|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis显示文摘AIM:To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.METHODS:This was an analytical cross-sectional study to validate the diagnostic test for hepatic cirrhosis and was performed between February 2010 and December 2011.Patients with a diagnosis of hepatic cirrhosis were included and stratified using their ChildPugh score.Biochemical parameters were evaluated,and ultrasound was used to measure the longest diameter of the spleen.The platelet count/spleen diameter ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices.Upper gastrointestinal endoscopy was used as the gold standard.Sensitivity and specificity,positive and negative predictive values,and positive and negative likelihood ratios were determined,with the cutoff points determined by receiver-operating characteristic curves.RESULTS:A total of 91 patients were included.The mean age was 53.75±12 years;50(54.9%)were men,and 41(45.0%)women.The etiology of cirrhosis included alcohol in 48(52.7%),virally induced in24(26.3%),alcoholism plus hepatitis C virus in three(3.2%),cryptogenic in nine(9.8%),and primary biliary cirrhosis in seven(7.6%).Esophageal varices were present in 73(80.2%)patients.Child-Pugh classification,17(18.6%)patients were classified as class A,37(40.6%)as class B,and 37(40.6%)as class C.The platelet count/spleen diameter ratio to detect esophageal varices independent of the grade showed using a cutoff value of≤884.3,had 84%sensitivity,70%specificity,and positive and negative predictive values of 94%and 40%,respectively.CONCLUSION:Our results suggest that the platelet count/spleen diameter ratio may be a useful tool for detecting esophageal varices in patients with hepatic cirrhosis. | Alejandro González-Ojeda Gabino Cervantes-Guevara Manuela Chávez-Sánchez Carlos Dávalos-Cobián Susana Ornelas-Cázares Michel Dassaejv Macías-Amezcua Mariana Chávez-Tostado Kenia Militzi Ramírez-Campos Anaís del Rocío Ramírez-Arce Clotilde Fuentes-Orozco | 2014 | World Journal of Gastroenterology2014，20，8： | 18 |
| 3 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 4 | Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans显示文摘 | Calbet J A L Mac Lean D A | 2002 | J Nutr2002，132，： | 1 |
| 5 | G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders:effects of diagnosis,suicide,and treatment at the time of death显示文摘 | Dowlatshahi D Mac Queen GM Wang JF Reiach JS Young LT | 1999 | J Neurochem1999，73，3： | 1 |
| 6 | Angiotensinconverting-enzyme gene polymorphisms,smoking and chronic obstructive pulmonary disease显示文摘 | Busquets X Mac Farlane NG Heine-Suer D | 2007 | Int J Chron Obstruct Pulmon Dis2007，2，3： | 1 |
| 7 | The effect of wind gusts, moisture content and fetch length on sand transport on a beach显示文摘 | Davidson-Arnotta R G D Mac Quarriea K Aagaardb T | 2005 | Geomorphology2005，68，： | 1 |
| 8 | Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication显示文摘 | Chen B Dowlatshahi D Mac Queen GM Wang JF Young LT | 2001 | Biol Psychiatry2001，50，4： | 1 |
| 9 | Elimination of false positives gene rated through PCR Re-amplification of differential display cDNA显示文摘 | Miele G Mac ReaL Mc Bride D | 1998 | Biol Techniques1998，25，： | 1 |
| 10 | A comparison be tween the high temperature electrode/electrolyte reactions of LixCoO2 and LixMn2O4显示文摘 | Hatchaid T D Dahn J R | 2001 | J Electrochem Soc2001，148，7： | 1 |
| 11 | Positive cloud toground lightning in mesoscalc convective system显示文摘 | Rutledge S A C Lu D R Mac Gorman | 1990 | J Atmos Sci1990，47，： | 1 |
| 12 | Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase inhibition 显示文摘 | Mac Keigan J P Taxman D J Hunter D | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 13 | Merging photoredox catalysis with organocatalysis:the direct asymmetric alkylation of aldehydes显示文摘 | Nicewicz D A Mac Millan D W C | 2008 | Science2008，322，： | 1 |
| 14 | Formation and degradation of dichloroacetonitrile in drinking waters显示文摘 | Reckhow D A Mac Neill A L Platt T L | 2001 | Journal of Water Supply:Research and Technology Aqua2001，50，1： | 1 |
| 15 | Wildfire-produced charcoal directly influences nitrogen cycling in ponderosa pine forests 显示文摘 | Deluca T H Mac Kenzie M D Gundale M J | 2006 | Soil Science Society of America Journal2006，70，： | 1 |
| 16 | Evaluation of Brnsted sites inside the H-MOR employing NH3: A theoretical study显示文摘 | DíAZ L SIERRAALTA A NASCIMENTO MAC A | 2013 | J Phys Chem C2013，117，10： | 1 |
| 17 | The Texas Children’s Hos-pital Pediatric Advanced Warning Score as a Predictor ofClinical Deterioration in Hospitalized Infants and Children:A Modification of the PEWS Tool显示文摘 | Bell D Mac A Ochoa Y | 2013 | J Pediatr Nurs2013，28，6： | 1 |
| 18 | Carbamazepine oxidation catalyzed by manganese porphyrins:Effects of theβ-bromination of the macrocycle and the choice of oxidant显示文摘 | Carvalhoda S D Mac L T Cristina O | 2011 | Applied Catalysis A:General2011，408，12： | 1 |
| 19 | Variation in nitrogen use efficiency among soft red winter wheat genotypes 显示文摘 | Van Sanford D A Mac Kown C T | 1986 | Theoretical and Applied Genetics1986，72，： | 1 |
| 20 | Adsorption and dissolution behavior of human plasmafibronectinon thermallyand chemicallymodified titaniumdioxide particles显示文摘 | Mac DONALD D E DEO N MARKOVIC B | 2002 | Biomaterials2002，23，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员