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| 1 | Altered Endothelin-1 Signaling in Production of Thromboxane A_(2) in Kupffer Cells from Bile Duct Ligated Rats显示文摘Kupffer cells(KCs),the liver resident macrophages accounting for 80-90%of the total population of fixed tissue macrophages in the body,not only play a key role in host defense via removing particulate materials from the portal circulation,but may also contribute to the pathogenesis of various liver diseases.We have previously demonstrated that KCs play an important role in controlling portal hypertension and hepatocellular injury via releasing thromboxane A_(2)(TXA_(2))in early fibrosis induced by one-week bile duct ligation(BDL).Production of TXA_(2) is controlled by cytosolic phospholipase A_(2)(cPLA_(2))that is activated by the interaction of entothelin-1(ET-1)with its G-protein coupled ET receptor B(ETBR).However,the signaling pathways that contribute to the ET-1-induced activation of cPLA_(2) and production of TXA_(2) in KCs in the normal healthy or injured livers are not yet clear,which are investigated in the present study using isolated KCs from one-week BDL or sham rats.The pharmacological inhibition of cPLA_(2) or chelation of intracellular calcium abrogated the ET-1 induction of TXA_(2) from KCs.Compared to those from sham rats,KCs from BDL animals displayed a significantly enhanced responsiveness of p38 MAPK to ET-1,increased ETBR and Gai subunit but decreased Gaq and Ga11 expression.Inhibition of ERK1/2 or Gq signaling abrogated significantly the ET-1 induction of TXA_(2) in sham KCs but only slightly in BDL KCs.In contrast,inhibition of p38 MAPK and Gi signaling markedly attenuated the ET-1 induction of TXA_(2) in BDL KCs but had no effect in sham KCs.Lastly,inhibition of PLC or PKC abrogated ET-1 induction of TXA_(2) in KCs from both sham and BDL groups.The hepatic stress(such as BDL)induces significant modifications in the receptor and intermediates of ET-1 signaling in KC and subsequently alters ET-1 signaling mechanisms,particularly a shift from Gq induced signaling to Gi induced signaling,in the activation of cPLA_(2) and production of TXA_(2) in response to ET-1. | Andrew M.Miller Jian X.Zhang | 2009 | Cellular & Molecular Immunology2009，6，6： | 4 |
| 2 | Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression.Use of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced changes.In the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A mouse.Following these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage gait.As the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits appeared.We next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A survival.We identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates:a fast progression group and a slow progression group.This behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease severities.This affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease progression.Such factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms. | Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones | 2017 | Neural Regeneration Research2017，12，10： | 3 |
| 3 | The Cost of Capital,Corporation Finance and the Theory of Investment显示文摘 | Modigliani F M.Miller | | 0，，： | 1 |
| 4 | The Cost of Capital,Corporate Finance and the Theory of Investment显示文摘 | Modigliani.F M.Miller | | 0，，03： | 1 |
| 5 | Examining the Mediators of Agenda Setting: A New Experimental Paradigm Reveals the Role of Emotions显示文摘 | Joanne M.Miller | 2007 | Political Psychology2007，，6： | 1 |
| 6 | Molecular mechanisms of alcoholic liver disease:Innate immunity and cytokines显示文摘 | Andrew M.Miller Norio Horiguchi Won-IL Jeong | | 0，，5： | 1 |
| 7 | The Cost of Capital,Corporation Finance and the Theory of Investment显示文摘 | Modigliani F M.Miller | | 0，，03： | 1 |
| 8 | Long-term Staar Toric Intraocular Lens Rotational Stability显示文摘 | Mario J Michael D.Olson Kevin M.Miller | | 0，，： | 1 |
| 9 | 减轻蓄热室堵塞的新型熔铸格子砖设计方案及其试验显示文摘1前言
35年来,玻璃熔窑的性能已有了长足的进展,燃料的消耗量已减少了约75%.即每公斤玻璃液平均耗量从1960年的500g减少至现在的120 g.窑龄由约7年延长至大约15年.尽管如此,蓄热室格子体堵塞和清扫仍是玻璃生产企业十分关注的问题[1].一旦蓄热室格子体发生堵塞,肯定会降低蓄热室工作效率,增加燃料的消耗量,进而造成运行状态恶化. | Y.Boussant-Roux O.Citti M.Miller S.Chaudourne 陈恭源 | 2004 | 玻璃2004，31，3： | 1 |
| 10 | 恒星形成活动区的亚毫米谱线观测和研究显示文摘用KOSMA 3 m毫米-亚毫米波望远镜对B35, S146和TMC-2A进行了12CO(J = 3 - 2)谱线的成图观测, 结果表明这3个区域都存在高速分子外向流. 求出了其物理和动力学参量, 并分析了外向流的形态及其与红外源的成协性. 另外, 谱线的中心速度分布表明, 这3个源都存在大尺度的速度梯度. 计算分析排除了外向流等成因, 说明速度梯度由它们的云核旋转引起. TMC-2A中还存在中心核区与大尺度上速度梯度相反的反转现象, 这可能由磁滞造成. 最后计算了云核的旋转角速度, 并讨论了旋转在抗衡分子云的引力塌缩和减缓恒星形成率方面的重要作用. | 江林华 吴月芳 M.Miller | 2001 | 科学通报2001，46，18： | 1 |
