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| 1 | 2005--2014年CHINET中国细菌耐药性监测网5种重要临床分离菌的耐药性变迁显示文摘目的收集并分析CHINET中国细菌耐药性监测网中5种重要临床分离菌的耐药性变迁。方法采用纸片扩散法或自动化仪器法按统一方案进行药物敏感性试验。按CLSI 2014年版标准判断结果。结果 2005—2014年,每年的临床分离菌数量为22 774~84 572株。大肠埃希菌中产ESBL菌株检出率为51.7%~55.8%。在上述时期内大肠埃希菌和肺炎克雷伯菌对阿米卡星、环丙沙星、哌拉西林-他唑巴坦和头孢哌酮-舒巴坦的耐药率有所下降。肺炎克雷伯菌中碳青霉烯类耐药株由2.4%上升至13.4%。铜绿假单胞菌对包括亚胺培南和美罗培南的所有受试抗菌药物的耐药率均有所下降。鲍曼不动杆菌对碳青霉烯类的耐药率由31.0%逐步上升至66.7%。耐甲氧西林金黄色葡萄球菌的检出率由2005年的69%逐年下降至2014年的44.6%。结论国内肺炎克雷伯菌和鲍曼不动杆菌对碳青霉烯类的耐药率高。上述结果显示细菌耐药性监测对于细菌感染的有效治疗十分重要。 | f.-p.hu y.guo d.-m.zhu f.wang x.-f.jiang y.-c.xu x.-j.zhang c.-x.zhang p.ji y.xie m.kang c.-q.wang a.-m.wang y.-h.xu j.-l.shen z.-y.sun z.-j.chen y.-x.ni j.-y.sun y.-z.chu s.-f.tian z.-d.hu j.-li y.-s.yu j.lin b.shan y.du y.han s.guo l.-h.wei l.wu h.zhang j.kong y.-j.hu x.-m.ai c.zhuo d.-h.su q.yang b.jia w.huang 胡付品(译) 汪复 | 2017 | 中国感染与化疗杂志2017，17，1： | 419 |
| 2 | 日本的水质标准与水质评价指标显示文摘 | 亀井翼 金兆丰 黄建元 董秉直 M.Kang H.Kim ■田基之 佐藤裕子 真柄泰基 | 2002 | 中国给水排水2002，18，10： | 5 |
| 3 | On the capacity-fairness tradeoff in multiuser diversity systems显示文摘 | L.YANG M.KANG M-S.AILOUINI | | 0，，04： | 1 |
| 4 | The role of extracellular vesicles in acquisition of resistance to therapy in glioblastomas显示文摘Glioblastoma(GBM)is the most aggressive primary brain tumor with a median survival of 15 months despite standard care therapy consisting of maximal surgical debulking,followed by radiation therapy with concurrent and adjuvant temozolomide treatment.The natural history of GBM is characterized by inevitable recurrence with patients dying from increasingly resistant tumor regrowth after therapy.Several mechanisms including inter-and intratumoral heterogeneity,the evolution of therapy-resistant clonal subpopulations,reacquisition of stemness in glioblastoma stem cells,multiple drug efflux mechanisms,the tumor-promoting microenvironment,metabolic adaptations,and enhanced repair of drug-induced DNA damage have been implicated in therapy failure.Extracellular vesicles(EVs)have emerged as crucial mediators in the maintenance and establishment of GBM.Multiple seminal studies have uncovered the multi-dynamic role of EVs in the acquisition of drug resistance.Mechanisms include EV-mediated cargo transfer and EVs functioning as drug efflux channels and decoys for antibody-based therapies.In this review,we discuss the various mechanisms of therapy resistance in GBM,highlighting the emerging role of EV-orchestrated drug resistance.Understanding the landscape of GBM resistance is critical in devising novel therapeutic approaches to fight this deadly disease. | Anudeep Yekula Abigail Taylor Alexandra Beecroft Keiko M.Kang Julia L.Small Koushik Muralidharan Zachary Rosh Bob S.Carter Leonora Balaj | 2021 | Cancer Drug Resistance2021，4，1： | 0 |
