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| 1 | Treatment of peri-anal fistula in Crohn's disease显示文摘Anal fistulas are a common manifestation of Crohn's disease(CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently em-ployed. However, at the moment, none of these tech-niques appear superior to the others in terms of healing rate. Surgery is always indicated to treat symptomatic, simple, low intersphincteric fistulas refractory to medi-cal therapy and those causing disabling symptoms. Ut-most attention should be paid to correcting the balance between eradication of the fistula and the preservationof fecal continence. | Giuseppe S Sica Sara Di Carlo Giorgia Tema Fabrizio Montagnese Giovanna Del Vecchio Blanco Valeria Fiaschetti Giulia Maggi Livia Biancone | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 2 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 3 | Diabetes and osteoporosis 显示文摘 | Sailer A Maggi S Romanato G | 2008 | Aging Clin Exp Res2008，20，4： | 1 |
| 4 | Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions显示文摘 | CATALIOTO R M MAGGI C A GIULIANI S | 2011 | Curr Med Chem2011，18，3： | 1 |
| 5 | Properties and origin of human Th17 cells显示文摘 | Romagnani S Maggi E Liotta F | 2009 | Mol Immunol2009，47，1： | 1 |
| 6 | Adjunctive diagnostic value of ultrasonography evaluation in patients with suspected ductal breast disease 显示文摘 | Ballesio L Maggi C Savelli S | 2007 | Radiol Med (Torino)2007，112，3： | 1 |
| 7 | High efficiency double heterojunction polymer photovoltaic cells using highly ordered TiO2 nanotube arrays 显示文摘 | Gopal K M Karthik S Maggie P | 2007 | Appl Phys Lett2007，91，15： | 1 |
| 8 | Variability of anthropogenic and natural compounds in high altitude-high accumulation alpine glaciers 显示文摘 | Maggi V Villa S Finizio A | 2006 | Hydrobiologia2006，562，： | 1 |
| 9 | Diabetes and osteoporosis显示文摘 | Saller A Maggi S Romanato G | 2008 | Aging Clin Exp Res2008，20，4： | 1 |
| 10 | Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions显示文摘 | Catalioto RM Maggi CA Giuliani S | 2011 | Curr Med Chem2011，18，3： | 1 |
| 11 | Role of breast Magnetic Resonance Imaging (MRI) in patients with unilateral nipple di charge : preliminary study显示文摘 | Ballesio L Maggi C Savelli S | 2008 | Radiol Med( Torino)2008，113，2： | 1 |
| 12 | Optimal management of peptic ulcer disease in the elderly显示文摘 | Pilotto A Franceschi M Maggi S | 2010 | Drugs Aging2010，27，7： | 1 |
| 13 | Depressive symp- toms and development of coronary heart disease events : the Italian longitudinal study on aging 显示文摘 | Marzari C Maggi S Manzato E | 2005 | J Gerontol A Biol Sci Med2005，60，1： | 1 |
| 14 | Multimodal management of stages III–IVa malignant thymoma显示文摘 | S Bretti A Berruti C Loddo P Sperone C Casadio M Tessa F Ardissone G Gorzegno M Sacco E Manzin P Borasio G.L Sannazzari G Maggi L Dogliotti | 2003 | Lung Cancer2003，，1： | 1 |
| 15 | Celsior solution and clinical liver transplantation显示文摘 | Maggi U Caccamo L Gatti S | 2000 | Transplant Proc2000，32，1： | 1 |
| 16 | Use of sildenafil in the chronic uremic patient显示文摘 | Punzo G Maggi S Ponzio R | 2001 | Minerva Urol Nefrol2001，53，1： | 1 |
| 17 | Properties and origin of human Th17 cells显示文摘 | Romagnani S Maggi E Liotta F | 2009 | Mol Immunol2009，47，1： | 1 |
| 18 | Incidence of hip fractures in the elderly:a cross-national study显示文摘 | Maggi S Litvak J | 1991 | Osteoporosis Int1991，1，： | 1 |
| 19 | Detecting intrusions through system call sequence and argument analysis 显示文摘 | Maggi F Matteucci M Zanero S | 2010 | IEEE Transactions on Dependable and Secure Computing2010，7，4： | 1 |
| 20 | Genetic engineering of Streptococcus gordonii for the simultaneous display of two heterologous proteins at the bacterial surface 显示文摘 | Maggi T Spinosa M Ricci S | 2002 | FEMS Microbiol Lett2002，210，1： | 1 |
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