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| 1 | Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents显示文摘Objectives To explore the optimal threshold values of waist circumference(WC)for detecting cardiovascular(CV)risk factors among Chinese children and adolescents.Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China.CV risk factors in this study included hypertension(blood pressure above 95 percentile levels),dyslipidemia(with one or more of the following three indexes:TG≥1.7 mmol/L,TC≥5.18 mmol/L,and HDL-C≤1.04 mmol/L)and elevated glucose level(fasting plasma glucose ≥5.6 mmol/L).Receive-operating characteristic analysis(ROC)and logistic regression were employed to derive optimal age-and sex-specific waist circumference references for predicting CV risk factors.Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population,while a remarkable increasing trend occurred from the 90th percentile.The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls,which was at the 90th percentiles for detecting at least two of the above three CV risk factors.In comparison with children with waist circumference below the 75th percentile,the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile,and increased by 6 times among children with waist circumference above the 90th percentile.The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category.Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents,respectively. | GUAN-SHENG MA CHENG-YE JI JUN MA JIE MI R1TA YT SLING FENG XIONG WEI-LI YAN XIAO-QI HU YAN-PING LI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG | 2010 | Biomedical and Environmental Sciences2010，23，1： | 25 |
| 2 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 3 | Discrimination of abiogenic and biogenic alkane gases显示文摘We have combined the analytical data of the carbon isotope distribution pattern, R/Ra and CH4/3He values of abiogenic and biogenic (referring to the thermogenic and bacterial or microbial) alkane gases in China with those of alkane gases from USA, Russia, Germany, Australia and other countries. Four discrimination criteria are derived from this comparative study: 1) Carbon isotopic composition is generally greater than -30‰ for abiogenic methane and less than -30‰ for biogenic methane; 2) Abiogenic alkane gases have a carbon isotopic reversal trend (δ 13C1> δ 13C2> δ 13C3> δ 13C4) with δ 13C1>-30‰ in general; 3) Gases with R/Ra >0.5 and δ 13C11 δ 13C2>0 are of abiogenic origin; 4) Gases (meth- ane) with CH4/3He≤106 are of abiogenic origin, whereas gases with CH4/3He≥1011 are of biogenic origin. | DAI JinXing ZOU CaiNeng ZHANG ShuiChang LI Jian NI YunYan HU GuoYi LUO Xia TAO ShiZhen ZHU GuangYou MI JingKui LI ZhiSheng HU AnPing YANG Chun ZHOU QingHua SHUAI YanHua ZHANG Ying MA ChengHua | 2008 | Science China Earth Sciences2008，51，12： | 17 |
| 4 | The global significance of biodiversity science in China: an overview显示文摘Biodiversity science in China has seen rapid growth over recent decades,ranging from baseline biodiversity studies to understanding the processes behind evolution across dynamic regions such as the Qinghai-Tibetan Plateau.We review research,including species catalogues;biodiversity monitoring;the origins,distributions,maintenance and threats to biodiversity;biodiversity-related ecosystem function and services;and species and ecosystems'responses to global change.Next,we identify priority topics and offer suggestions and priorities for future biodiversity research in China.These priorities include(i)the ecology and biogeography of the Qinghai-Tibetan Plateau and surrounding mountains,and that of subtropical and tropical forests across China;(ii)marine and inland aquatic biodiversity;and(iii)effective conservation and management to identify and maintain synergies between biodiversity and socio-economic development to fulfil China's vision for becoming an ecological civilization.In addition,we propose three future strategies:(i)translate advanced biodiversity science into practice for biodiversity conservation;(ii)strengthen capacity building and application of advanced technologies,including high-throughput sequencing,genomics and remote sensing;and(iii)strengthen and expand international collaborations.Based on the recent rapid progress of biodiversity research,China is well positioned to become a global leader in biodiversity research in the near future. | Xiangcheng Mi Gang Feng Yibo Hu Jian Zhang Lei Chen Richard T.Corlett Alice C.Hughes Stuart Pimm Bernhard Schmid Suhua Shi Jens-Christian Svenning Keping Ma | 2021 | National Science Review2021，8，7： | 16 |
