| 3 | Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism显示文摘Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of glucose availability in cells.Now,a small metabolite of the glycolytic pathway,dihydroxyacetone phosphate,has been identified by Sabatini and his coworkers,who show how mTORC1-activity is regulated in glucose-starved and replenished cancer cells. | Angela M.Otto | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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