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| 1 | Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia显示文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival. | Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud | 2012 | World Journal of Gastroenterology2012，18，5： | 7 |
| 2 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 3 | Imaging pancreatobiliary ductal system with optical coherence tomography: A review显示文摘An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography(OCT) is a noninvasive, high-resolution(1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of thepancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions. | Mohammad S Mahmud Gray R May Mohammad M Kamal Ahmed S Khwaja Carry Sun Alex Vitkin Victor XD Yang | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 2 |
| 4 | Bibliography on the application of probability methods in power system reliability evaluation 1996-1999显示文摘 | Billinton R Mahmud F F Bertling L | 2001 | IEEE Trans on Power Systems2001，16，4： | 1 |
| 5 | HLA polymorphisms and cervical human papillomavirus infection in a cohort of Montreal University Students显示文摘 | Mahmud SM Robinson K Richandson R | 2007 | J Infect Dis2007，196，1： | 1 |
| 6 | Aerodynamics of low-blowing-ratio fuselage injection into a supersonic freestream显示文摘 | Mahmud Z Bowersox R D W | 2005 | Journal of Spacecraft and Rockets2005，42，1： | 1 |
| 7 | Brinkman Forchheimer mod -eling for porous media thermoacoustie system 显示文摘 | Tasnim S H Mahmud S Fraser R A | 2011 | International Journal of Heat and Mass Transfer2011，54，1718： | 1 |
| 8 | Robust partial feedback linearizing stabilization scheme for three-phase grid-connected photovoltaic systems显示文摘 | Mahmud M A Pota H R Hossain M J | 2014 | IEEE Journal of Photovoltaics2014，4，1： | 1 |
| 9 | Non-steroid- al anti-inflammatory drug use and prostate cancer in a high- risk population 显示文摘 | MAHMUD S M TANGUAY S BEGIN L R | 2006 | Eur J Cancer Prey2006，15，2： | 1 |
| 10 | Assessment of potential indigenous plant species for the phytoremediation of arsenic-contaminated areas of Bangladesh 显示文摘 | Mahmud R Inoue N Kasajima S Y | 2008 | Inter J Phytoremediation2008，10，2： | 1 |
| 11 | Assessment of potential indigenous plant species for the Phytoremediation of Arsenic-contaminated areas of Bangladesh显示文摘 | Mahmud R Inoue N Kasajima SY | 2008 | International Journal of Phytoremediation2008，10，2： | 1 |
| 12 | Full-order nonlinear observer-based excitation controller design for interconnected power systems via exact linearization approach显示文摘 | Mahmud M Pota H R Hossain M J | 2012 | International Journal of Electrical Power & Energy Systems2012，41，1： | 1 |
| 13 | Investigation of the impacts of large-scale wind power penetration on the angle and voltage stability of power systems 显示文摘 | Hossain M J Pota H R Mahmud M A | 2012 | Systems Journal IEEE2012，6，1： | 1 |
| 14 | Nonlinear current control scheme for a single-phase grid-connected photovoltaic system显示文摘 | M A Mahmud H R Pota M J Hossain | 2014 | IEEE Transactions on Sustainable Energy2014，5，1： | 1 |
| 15 | Randomized controlled trial of day care versus hospital care of severe pneumonia in Bangladesh 显示文摘 | Ashraf H Mahmud R Alam NH | 2010 | Pediatrics2010，126，4： | 1 |
| 16 | Anemia characteristics after renal transplantation显示文摘 | Mahmud SN Aziz R Ahmed E | 2012 | Transplant Proc2012，34，6： | 1 |
| 17 | Stabilization of residual soil with rice husk ash and cement显示文摘 | Basha E A Hashim R Mahmud H B | 2005 | Construction and Building Materials2005，19，： | 1 |
| 18 | Potential impact of magnetic resonance cholangiopancreatography on endoscopic retrograde cholangiopancreatography workload and complica- tion rate in patients referred because of abdominal pain 显示文摘 | Farrell R J Noonan N Mahmud N | 2001 | Endoscopy2001，33，8： | 1 |
| 19 | Analysis of entropy generation inside concentric cylindrical annuli with relative rotation显示文摘 | Mahmud S Fraser R A | 2003 | Int J Thermal Sciences2003，42，5： | 1 |
| 20 | Computer games development and appreciative learning approach in enhancing students' creative perception 显示文摘 | Eow Y L Baki R Mahmud R | 2010 | Computers & Education2010，54，1： | 1 |
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