| 5 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 6 | Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling显示文摘穿过种类障碍感染人的很少鸟的流行性感冒病毒,高度病原的流行性感冒 A (H5N1 ) 紧张夺走生活多于感染的病人的一半。与由 H5N1 感染的肺损害的大部分未知的机制,尖锐呼吸悲痛症候群(ARDS ) 是在牺牲品之中的死亡的主要原因。这里我们在场 H5N1 通过 mTOR 的抑制引起了 autophagic 房间死亡的事实发信号。由 autophagy 基因 Beclin1 的弄空或由 autophagy 禁止者 3-methyladenine (3 麻省) , autophagy 的抑制显著地减少了 H5N1 调停的房间死亡。我们建议 autophagic 房间死亡可以在 H5N1 流行性感冒病人贡献 ARDS 的发展, autophagy 的抑制能因此为 H5N1 感染的治疗成为新奇策略。 | Jianhui Ma Qian Sun Ruifang Mi Hongbing Zhang | 2011 | Journal of Genetics and Genomics2011，38，11： | 13 |
| 7 | Synchronization and wave propagation in neuronal network under field coupling显示文摘Electric and chemical synapse play important role in connecting neurons and thus signal propagation can be realized between neurons. External electric stimulus can change the excitability of neuron and then the electrical activities can be modulated completely. Continuous fluctuation of ion concentration in cell can induce complex time-varying electromagnetic field during the exchange of charged ions across the membrane of neuron. Polarization and magnetization in the media(and neuron), which exposed to electromagnetic radiation, can modulate the dynamical response and mode transition in electrical activities of neurons. In this paper, magnetic flux is used to describe the effect of electromagnetic field, and the three-variable HindmarshRose neuron model is updated to propose a four-variable neuron model that the effect of electromagnetic induction and radiation can be explained. Based on the physical law of electromagnetic induction, exchange of charged ions and flow of ion currents will change the distribution of electromagnetic filed in cell, and each neuron will be exposed to the superimposed field triggered by other neurons. Therefore, signal exchange could occur even synapse coupling between neurons is removed in the case of field coupling. A chain network is proposed to investigate the signal exchange between neurons under field coupling when synapse coupling is not available. It is found that field coupling between neurons can change the collective behaviors in electrical activities. A statistical factor of synchronization and spatial patterns are calculated, these results confirmed that field coupling is effective for signal communication between neurons. In the end, open problems are suggested for readers' extensive guidance in this field. | LV Mi MA Jun YAO YuanGen ALZAHRANI Faris | 2019 | Science China(Technological Sciences)2019，62，3： | 12 |
| 8 | Phylogenetic beta diversity in tropical forests: Implications for the roles of geographical and environmental distance显示文摘社区汇编的各种各样的机械学的理论被建议了从基于壁龛的理论到中立理论。在种系发生的上下文的贝它差异的分析能为这些假设测试许多提供一个优秀机会。我们在巴拿马在热带树社区分析了种系发生的贝它差异的模式测试几个社区集会假设。特别地,在社区之间的种系发生的不同能被地理或环境的距离向解释的度能分别地为随机或确定的集会过程产出支持。因此,我们检验了:在社区和它从那的离开的度之中的种系发生的类似的距离腐烂的存在在一个空模型下面期望的(i) ;并且(ii ) 在预言社区的种系发生的不同的地理对环境的距离的相对重要性。我们发现了社区的种系发生的作文的类似与地理距离和环境坡度腐烂了的证据。空模型证据证明在学习系统的那贝它差异是种系发生地非随机的。我们的结果加亮本地生态的机制的角色不仅包括环境过滤和竞争排除,而且 biogeographical 过程象在组织种系发生的周转的种形成,疏开限制,和壁龛进化那样。这些结果也在组织种类差异模式强调壁龛保守主义的重要性。 | Jin-Long ZHANG Nathan G. SWENSON Sheng-Bin CHEN Xiao-Juan LIU Zong-Shan LI Ji-Hong HUANG Xiang-Cheng MI Ke-Ping MA | 2013 | Journal of Systematics and Evolution2013，51，1： | 11 |
