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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Emergency cholecystectomy vs percutaneous cholecystostomy plus delayed cholecystectomy for patients with acute cholecystitis显示文摘BACKGROUND: In low-risk patients with acute cholecystitis who did not respond to nonoperative treatment, we prospectively compared treatment with emergency laparoscopic cholecystectomy or percutaneous transhepatic cholecystostomy followed by delayed cholecystectomy.METHODS: In 91 patients(American Society of Anesthesiologists class I or II) who had symptoms of acute cholecystitis ≥72 hours at hospital admission and who did not respond to nonoperative treatment(48 hours), 48 patients were treated with emergency laparoscopic cholecystectomy and 43 patients were treated with delayed cholecystectomy at ≥4 weeks after insertion of a percutaneous transhepatic cholecystostomy catheter. After initial treatment, the patients were followed up for 23 months on average(range 7-29).RESULT: Compared with the patients who had emergency laparoscopic cholecystectomy, the patients who were treated with percutaneous transhepatic cholecystostomy and delayed cholecystectomy had a lower frequency of conversion to open surgery [19(40%) vs 8(19%); P=0.029], a frequency of intraoperative bleeding ≥100 mL [16(33%) vs 4(9%); P=0.006],a mean postoperative hospital stay(5.3±3.3 vs 3.0±2.4 days;P=0.001), and a frequency of complications [17(35%) vs 4(9%);P=0.003].CONCLUSION: In patients with acute cholecystitis who presented to the hospital ≥72 hours after symptom onset and did not respond to nonoperative treatment for 48 hours, percutaneous transhepatic cholecystostomy with delayed laparoscopic cholecystectomy produced better outcomes and fewer complications than emergency laparoscopic cholecystectomy. | Feza Y Karakayali Aydincan Akdur Mahir Kirnap Ali Harman Yahya Ekici G?han Moray | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 20 |
| 3 | Internal biliary fistula due to cholelithiasis:A single-centre experience显示文摘AIM: To discuss about the perioperative problems encountered in patients with internal biliary fistula (IBF) caused by cholelithiasis. METHODS: In our hospital, 4 130 cholecystectomies were carried out for symptomatic cholelithiasis from January 2000 to March 2004 and only 12 patients were diagnosed with IBF. The perioperative data of these 12 IBF patients were analyzed retrospectively. RESULTS: The incidence of IBF due to cholelithiasis was nearly 0.3%. The mean age was 57 years. Most of the patients presented with non-specific complaints. Only two patients were considered to have IBF when gallstone ileus was observed during the investigations. Nine patients underwent emergency laparotomy with a pre-operative diagnosis of acute abdomen. In the remaining three patients, elective laparoscopic cholecystectomy was converted to open surgery after identification of IBF. Ten patients had cholecystoduodenal fistula and two patients had cholecystocholedochal fistula. The mean hospital stay was 13 d. Two wound infections, three bile leakages and three mortalities were observed. CONCLUSION: Cholecystectomy has to be performed in early stage in the patients who were diagnosed as cholelithiasis to prevent the complications like IBF which is seen rarely. Suspicion of IBF should be kept in mind, especially in the case of difficult dissection during cholecystectomy and attention should be paid in order to prevent iatrogenic injuries. | Arife Polat Duzgun Mehmet Mahir Ozmen Mehmet Vasfi Ozer Faruk Coskun | 2007 | World Journal of Gastroenterology2007，13，34： | 15 |