| 5 | 气溶胶分布演变所引发的气候响应模态显示文摘人类活动起源的气溶胶主要分布在北半球,其引发的区域气候响应特征及动力机理仍不清楚.针对这个问题设计的理想化数值试验的结果表明,气溶胶引起的气候变化分为两个阶段:1940~1980年,全球气溶胶增多,引发向北半球输运能量的纬向平均气候响应模态;1980~2020年,气溶胶强迫从西半球向东半球纬向迁移,海盆尺度的海洋-大气耦合过程变得重要,气候响应在太平洋和大西洋间呈现显著的差异.海洋动力过程会减弱纬向平均模态但加强纬向变化模态,特别是太平洋的响应在这两个阶段均呈现拉尼娜型的海温异常分布.本文揭示了气溶胶强迫引发的两个气候响应模态的差异,有利于对历史气候变化的认识和归因. | Sarah M.Kang 谢尚平 Clara Deser 向宝强 | 2021 | Science Bulletin2021，66，23： | 0 |
| 6 | Ki—67、P_(53)及Bcl—2在结肠锯齿状腺瘤中的表达显示文摘良性结直肠上皮性息肉传统上被分为两种类型:增生性息肉和腺瘤。前者具柱状吸收细胞增多形成微乳头突入腺隐窝腔中使腔面呈锯齿状及肿胀的杯状细胞的特点,被认为不具有形成肿瘤的潜能。后者具腺腔呈指状、核深染、细胞排列成多层的特点,被认为是结肠癌的先兆。除此之外,在一种息肉具有以下特征:腺腔呈锯齿状、杯状细胞发育不全、腺隐窝上部核分裂像多见,上皮细胞内可见核仁,它既具有增生性息肉的特点结构又具有腺瘤的细胞学特征,这种混合性息肉是结肠直上皮性肿瘤的一种特殊亚型,称为锯齿状腺瘤。本研究比较这三种息肉Ki—67、P_(53)及Bcl—2的表达情况。 | M.Kang H.Mitomi M.Sada 镇鸿燕 | 1998 | 武汉职工医学院学报1998，26，4： | 0 |
| 7 | Generalized Anxiety and Major Depressive Symptoms of General Public in South Korea during the Early COVID-19 Pandemic显示文摘The extent of viral spread and strategies in dealing with the COVID-19 pandemic have been different in each country.There are overall increased mental health concerns in many countries but it is unclear what the general public individuals who do not have heighten vulnerability to stressors for existing mental diseases or significant physical illnesses were experiencing during the pandemic.We evaluated the stressors and mental health of general public in South Korea that has a relatively low confirmed cases and deaths.Responses on the on-line survey questions were used to assess the mental and physical symptoms in association with individuals’reported stressors.Individuals with the symptoms of the generalized anxiety disorder(GAD)were reported in 58.9%,and major depression(MD)in 23.2%,mostly in minimal to mild degrees,cut-off scores of 5 and 10,respectively by the validated screening tools,GAD-7 and PHQ-9.Both GAD and MD symptoms were in 21.5%of the respondents.The total number of stress had significant association with the scores of GAD-7,PHQ-9,physical symptoms,sleep difficulties and resilience(p<0.01).GAD scores were also associated with sleep difficulties(p<0.01)and raising young children(p<0.05).MD scores were associated with sleep difficulties,job-dissatisfaction,and educational level(p<0.05).The limitations of the study include small sample size,usage of smartphone or email,potential under-reporting by stigma in the socio-cultural context and evolving nature of pandemic.We conclude that keeping careful watch for mental symptoms,stressors,sleep difficulties and other physical symptoms are important even for the individuals without previous mental illnesses during the pandemic era. | Kye S.Kim Peter M.Kang He Sook N.Kim | 2021 | International Journal of Mental Health Promotion2021，23，3： | 0 |
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