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| 1 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | EGF receptor in human Chang liver and hepatoma HepG2 cells显示文摘 | Yang EB Wang DF Mack P | 1996 | Biolchem Mol Biol Int1996，38，4： | 1 |
| 4 | Pregnancy associated plasma protein A and proform eosinophilie major basic protein in the detection of different types of eomnacy artery disease显示文摘 | Hajek P Mack M Hladikova M | 2008 | Physiol Res2008，57，： | 1 |
| 5 | Formation and characterisation of a chromate conversion coating on AA6060 aluminium显示文摘 | O LUNDER J C WALMSLEY P MACK | 2005 | Corrosion Science2005，47，： | 1 |
| 6 | Apoptosis induced by hyperthermia in Dunn osteosarcoma cell line in vitro显示文摘 | Rong Y Mack P | 2000 | Int J Hyperthermia2000，16，1： | 1 |
| 7 | Antagonistic control of oxidative stress induced cell death in Arabidopsis by two related,plant-specific zinc finger proteins显示文摘 | EPPLE P MACK A A | | 0，，： | 1 |
| 8 | PKA-dependent phesphorylation of serum response factor inhibits smooth muscle-specific gene expres- sion显示文摘 | Blaker A L Taylor J M Mack C P | 2012 | Arterioscler Thromb Vasc Biol2012，29，12： | 1 |
| 9 | A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity显示文摘 | MACK M RIETHMULLER G KUFER P | 1995 | Proc Nat Acad Sci U S A1995，92，15： | 1 |
| 10 | Apoptosis induced by hyperthermia in Dunn osteosarcoma cell line in vitro 显示文摘 | Rong Y Mack P | 2000 | Int J Hyperther- mia2000，16，1： | 1 |
| 11 | Common and wel -documented HLA al eles:report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics显示文摘 | Cano P Klitz W Mack SJ | | 0，，05： | 1 |
| 12 | Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides显示文摘 | Potempska A Mack K Mehta P | 1999 | Amyloid1999，6，1： | 1 |
| 13 | Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study 显示文摘 | MACKNESS B DURRINGTON P MCELDUFF P | 2003 | Circulation2003，107，22： | 1 |
| 14 | Mercury methylation from unexPected sources:Molybdate-inhibited freshwater sediments and an iron-reducing bacterium显示文摘 | Fleming E J Mack E E Green P G | 2006 | Applied and Environmental Microbiology2006，72，1： | 1 |
| 15 | Signaling mechanisms that regulate smooth muscle cell differentiation显示文摘 | Mack C P | 2011 | Arterioscler Thromb Vasc Biol2011，31，7： | 1 |
| 16 | Characterization of distribution power quality events with Fourier and wavelet transforms 显示文摘 | SURYA S MACK G W EDWARD P J | 2000 | IEEE Transactions on Power Delivery2000，15，1： | 1 |
| 17 | On measuring the radar cross sections of ducks and chickens显示文摘 | Blacksmith P Jr Mack R B | 1965 | Proceedings of the IEEE1965，53，8： | 1 |
| 18 | H-IV-1 Tat Peptide Binding to RAR RNA by Electrospray Ionization Mass Spectrometry显示文摘 | Sannes-Lowery KA Hu P Mack DP | 1997 | Anal Chem1997，69，24： | 1 |
| 19 | Kernel Estimation in Transect Sampling Without the Shoulder Condition显示文摘 | Y P Mack P X Quang S Zhang | 1999 | Communications in Statistics Theory and Methods1999，28，10： | 1 |
| 20 | Paraoxonase:biochemistry,genetics and relationship to plasma lipoproteins显示文摘 | MACKNESS M I MACKNESS B DURRINGTON P N | 1996 | Curr Opin Lipidol1996，7，2： | 1 |
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