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| 1 | MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review显示文摘 | Marilena V.Iorio Carlo M.Croce | 2012 | EMBO Mol Med2012，，3： | 3 |
| 2 | MicroRNAs in cancer: personalizing diagnosis and therapy显示文摘 | S. PatrickNana‐Sinkam MullerFabbri Carlo M.Croce | 2010 | Annals of the New York Academy of Sciences2010，，1： | 1 |
| 3 | MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review显示文摘 | Marilena V.Iorio Carlo M.Croce | 2012 | EMBO Mol Med2012，，3： | 1 |
| 4 | MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review显示文摘 | Marilena V.Iorio Carlo M.Croce | 2012 | EMBO Mol Med2012，，3： | 1 |
| 5 | Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance显示文摘Non-small cell lung cancer(NSCLC)is the leading cause of cancer-related mortality worldwide.Platinum-based chemotherapy represents the main treatment,despite about the 70%of tumors are intrinsically resistant.Deciphering the mechanisms of platinum-resistance is urgently needed. | Gian Luca Rampioni Vinciguerra Marina Capece Rosario Distefano Giovanni Nigita Andrea Vecchione Francesca Lovat Carlo M.Croce | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 6 | PDCD1(PD-1)is a direct target of miR-15a-5p and miR-16-5p显示文摘Dear Editor,Programmed cell death protein 1(PD-1;encoded by the PDCD1 gene),mostly expressed on activated T cells,is an important receptor in T-cell immunity.1–3 Together with programmed deathligand 1(PD-L1:encoded by the CD274 gene)PD-1 acts as an inhibitor of T cell activity under normal conditions. | Alexey Palamarchuk Liudmyla Tsyba Luisa Tomasello Yuri Pekarsky Carlo M.Croce | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 7 | Pleiotropic tumor suppressor functions of WWOX antagonize metastasis显示文摘Tumor progression and metastasis are the major causes of death among cancer associated mortality.Metastatic cells acquire features of migration and invasion and usually undergo epithelia-mesenchymal transition(EMT).Acquirement of these various hallmarks rely on different cellular pathways,including TGF-βand Wnt signaling.Recently,we reported that WW domain-containing oxidoreductase(WWOX)acts as a tumor suppressor and has anti-metastatic activities involving regulation of several key microRNAs(miRNAs)in triple-negative breast cancer(TNBC).Here,we report that WWOX restoration in highly metastatic MDA-MB435S cancer cells alters mRNA expression profiles;further,WWOX interacts with various proteins to exert its tumor suppressor function.Careful alignment and analysis of gene and miRNA expression in these cells revealed profound changes in cellular pathways mediating adhesion,invasion and motility.We further demonstrate that WWOX,through regulation of miR-146a levels,regulates SMAD3,which is a member of the TGF-βsignaling pathway.Moreover,proteomic analysis of WWOX partners revealed regulation of the Wnt-signaling activation through physical interaction with Disheveled.Altogether,these findings underscore a significant role for WWOX in antagonizing metastasis,further highlighting its role and therapeutic potential in suppressing tumor progression. | Saleh Khawaled Giovanni Nigita Rosario Distefano Sara Oster Sung-Suk Suh Yoav Smith Abed Khalaileh Yong Peng Carlo M.Croce Tamar Geiger Victoria L.Seewaldt Rami I.Aqeilan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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