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| 1 | Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression显示文摘AIM: To understand the role of mitochondrial-produced superoxide(O 2 ?) in the regulation of iron-regulatory hormone, hepcidin by alcohol in the liver. METHODS: For alcohol experiments, manganese superoxide dismutase knockout mice heterozygous for Sod2 gene expression(Sod2 +/) and age-matched littermate control mice(LMC), expressing Sod2 gene on both alleles, were exposed to either 10%(w/v) ethanol in the drinking water or plain water(control) for 7 d. Total cellular O 2 ? levels in hepatocytes isolated from the livers of mice were measured by electron paramagnetic resonance spectroscopy. The mitochondrial-targeted, O 2 ?-sensitive fluorogenic probe, MitoSOX Red and flow cytometry were utilized to measure O 2 ? in mitochondria. Gene and protein expression were determined by Taqman Real-time quantitative PCR and Western blotting, respectively. RESULTS: Sod2 +/- mice expressed 40% less MnSOD protein(SOD2) in hepatocytes compared to LMC mice. The deletion of Sod2 allele did not alter the basal expression level of hepcidin in the liver. 10% ethanol exposure for 1 wk inhibited hepatic hepcidin mRNA expression three-fold both in Sod2 +/ and LMC mice. O 2 ? levels in hepatocytes of untreated Sod2 +/ mice were three-fold higher than in untreated LMC mice, as observed by electron paramagnetic resonance spectroscopy. O 2 ? levels in mitochondria of Sod2 +/ mice were four-fold higher than in mitochondria of untreated LMC mice, as measured by MitoSOX Red fluorescence and flow cytometry. Alcohol induced a two-fold higher increase in O 2 ? levels in hepatocytes of LMC mice than in Sod2 +/ mice compared to respective untreated counterparts. In contrast, 1 wk alcohol exposure did not alter mitochondrial O 2 ? levels in both Sod2 +/- and control mice. CONCLUSION: Mitochondrial O2 ? is not involved in the inhibition of liver hepcidin transcription and thereby regulation of iron metabolism by alcohol. These findings also suggest that short-term alcohol consumption significantly elevates O 2 ? levels in hepatocytes, which appears not to originate from mitochondria. | Duygu Dee Harrison-Findik Sizhao Lu Emily M Zmijewski Jocelyn Jones Matthew C Zimmerman | 2013 | World Journal of Biological Chemistry2013，4，4： | 2 |
| 2 | Some Economic Determinants of Accounting Policy Choice显示文摘 | HAGERMAN R L ZMIJEWSKI M E | 1979 | Journal of Account- ing and Economics1979，1，2： | 1 |
| 3 | Methodological issues related to the estimation of financial distress frediction model显示文摘 | Zmijewski M E | 1984 | Journal of Accounting Research1984，，： | 1 |
| 4 | An income strategy approach to the positive theory of accounting standard setting and choice显示文摘 | ZMIJEWSKI M HAGERMAN R | 1981 | Journal of Accounting and Economics1981，，3： | 1 |
| 5 | Methodological issues related to the estimation of financial distress prediction models显示文摘 | Zmijewski M E | 1984 | Journal of Accounting Research (Supplement)1984，，： | 1 |
| 6 | Cross-Sectional Variation in the Stock Market Response to Accounting Earnings Announcements显示文摘 | Easton P D Zmijewski M E | 1991 | Journal of Accounting and Economics1991，7，： | 1 |
| 7 | The relative informativeness of accounting disclosures in different countries 显示文摘 | Alford A J Jones R Leftwich M Zmijewski | 1993 | Journal of Accounting Research1993，31，： | 1 |
| 8 | Methodological Issues Related to the Estimation of Financial Distress Prediction Models显示文摘 | Zmijewski M | 1984 | Journal of Accounting Research1984，，： | 1 |
| 9 | Some economic determinants of accounting policy choice显示文摘 | HAGERMAN R ZMIJEWSKI M | 1979 | Journal of Accounting and Economics1979，1，2： | 1 |
| 10 | Security Analyst Superiority Relative to Univariate Time-Series Models in Forecasting Quarterly Earnings 显示文摘 | Brown L D R L Hagerman P A Griffin M E Zmijewski | 1987 | Journal of Account- ing and Economics1987，，9： | 1 |
| 11 | Cross-Sectional Variation in the Stock Market Response to Accounting Earnings Announcements显示文摘 | Easton P D Zmijewski M E | 1989 | Journal of Account- iag and Economics1989，11，2： | 1 |
| 12 | On the role of melatonin in skin physiology and pathology 显示文摘 | Slominski A Fischer T W Zmijewski M A | 2005 | Endocrine2005，27，： | 1 |
| 13 | Oncostatic efeects of the indole melatonin and ex- pression of its cytoslic and nuclear receptor in culture human cell line 显示文摘 | FISCHER T W ZMIJEWSKI M A ZBYTEK B | 2006 | Int J Oncol2006，29，3： | 1 |
| 14 | Methodological issues related to the estimation of financial distress prediction models显示文摘 | ZMIJEWSKI M E | 1984 | Studies on Current Econometric Issues in Accounting Research1984，22，9： | 1 |
| 15 | Methodological issues related to the estimation of financial distress prediction models 显示文摘 | ZMIJEWSKI M E | 1950 | Journal of Accounting Research1950，22，： | 1 |
| 16 | Cross - Sectional Variation in the Stock Market Responcs to Accounting Earnings Announcements 显示文摘 | Easton P Zmijewski M | 1989 | Journal of Accounting and Economics1989，，11： | 1 |
| 17 | Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines显示文摘 | Fischer T W Zmijewski M A Zbytek B | 2006 | Int J Oncol2006，29，3： | 1 |
| 18 | Methodological Issues Related to the Estimation of Financial Distress Prediction Models 显示文摘 | Zmijewski M E | 1984 | Journal of Accounting Research1984，，22： | 1 |
| 19 | Methodological issues related to the estimated of financial distress prediction models 显示文摘 | Zmijewski M E | 1984 | Journal of Accounting Research1984，22，1： | 1 |
| 20 | An income strategy approach to the positive theory of accounting standard setting and choice 显示文摘 | Zmijewski M Hagerman R | 1981 | Journal of Accounting and Economics1981，，3： | 1 |
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