| 9 | RNA Interference-mediated Silencing of Phytochelatin Synthase Gene Reduce Cadmium Accumulation in Rice Seeds显示文摘Phytochelatins (PC ) 玩在重金属抵抗和累积的一个重要角色。到在大米的镉(Cd ) 的累积播种的还原剂,表示 ofphytochelatin synthase (PCS ) 基因 OsPCSI 被 RNAinterference (RNAi ) 压制。PCS 碎片的发卡构造在控制 ofZMM1 下面在 pRNAi-OsPCS1 被设计,从玉米的 aseed 特定的倡导者。构造被介绍进米饭(装饰用的梨树) throughAgrobacteriumtumefaciens。RNAi 米饭小植物在壶 exposured to10 mg/kg Cd 被选择并且栽培。OsPCSI 的 transcriptionallevel 与野生型相比在一些 RNAi 米饭的种子衰退了。作为结果 Cd 累积被减少由关于在 RNAi 大米的种子的一半。Asexpected,生长的明显的差别都没出现在 RNAiand 野类型的工厂之间。结果建议这条新途径能被用来在庄稼控制重金属累积。 | Jiang-Chuan Li Jiang-Bo Guo Wen-Zhong Xu Mi Ma | 2007 | Journal of Integrative Plant Biology2007，49，7： | 11 |
| 10 | Solution-processed copper nanowire flexible transparent electrodes with PEDOT:PSS as binder, protector and oxide-layer scavenger for polymer solar cells显示文摘nanowire (NW ) 拍摄的 Cu 的容易的氧化和表面粗糙是为他们在透明传导性的电极(TCE ) 的用法的主要瓶颈。此处,我们开发了一条灵巧、可伸缩起来的答案线路准备 Cu 由把 Cu NW 嵌进的基于 NW 的 TCE pre 涂 poly 变光滑(3,4-ethylenedioxythiophene ): poly (styrenesulfonate )(PEDOT : PSS ) 电影在上 poly (乙烯 terephthalate )( 宠物) 底层。那么获得的 Cu NW-PEDOT : PSS/PET 电影有低表面粗糙(在高度的 70 nm ) ,向氧化的高稳定性和好灵活性。最佳的 TCE 显示出 15 猯'T? 的一个典型的表电阻 ?? | Jianyu Chen Weixin Zhou Jun Chen Yong Fan Ziqiang Zhang Zhendong Huang Xiaomiao Feng Baoxiu Mi Yaowen Ma Wei Huang | 2015 | Nano Research2015，8，3： | 10 |
| 11 | New aspects in celiac disease显示文摘Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis. | MI Torres MA López Casado A Ríos | 2007 | World Journal of Gastroenterology2007，13，8： | 10 |
| 12 | Effect of moxa-burning heat stimulating Liangmen(ST 21) and Zusanli(ST 36) on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer显示文摘OBJECTIVE: To observe the effect of moxa-burning heat stimulating acupoints of Liangmen(ST 21)and Zusanli(ST 36) on the proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer.METHODS: Forty rats were randomly divided into four groups: negative control(NC), ulcer control(UC), acupoints of stomach meridian(ASM), and acupoints control(AC). The acute gastric ulcer model was established by bound and water immersion.Rats in NC and UC groups didn't receive any moxa-burning heat stimulating treatment, while rats in ASM and AC groups were treated with buringmoxa heat stimulating the acupoints of Liangmen(ST 21) and Zusanli(ST 36) and their controlled points, respectively. Rats in all groups were sacrificed after 12 consecutive days treatment. The ulcer index was evaluated by using Guth's method.The expression of tumor necrosis factor-alpha(TNF-α), apoptotic protease activating facter-1(Apaf-1), Caspase-3, p21 activated kinase 1(PAK1),extracellular regulated protein kinases 2(ERK2),phosphorylated ERK2(p ERK2), phosphoinositide3-kinase(PI3K) and RAC-alpha serine/threonine-protein kinase(Akt) in gastric mucosa was detected by enzyme linked immunosorbent assay(ELISA).RESULTS: Compared with UC group, the ulcer index of ASM and AC groups decreased, and the injured gastric mucosa was improved, the expression of TNF-α, Apaf-1 and Caspase-3 in gastric mucosa was significantly reduced(P < 0.05), while the ex-pression of PAK1, ERK2, p ERK2, PI3 K and Akt in gastric mucosa was significantly increased(P < 0.05).And ASM showed better effect than AC group(P <0.05).CONCLUSION: Moxa-burning Heat stimulating of Liangmen(ST 21) and Zusanli(ST 36) could promote the recovery of gastric mucosal lesion probably by inhibiting cell apoptosis and promoting cell proliferation in stress-induced gastric ulcer. | Peng Li Wang Yadong Chang Xiaorong Wu Huangan Liu Mi Ma Fuqiang Wang Hong Chen Jiaolong Wang Chao Quan Renfu Yang Zongbao | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 9 |
| 13 | Comparison of phylobetadiversity indices based on community data from Gutianshan forest plot显示文摘Phylobetadiversity incorporates phylogenetic information and beta diversity,and can account for the ecological similarities between communities with a phylogenetic perspective.Although different phylobetadiversity indices reflect differences in different characteristics between communities,the results of different phylobetadiversity indices are not comparable.In this study we examined phylobetadiversity indices for a 24-hm 2 plot in the Gutianshan National Nature Reserve.It was found the abundanceweighted D pw was almost identical