| 4 | Emergency admissions due to swallowed foreign bodies in adults显示文摘AIM:To study a retrospective analysis of patients who presented to the emergency departments(ED)with complaints related to foreign body ingestions.METHODS:Patients older than 16 years of age who presented to the ED between January 1stand December 31stof 2010 with complaints related to swallowed foreign bodies were identified from electronic health records and patient charts.RESULTS:A total of 100 patients presented with a complaint of foreign body ingestion during the study period.Overall,an X-ray was performed on 75 patients,and a fiberoptic evaluation was performed on45 patients.A foreign body was detected in 46(46%)patients.The diagnostic yield of the X-ray was 27(36%)out of 75 patients,while the diagnostic yield of the fiberoptic evaluations was 21(47%)out of 45 patients.The detected foreign bodies were mostly located in the esophagus(17 out of 46 foreign bodies detected).When the types of ingested foreign bodies were evaluated,52(52%)patients reported ingesting food,and19(19%)patients reported swallowing pins.An X-ray was performed on 33 patients with accidental food ingestions but yielded a positive result in only two cases.In 12 out of 21 patients with accidental food ingestion who underwent fiberoptic evaluation,the foreign material was detected and removed.CONCLUSION:Plain radiography is helpful in the localization of radiopaque swollen foreign bodies,while fiberoptic methods are useful as both diagnostic and therapeutic tools,regardless of radiopacity. | Bülent Erbil Mehmet Ali Karaca Mehmet Ali Aslaner Zaur Ibrahimov Mehmet Mahir Kunt Erhan Akpinar Mehmet Mahir zmen | 2013 | World Journal of Gastroenterology2013，19，38： | 11 |
| 5 | Gallbladder cancer:Historical treatment and new management options显示文摘Gallbladder cancer is a rare,aggressive malignancy that has a poor overall prognosis.Effective treatment consists of early detection and surgical treatment.With the wide spread treatment of gallbladder disease with minimally invasive techniques,the rate of incidental gallbladder cancer has seen an equitable rise along with stage migration towards earlier disease.Although the treatment remains mostly surgical,newer modalities such as regional therapy as well as directed therapy based on molecular medicine has led to improved outcomes in patients with advanced disease.We aim to summarize the management of gallbladder cancer along with the newer developments in this formidable disease process. | Kenji Okumura Shekhar Gogna Mahir Gachabayov Daniel Moritz Felsenreich Matthew McGuirk AramRojas Luis Quintero Ramanathan Seshadri Katie Gu Xiang Da Dong | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 5 |
| 6 | The impact of extracellular and intracellular Ca2+ on ethanol-induced smooth muscle contraction显示文摘 | Naciye YAKTUBAY DONDA Mahir KAPLAN erya KAYA Ergin singIrIK | 2009 | Acta Pharmacologica Sinica2009，30，10： | 5 |
| 7 | Predictors of poor outcome in gastrointestinal bleeding in emergency department显示文摘AIM: To determine the prognostic risk factors of gastrointestinal bleeding in emergency department cases.METHODS: The trial was a retrospective single-center study involving 600 patients over 18-years-old and carried out with approval by the Institutional Ethics Committee. Patient data included demographic characteristics, symptoms at admission, past medical history, vital signs, laboratory results, endoscopy and colonoscopy results, length of hospital stay, need of intensive care unit(ICU) admission, and mortality. Mortality rate was the principal endpoint of the study, while duration of hospital stay, required interventional treatment, and admission to the ICU were secondary endpoints.RESULTS: The mean age of patients was 61.92-yearsold. Among the 600 total patients, 363(60.5%) underwent upper gastrointestinal endoscopy and the most frequent diagnoses were duodenal ulcer(19.2%) and gastric ulcer(12.8%). One-hundred-and-fifteen(19.2%) patients required endoscopic treatment, 20(3.3%) required surgical treatment, and 5(0.8%) required angiographic embolization. The mean length of hospital stay was 5.21 ± 5.85 d. The mortality rate was 6.3%. The ICU admission rate was 5.3%. Patients with syncope, higher blood glucose levels, and coronary artery disease had significantly higher ICU admission rates(P = 0.029, P = 0.043, and P = 0.002, respectively). Patients with low thrombocyte levels, high creatinine, high international normalized ratio, and high serum transaminase levels had significantly longer hospital stay(P = 0.02, P = 0.001, P = 0.019, and P = 0.005, respectively). Patients who died had significantly higher serum blood urea nitrogen and creatinine levels(P = 0.016 and P = 0.038), and significantly lower mean blood pressure and oxygen saturation(P = 0.004 and P = 0.049). Malignancy and low Glasgow coma scale(GCS) were independent predictive factors of mortality.CONCLUSION: Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hypotension on admission, low GCS, and impaired kidney function. | Ender Kaya Mehmet Ali Karaca Deniz Aldemir M Mahir Ozmen | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 8 | Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Has the Time Come for Cardiologists to Be Hepatologists?显示文摘 | Mohamed H. Ahmed Salma Barakat Ahmed O. Almobarak Mahir A. Hamad | 2012 | Journal of Obesity2012，，： | 3 |
