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| 1 | A novel color image encryption algorithm based on a fractional-order discrete chaotic neural network and DNA sequence operations显示文摘A novel color image encryption algorithm based on dynamic deoxyribonucleic acid(DNA)encoding and chaos is presented.A three-neuron fractional-order discrete Hopfield neural network(FODHNN)is employed as a pseudo-random chaotic sequence generator.Its initial value is obtained with the secret key generated by a fiveparameter external key and a hash code of the plain image.The external key includes both the FODHNN discrete step size and order.The hash is computed with the SHA-2 function.This ensures a large secret key space and improves the algorithm sensitivity to the plain image.Furthermore,a new three-dimensional projection confusion method is proposed to scramble the pixels among red,green,and blue color components.DNA encoding and diffusion are used to diffuse the image information.Pseudo-random sequences generated by FODHNN are employed to determine the encoding rules for each pixel and to ensure the diversity of the encoding methods.Finally,confusion II and XOR are used to ensure the security of the encryption.Experimental results and the security analysis show that the proposed algorithm has better performance than those reported in the literature and can resist typical attacks. | Li-ping CHEN Hao YIN Li-guo YUAN António M.LOPES J.A.Tenreiro MACHADO Ran-chao WU | 2020 | Frontiers of Information Technology & Electronic Engineering2020，21，6： | 5 |
| 2 | Ductus venosus blood flow assessment at 11 to 14 weeks of gestation and fetal outcome显示文摘 | J. M.Toyama M. L.Brizot A. W.Liao L. M.Lopes R. M. Y.Nomura F. A. T.Saldanha M.Zugaib | 2004 | Ultrasound Obstet Gynecol2004，，4： | 1 |
| 3 | Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system显示文摘Many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterised by the accumulation of misfolded protein deposits in the brain, leading to a progressive destabilisation of the neuronal network and neuronal death. Among the proteins that can abnormally accumulate are tau and α-synuclein, which can propagate in a prion-like manner and which upon aggregation, represent the most common intracellular proteinaceous lesions associated with neurodegeneration. For years it was thought that these intracellular proteins and their accumulation had no immediate relationship with extracellular homeostasis pathways such as the glymphatic clearance system;however, mounting evidence has now suggested that this is not the case. The involvement of the glymphatic system in neurodegenerative disease is yet to be fully defined;however, it is becoming increasingly clear that this pathway contributes to parenchymal solute clearance. Importantly, recent data show that proteins prone to intracellular accumulation are subject to glymphatic clearance, suggesting that this system plays a key role in many neurological disorders. In this review, we provide a background on the biology of tau and α-synuclein and discuss the latest findings on the cell-to-cell propagation mechanisms of these proteins. Importantly, we discuss recent data demonstrating that manipulation of the glymphatic system may have the potential to alleviate and reduce pathogenic accumulation of propagation-prone intracellular cytotoxic proteins. Furthermore, we will allude to the latest potential therapeutic opportunities targeting the glymphatic system that might have an impact as disease modifiers in neurodegenerative diseases. | Douglas M.Lopes Sophie K.Llewellyn Ian F.Harrison | 2022 | Translational Neurodegeneration2022，11，1： | 1 |
| 4 | mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics显示文摘 | H.Pópulo P.Soares A.Faustino A. S.Rocha P.Silva F.Azevedo J. M.Lopes | 2011 | Pigment Cell & Melanoma Research2011，，： | 1 |
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