patients with masked hypertension 显示文摘 | Papadopoulos DP Makris TK Papazachou U | 2008 | Int J Cardiol2008，，： | 1 |
| 9 | WAF1/p21 regulates proliferation, but does not mediate p53 dependent apoptosis in urothelial carcinoma cell lines显示文摘 | Makri D Schulz WA Grimm M | 1998 | Int J Oncol1998，12，3： | 1 |
| 10 | Dynamic pile-soil-pile interaction (Part Ⅰ):analysis of axial vibration显示文摘 | Gazetas G Makris N | 1991 | Earthquake Engineering and Structure Dynamics1991，20，： | 1 |
| 11 | Viscous heating of fluid dampers II: large-amplitude motions显示文摘 | MAKRIS N ROUSSOS Y WHITTAKER A | 1998 | Journal of Engineering Mechanics1998，124，12： | 1 |
| 12 | Early changes in functional dynamic magnetic resonance imaging predict for pathologic response to neoadjuvant chemotherapy in primary breast Cancer 显示文摘 | Ah-See ML Makris A Taylor NJ | 2008 | Clin Cancer Res2008，14，： | 1 |
| 13 | Kinetics of browning onset in white wines:Influence of principal redox-active poly phenols and impact on the reducing capacity 显示文摘 | Sioumis N Kallithraka S Makris D P | 2006 | Food Chem- istry2006，94，1： | 1 |
| 14 | Simulation analysis for midterm yasat planning in container terminal显示文摘 | Sgouridis S P Makris D Angelides D C | 2003 | Journal dWaterway Port Coastal and O-cean Engineering2003，129，4： | 1 |
| 15 | A benign Mullerian cyst of the uterus显示文摘 | Prasannan-Nair C Makris A Abdel-Rahman H | 2007 | J Obstet Gynaecol2007，27，5： | 1 |
| 16 | Increased incidence of anti-LKM autoantibodies in a consecutive cohort of hepatitis C patients from central Greece显示文摘 | Georgios N. Dalekos Eirini Makri Stephanie Loges Petra Obermayer-Straub Kalliopi Zachou Thomas Tsikrikas Elenore Schmidt Georgia Papadamou Michael P. Manns | 2002 | European Journal of Gastroenterology & Hepatology2002，，1： | 1 |
| 17 | Urinary neutrophil geltinase-associated (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients显示文摘 | Makris K Markou N | 2009 | Clinical Chemistry2009，47，1： | 1 |
| 18 | Component Testing, Characterization of Buckling-restrained Braces显示文摘 | Black C Makris N Aiken Seismic Evaluation and L | 2004 | Journal of Structural Engineering2004，130，6： | 1 |
| 19 | Observation of Discrete Quadratic Surface Solitons 显示文摘 | SIVILOGLOU G A MAKRIS K G IWANOW R et a l | 2006 | Opt Express2006，14，： | 1 |
| 20 | Hyperhomocysteinemia and thrombosis 显示文摘 | Makris M | 2000 | Clin Lab Haematol2000，22，3： | 1 |
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