| 11 | Relaxation of canine gallbladder to nerve stimulation involves adrenergic and non‐adrenergic non‐cholinergic mechanisms显示文摘 | S.Alcón S.Morales P. J.Camello G. M.Salido S. M.Miller M. J.Pozo | 2002 | Neurogastroenterology & Motility2002，，6： | 1 |
| 12 | Liquidity and Market Structure显示文摘 | Grossman S M.Miller | | 0，，： | 1 |
| 13 | The cost of capital,corporation finance and the theory of investment显示文摘 | Modigliani F M.Miller | | 0，，： | 1 |
| 14 | Evaluating the Argentine Supreme Court under Presidents Alfonsin and Menem (1983-1999)显示文摘 | Jonathan M.Miller | | 0，，02： | 1 |
| 15 | Evaluating the Argentine Supreme Court under Presidents Alfonsin and Menem (1983-1999)显示文摘 | Jonathan M.Miller | | 0，，02： | 1 |
| 16 | Characterization of hybridoma cell responses to elevated pCO<sub>2</sub> and osmolality: Intracellular pH, cell size, apoptosis, and metabolism显示文摘 | Vivian M.deZengotita Albert E.Schmelzer William M.Miller | 2002 | Biotechnol Bioeng2002，，4： | 1 |
| 17 | Probing star formation and feedback using CCOSMA and archival data in the CFG028.68–0.28 quasi-sinusoidal filament显示文摘We have performed a multi-wavelength study toward a quasi-sinusoidal filament(CFG028.68–0.28). A new large-scale ^12CO J = 3-2 map was obtained from the China-Cologne Observation for Sub Millimeter Astronomy(CCOSMA) 3m radio telescope. Based on the ATLASGAL catalog, we have identified 27 dust clumps in the filament. Through the relationship between the mass and radius of these clumps, 67% of these clumps are dense and massive enough to potentially form massive stars. The obtained CFE is ~11% in the filament. The filament has a linear mass density of ~305 M⊙pc^-1, which is smaller than its critical mass to length ratio. This suggests that the external pressure from the neighboring H Ⅱ regions may help prevent the filament from dispersing under the effects of turbulence. Comparing the energy injection from outflows and H Ⅱ regions in the filament, the ionization feedback from the H Ⅱ regions can help maintain the observed turbulence. | Jin-Long Xu Jirgen Stutzki Yuefang Wu Xin Guan Jun-Jie Wang M.Miller Yang Chen Sheng-Li Qin Jun-Zhi Wang Chang-Chun Ning Danzengluobu Tian-Lu Chen Nai-Ping Yu Chuan-Peng Zhang Xiao-Lan Liu Jian-Bin L Karl Jacobs Urs UGraf Gang Xu Nan Li Guo-Yin Zhang and Qi Wu | 2019 | Research in Astronomy and Astrophysics2019，19，12： | 0 |
| 18 | Nucleation of recrystallization in magnesium alloy grains of varied orientation and the impacts on texture evolution显示文摘Selection of appropriate thermomechanical processing parameters is crucial for control of the crystallographic texture and grain size distribution in wrought magnesium alloys, which in turn dictate their mechanical properties. In this work, the recrystallization behavior of binary Mg-Zn alloys are examined after warm rolling as a function of alloy content and heat treatment temperature. The Avrami exponent increased with increasing heat treatment temperature up to the Mg Zn solvus, while the strength of the recrystallization texture decreased.Neither the Avrami exponent nor the qualitative trends in texture evolution were sensitive to the Zn alloying content in the examined range.EBSD and transmission electron microscopy observations revealed that the changes in texture and recrystallization kinetics could be attributed to differences in the nucleation behavior of basal and off-basal orientations. | Victoria M.Miller Jian-Feng Nie Tresa M.Pollock | 2022 | Journal of Magnesium and Alloys2022，10，11： | 0 |
| 19 | 打击网络假冒的创新解决方案显示文摘在造假者利用Google、Twitter、Facebook等网络新平台开发造假新阵地的时候,权利人也应该利用这些网络新宠们进行反击
2012年6月27日,爱马仕CEO帕特里克·托马斯在接受媒体采访时无奈地表示,"网络代购中80%的爱马仕都是假冒产品。"同一天,从中国深圳市药监局新闻发布会上透出消息,该局近期查处的制售假药大要案三成涉及网络,且网络销售假药牵出来的往往是面向全国的巨大销售网络。显而易见,互联网成为人们购物重要渠道的同时,也成了假冒产品的新乐园。 | Jonathan Gelfand Camille M.Miller Elizabeth Featherman | 2012 | 法人2012，，7： | 0 |
| 20 | Neonatal seizures and disruption to neurotransmitter systems显示文摘Seizure disorders and epilepsies are well documented to be associated with long-term neurological and cognitive deficits in the adult and pediatric patients,but what about seizures in the newborn?The neonatal brain is highly susceptible to seizures,with hypoxic-ischemic encephalopathy(HIE)the most com- | Stephanie M.Miller Kate Goasdoue S.Tracey Bjorkman | 2017 | Neural Regeneration Research2017，12，2： | 0 |
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