| 9 | 前房注射0.1%莫西沙星联合结膜下注射曲安奈德预防超声乳化术后感染(英文)显示文摘目的:评估前房注射0.1%莫西沙星联合结膜下注射4 mg曲安奈德预防白内障超声乳化术后感染和炎症的疗效,并与局部滴药组比较。方法:共纳入1000例,平均年龄38~70岁,全部行超声乳化术的患者分为两组,两组在年龄、术前眼压(IOP)和中心黄斑厚度(CMT)方面无显著差异,分别为P=0.6,P=0.9和P=0.8。对照组患者500例,术后1mo每日4次局部应用0.5%盐酸莫西沙星和0.1%地塞米松滴眼液。研究组在手术结束时,前房注入0.1%莫西沙星0. 4 m L联合4 mg曲安奈德结膜下注射。随访时间为术后1d、1wk、1mo和3mo。检查4次前房反应,测量3次眼压,最后一次测量CMT。结果:该临床试验研究中两组人群分别应用不同的预防方法,两组无眼内炎病例发生。通过两样本t检验,术后1d,研究组前房细胞显著低于对照组,而术后1wk、1mo和3mo两组间无统计学差异。在第3mo随访时,两组间眼压和中心黄斑厚度无明显差异。对照组炎症发生率为9.6%,研究组为4%。对照组在1mo时眼压升高≥10 mmHg患者占2. 4%,显著高于研究(0.8%)。结论:白内障术后联合应用前房内莫西沙星和结膜下曲安奈德可有效预防感染和炎症,并且大多数(480例)患者不需其它任何外用药物,这为患者节省了成本,并帮助降低无法实施局部用药的病人并发症的几率与依从性差的患者术后不良药物反应。 | Suzan Amana Rattan Najah Kadhum Mohammad Mahir Kadhim Mutashar | 2018 | 国际眼科杂志2018，18，10： | 3 |
| 10 | The Interface Stress Field in the Elastic System Consisting of the Hollow Cylinder and Surrounding Elastic Medium Under 3D Non-Axisymmetric Forced Vibration显示文摘The paper develops and employs analytical-numerical solution method for the study of the time-harmonic dynamic stress field in the system consisting of the hollow cylinder and surrounding elastic medium under the non-axisymmetric forced vibration of this system.It is assumed that in the interior of the hollow cylinder the point-located with respect to the cylinder axis,non-axisymmetric with respect to the circumferential direction and uniformly distributed time-harmonic forces act.Corresponding boundary value problem is solved by employing of the exponential Fourier transformation with respect to the axial coordinate and by employing of the Fourier series expansion of these transformations.Numerical results on the frequency response of the interface normal stresses are presented and discussed. | Surkay D.Akbarov Mahir A.Mehdiyev | 2018 | Computers, Materials & Continua2018，，1： | 2 |
| 11 | Uptake of trivalent chromium ions from aqueous solutions using kaolinite 显示文摘 | Pinar Turan Mehmet Dogan Mahir Alkan | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 12 | Staging laparoscopy for gastric cancer, surgical laparoscopy显示文摘 | Ozmen M Mahir MD MS | 2003 | Endoscopy & Percu taneous Techniques2003，13，4： | 1 |
| 13 | Spectrophotometric determination of molybdenum with Alizarin Red S in the presence of poly (sulfonylpiperidinylmethylenehydroxide)显示文摘 | Mahir Alkan a Myroslava Kharun Fedor Chmilenko | 2003 | Talanta2003，59，3： | 1 |
| 14 | TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transcriporters CDR1 and CDR2 显示文摘 | Alix T Coste Mahir Karababa Francoise Ischer | 2004 | Eukaryotic Ce112004，，： | 1 |
| 15 | Global existence and nonllnear stability for the relativistic Vlasov -Poisson system in the gravitational case显示文摘 | Mahir Hadzic | 2007 | Indiana Univ Math J2007，56，： | 1 |
| 16 | A Simple Finite Element to Consider the Non-linear Influence of the Ballast on Vibrations of Railway Bridges 显示文摘 | BATTINI J M MAHIR U K | 2011 | Engineering Structures2011，33，9： | 1 |
| 17 | Removal of methyl violet from aqueous solu-tion by perlite显示文摘 | MEHMET D MAHIR A | 2003 | J Colloid and Interface Sci2003，267，： | 1 |
| 18 | Fate of the patient with chronic leg ischaemia:a review article显示文摘 | Dormandy J Mahir M Ascady G | 1989 | J Cardiovasc Surg (Torino)1989，30，1： | 1 |
| 19 | Numerical Investigation of Convective Heat Transfer in Unsteady Flow Past Two Cylinders in Tandem Arrangements 显示文摘 | Mahir N Altac Z | 2008 | Int J Heat Fluid Flows2008，29，5： | 1 |
| 20 | Spectrophotometric determination of molybdenum with Alizarin Red S in the presence of poly(sulfonylpiperidinylmethylene hydroxide) 显示文摘 | Mahir Alkan Myroslava Kharun Fedor Chmilenko | 2003 | Talanta2003，58，： | 1 |
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