to Rao's D of Rao's quadratic entropy.PhyloSor had a similar ecological meaning and algorithm to UniFrac.Although Dnn was different in definition from UniFrac and PhyloSor,they were all strongly correlated.The effect of species abundance on phylobetadiversity was not significant when scales were relatively small,but was significant at larger scales.These contrasts likely resulted from reductions in evenness in communities as scales increased.P ST and Rao's H better reflected the distance-decay changes caused by spatial and habitat variation than other indices at larger scales,whereas AW-D nn and D nn better reflected these changes at small scales. | FENG Gang ZHANG JinLong PEI NanCai RAO MiDe MI XiangCheng REN HaiBao MA KePing | 2012 | Chinese Science Bulletin2012，57，6： | 9 |
| 14 | Evidence of vacuolar compartmentalization of arsenic in the hyperaccumulator Pteris vittata显示文摘Pteris vittata can hyperaccumulate arsenic (As) to >1% of its dry weight without showing any signs of toxicity, indicating the existence of effective plant-internal detoxification mechanisms. Although vacuolar compartmentalization is known to play an important role in heavy metal detoxification and tolerance, direct evidence of arsenic compartmentalization in this hyperaccumulator was lacking. Here we report the subcellular localization of As in the callus of P. vittata. The callus induced from gametophytes of P. vittata exposed to 0.2 mmol/L arsenate for 20 days were examined by directly isolating cell walls, protoplasts and vacuoles, and determining arsenic concentrations. Of the total As in the callus, about 94% was in the protoplast, and of that, 91% was present in the vacuoles, indicating that vacuoles are a major storage site for As in P. vittata. In addition, the changes in the chemical components of vacuoles were analyzed by Fourier transform infrared spectroscopy (FTIR). | YANG XueXi CHEN Hui DAI XiaoJing XU WenZhong HE ZhenYan MA Mi | 2009 | Chinese Science Bulletin2009，54，22： | 8 |
| 15 | Enhanced Cadmium Accumulation in Transgenic Tobacco Expressing the Phytochelatin Synthase Gene of Cynodon dactylon L显示文摘Bermudagrass (L 上的 Cynodon 扬抑抑格。cv。Goldensun ) 对高度抵抗并且积累大量镉(Cd ) 。phytochelatin synthase (PCS ) cDNA (CdPCSI ) 被 cDNA 结束的快速的扩大从这棵草孤立。通常认为的 CdPCSI 蛋白质从另外的植物与 PCS 分享了高相同,与在 N 终端的 79% 相同和在 theC 终端的 47% 相同。然而, 16 Cys 残余在 CdPCS1 的 C 终端被发现,并且在这些残余之中,三个位置与另外的 PCS 蛋白质不同。Semiquantitative reversetranscription 聚合酶链反应分析证明 Cd 应力在 Bermudagrass 在根和叶子导致了 CdPCSI 表示。我们证实 CdPCSI 由在 ABDE1 表示基因在酵母房间在 Cdtolerance 起一个重要作用, Cd 敏感的异种。CdPCSI 然后被介绍进烟草植物。在某转基因的烟草的 phytochelatin 水平在野生型植物非常衬里 increased3.88 褶层,在这些转基因的植物的 Cd 累积因此是 enhanced3.21 褶层。结果建议 CdPCSI 以后能为植物救治被用作一个基因要素。 | Jiangchuan Li Jiangbo Guo Wenzhong Xu Mi Ma | 2006 | Journal of Integrative Plant Biology2006，48，8： | 8 |
| 16 | Antiglycation,antioxidant and toxicological potential of polyphenol extracts of alligator pepper,ginger and nutmeg from Nigeria显示文摘Objective:To evaluate the antioxidant and antiglycation potential of polyphenols from three spices;alligator pepper,ginger and nutmeg.Methods:Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay,phyloloxicily test,DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay.Results:Results obtained showed that polyphenol extract of ginger has the highest anlioxidant potential with IC_(50)0.075 and 0.070 mg/mL.for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC_(50)0.125 mg/mL.However,nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD_(50)4359.70 and 1490μg/mL respectively.Conclusions:It can be concluded that the polyphenol extracts of alligator pepper,ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are,safe for consumption. | Kazeem MI Akanji MA Hafizur Rahman M Choudhary MI | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 7 |
