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| 1 | Diet and medical foods in Parkinson’s disease显示文摘Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder with motor and non-motorsigns, which begins long before the diagnosis can be made. Pharmacotherapy with dopaminergic drugsis the mainstay of PD therapy. There is no currently available cure or disease-modifying treatment. Dietand various foods have been proposed as possible risk factors for PD. Nutritional supplementation withomega-3 fatty acids, vitamin D, B vitamins, and coenzyme Q may have potential in the management ofPD. In addition, several strategies could possibly lead to the development of medical foods in PD. Forexample, ketogenic diets may have effects complementary to pharmacotherapy. Gut microbial dysbiosisand altered microbial metabolites found in PD may lead to chronic low-grade inflammation in gut andbrain. Interventions targeting gut microbiota, such as the supplementation of probiotics, may providenovel approaches to PD in regard to both symptomatic treatment and disease modification. High qualityrandomized controlled trials need to be conducted in order to evaluate whether these food-basedstrategies have symptomatic efficacy or the potential to delay the progression of PD. | Klaus W.Lange Yukiko Nakamura Ning Chen Jianjun Guo Shigehiko Kanaya Katharina M.Lange Shiming Li | 2019 | Food Science and Human Wellness2019，8，2： | 2 |
| 2 | Origin of presacral local recurrence after rectal cancer treatment显示文摘 | M.Kusters C.Wallner M. M.Lange M. C.DeRuiter C. J. H.van de Velde Y.Moriya H. J. T.Rutten | 2010 | Br J Surg2010，，10： | 1 |
| 3 | Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence显示文摘Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge worldwide.The symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the disorder.The potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of AD.Numerous mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical studies.However,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are scarce.While epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these observations.The clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea. | Klaus W.Lange Katharina M.Lange Yukiko Nakamura | 2022 | Food Science and Human Wellness2022，11，4： | 1 |
| 4 | Origin of presacral local recurrence after rectal cancer treatment显示文摘 | M.Kusters C.Wallner M. M.Lange M. C.DeRuiter C. J. H.van de Velde Y.Moriya H. J. T.Rutten | 2010 | Br J Surg2010，，10： | 1 |
| 5 | Medical foods in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most prevalent cause of dementia worldwide.Treatments achieving a marked improvement in symptoms or preventing or delaying the progression of the disease are not available.Various diet-related risk factors for AD have been identified.Evidence for a protective effect of the Mediterranean diet on AD risk is inconclusive.Medical foods are designed to meet specific dietary needs for certain diseases.Improvements in symptomatology and regional brain atrophy in AD have been claimed for several medical foods,for example,those providing ketone bodies as alternative energy supply to neurons,those containing precursors believed to improve synaptic function,and those addressing oxidative stress related to memory loss.Many methodological shortcomings render the interpretation of the available findings of medical food trials in AD difficult.Optimal results of medical foods in AD may be expected when administered in presymptomatic or early stages of the disease.This requires the reliable identification of minimal neuropathological changes related to AD.The outcome measures currently used may not be able to detect subtle changes in cognition and function in early AD.Large-scale clinical studies using valid,sensitive,and reliable assessment tools are needed to establish the efficacy of medical foods in AD. | Klaus W.Lange Jianjun Guo Shigehiko Kanaya Katharina M.Lange Yukiko Nakamura Shiming Li | 2019 | Food Science and Human Wellness2019，8，1： | 1 |
| 6 | 钢净化砖CSB显示文摘钢净化砖是由座砖和置于其角部的吹气塞所组成。在不同钢厂的首次试验表明,安装钢净化砖能够起到提高钢水的质量的作用,主要体现在以下几个方面:可以减少由大包带人中间包的下渣;提高汇流区钢水的纯净度(大颗粒夹杂减少);提高产量;减少大包中残余钢水量;使下渣检测系统的功能更加有效;减少水口的堵塞;减少残余料回收,降低了对环境的破坏。 | M.Lange 尹小东 黄宗泽 | 2004 | 世界钢铁2004，4，1： | 0 |
| 7 | Ketogenic diets and Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid-peptide plaques and neurofibrillary tangles.Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD.The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention.This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired.The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD.Both the direct administration of ketone bodies and the use of high-fat,low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients.The mechanism underlying the efficacy of ketogenic diets remains unclear,but some evidence points to the normalization of aberrant energy metabolism.At present there is only limited evidence of the usefulness of ketogenic diets in AD.However,this dietary approach seems to be promising and deserves further clinical investigations. | Klaus W.Lange Katharina M.Lange Ewelina Makulska-Gertruda Yukiko Nakamura Andreas Reissmann Shigehiko Kanaya Joachim Hauser | 2017 | Food Science and Human Wellness2017，6，1： | 0 |
| 8 | Tea and depression显示文摘The available evidence,which derives from studies investigating mechanistic effects of tea,research on animal models as well as epidemiological studies and intervention trials in humans,suggests that compounds contained in tea may have the potential to aid in the prevention of depression or in its treatment as an addition to established therapies.A wide range of potentially antidepressive biological activities of tea components have been reported.However,the mechanisms of tea phytochemicals possibly capable of decreasing the risk of depressive symptoms are complex,multifaceted and not well understood.Potent pharmacological effects on circumscribed neurobiological systems may be produced not by individual tea components but rather by the synergistic action of various compounds on multiple pathophysiological mechanisms involved in depression.While epidemiological studies have generally demonstrated beneficial effects of tea consumption on mood and depressive symptoms,cross-sectional studies are unable to prove a cause-effect relationship.If positive effects on mood could be firmly established,tea drinking could support mental health.However,the moderate antidepressive effects observed in healthy people are not necessarily indicative of possible clinical effects in major depressive disorder.Randomized controlled intervention studies are needed to establish a causal relationship between bioactive compounds in tea and depression. | Klaus W.Lange Yukiko Nakamura Katharina M.Lange Hui Zhao | 2022 | Food Science and Human Wellness2022，11，3： | 0 |
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