| 1 | Genetic variation in the chemokine receptor 5 gene and course of HIV infection;review on genetics and immunological aspect显示文摘Chemokines are small protein molecules associated with various physiological events precisely in immune modulation via dhemokine receptors.The chemokine receptors are G-protein coupled receptors express mainly on the cell surface of immune cells.Retrovi-ruses,including HIV in the early stage of infection,primarily target chemokines receptors and get intemalized easily into immune cells;T cell and escape from immune surveillance.HIV glycoprotein selectively develops an affinity for the extracellular domain of chemokines recep-tors and allows the pathogen to intemalize via CCR-5.Now,CCR-5 remains a crucial signaling pathway that can be translated into the therapeutic target by changing the receptor protein environment.Many populations have a mutation in coding and promoter regions of CCR-5,tun-ing a resistance for HIV infection.Natively,there are several mechanisms where the human genome remains in the dynamic state by changing its composition and acquiring variations.Sin-gle nucleotide polymorphism is spontaneous phenomenon responsible for precise and point mutation at the genome.Several studies have demonstrated that European and African Amer-ican populations are enriched in significant CCR5 promoter SNP(CCR5432)in the coding and promoter region as well.Now,such SNP can be an early-stage biomarker in studying HIV and other similar infections.Here,in this study,we have elucidated the role of SNP(both the pro-moter and coding region)and the fate of HIV infections.We also empathized with the genetics of such SNPs,mostly frequency and its immunological impact. | M.K.Verma S.Shakya | 2021 | Genes & Diseases2021，8，4： | 0 |
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