| 17 | Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries显示文摘Soft tissue injury is very common and associated with pain,tissue swelling and even malformation if not treated on time.Treating methods include cryotherapy,electrical therapy,ultrasound therapy and anti-inflammatory drug,but none of them is completely satisfying.In this work,for a better therapeutic effect,drug therapy and pulsed electromagnetic field(PEMF)therapy were combined.We constructed a drug delivery system using the tetra-PEG/agar hydrogel(PA).By incorporating Fe3O4 NPs into the hydrogel network,a magnetism-responsive property was achieved in the system.The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel.A magnetism-controlled release was attained by the incorporation of Fe3O4.Finally,in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue.Therefore,this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury. | Lining Zhang Xiuqin Zuo Shengjie Li Mi Sun Huimin Xie Kai Zhang Jikun Zhou Liyun Che Junxuan Ma Zishan Jia Fei Yang | 2019 | Bioactive Materials2019，4，1： | 7 |
| 18 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 19 | Integration of SAR Polarimetric Features and Multi-spectral Data for Object-Based Land Cover Classification显示文摘An object-based approach is proposed for land cover classification using optimal polarimetric parameters.The ability to identify targets is effectively enhanced by the integration of SAR and optical images.The innovation of the presented method can be summarized in the following two main points:①estimating polarimetric parameters(H-A-Alpha decomposition)through the optical image as a driver;②a multi-resolution segmentation based on the optical image only is deployed to refine classification results.The proposed method is verified by using Sentinel-1/2 datasets over the Bakersfield area,California.The results are compared against those from pixel-based SVM classification using the ground truth from the National Land Cover Database(NLCD).A detailed accuracy assessment complied with seven classes shows that the proposed method outperforms the conventional approach by around 10%,with an overall accuracy of 92.6%over regions with rich texture. | Yi ZHAO Mi JIANG Zhangfeng MA | 2019 | Journal of Geodesy and Geoinformation Science2019，2，4： | 7 |
| 20 | Constituent and effects of polysaccharides isolated from Sophora moorcroftiana seeds on lifespan,reproduction,stress resistance,and antimicrobial capacity in Caenorhabditis elegans显示文摘Sophora moorcroftiana(S. moorcroftiana) is an endemic leguminous dwarf shrub in Tibet, China. Decoctions of the seeds have been used in Chinese folk medicine for dephlogistication, detoxication, and infectious diseases. The present study aimed to investigate the constituent and biological effects of polysaccharides from S. moorcroftiana seeds in Caenorhabditis elegans(C. elegans). Polysaccharides from S. moorcroftiana seeds(SMpol) were extracted with 60% ethanol and constituent was analyzed by GC-MS. SMpol was composed of glucose, galactose and inositol in the molar ratio of 35.7 : 1.3 : 17.0. Synchronized worms were treated with SMpol and then lifespan, motility, reproduction, stress resistance and antimicrobial activity were examined. Compared with the control group, the lifespan was increased to the average of 27.3 days and the number of laying eggs showed a 1.3-fold increase in nematodes treated with SMpol(4 mg×mL^(–1)). In SMpol(4 mg×mL^(–1)) treated worms, there was a 1.1-fold increase in 24-h survival of acute heat stress and a 1.6-fold increase in 2-h survival of oxidative stress The colonization of the bacteria in the SMpol treated nematode was significantly lower than that of the untreated group by 68.3%. In vivo studies showed SMpol significantly extended the life span, improved reproduction, increased stress resistance and antimicrobial capacity of C. elegans. In conclusion, those results indicated that the polysaccharides from S. moorcroftiana seeds were involved in a variety of biological activities leading to its modulatory effects on C. elegans which may be developed as a natural supplement agent. | ZHANG Yuan MI Dan-Yang WANG Jin LUO Yan-Ping YANG Xu DONG Shi MA Xing-Ming DONG Kai-Zhong | 2018 | Chinese Journal of Natural Medicines2018，16，4： | 6 |
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