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| 1 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 2 | Treatment of urethral diseases with Neodymium- YAG laser显示文摘 | Bloiso G Warner R Cohen M | 1988 | J Uro11988，32，： | 2 |
| 3 | Chlorofluoromethans in South Atlantic antarctic intermediate water显示文摘 | WARNER M J WEISS R F | 1992 | Deep-Sea Res1992，39，： | 2 |
| 4 | Spectroscopic study of the interaction of catechin with α, β, and γ/-cyclodextrins 显示文摘 | Smith Vonda K Ndou Thilivhali T Warner Isiah M | 1994 | J Phys Chem1994，98，： | 1 |
| 5 | Activity of chequerboard combinations of ceftaroline and NXL104 versus β-lactamase-producing Enterobacteriaceae显示文摘 | Mushtaq S Warner M Williams G | 2010 | J Antimicrob Chemother2010，65，7： | 1 |
| 6 | Identification of novel Smad binding proteins 显示文摘 | Warner D R Roberts E A Greene R M | 2003 | Biochem Biophys Res Commun2003，312，4： | 1 |
| 7 | Effect of graded doses of ionizing radiation on the human testis显示文摘 | Rowley M J Leach DR Warner GA | 1974 | Radiat Res1974，59，3： | 1 |
| 8 | Estrogen receptor beta in the prostate显示文摘 | Z WEIHUA M WARNER JA GUSTAFSSON | 2002 | Mol Cell Endocrinol2002，19，3： | 1 |
| 9 | Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters 显示文摘 | Mushtaq S Warner M Livermore D | 2010 | J Antimicrob Chemother2010，65，： | 1 |
| 10 | A finite-element linked model for analysis of solute transport in3D space of multilayer subsurface systems 显示文摘 | Ghulam Rabbani M Warner James W | 1997 | Journal of Hydrology1997，199，： | 1 |
| 11 | Estrogen receptor expression inthe embryonic brain regulates development of calretinin-immunore-active GABAergic interneurons显示文摘 | Fan X Warner M Gustafsson JA | 2006 | Proc Natl Acad Sci USA2006，103，19： | 1 |
| 12 | Maternal Serum Dioxin Levels and Birth Outcomes in Women of Seveso,Italy显示文摘 | Eskenazi B Mocarelli P Warner M | 2003 | Enviromental Health Perspectives2003，111，： | 1 |
| 13 | Condom effectiveness for prevention of trachoma infection显示文摘 | Warner L Macaluso M Newman D | 2006 | Sexually transmitted infections2006，82，3： | 1 |
| 14 | Lifetime cooecurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the national comorbidity survey 显示文摘 | Kessler R C Crum R M Warner L A | 1997 | Archives of General Psychiatry1997，54，： | 1 |
| 15 | Vitamin Aantagonizes decreased cell growth and elevated collagen-de-grading matrix metalloproteinases and stimulates collagen ac-cumulation in naturally aged human skin显示文摘 | Varani J Warner RL Gharaee-Kermani M | 2000 | J Invest Der-matol2000，114，3： | 1 |
| 16 | Epidemiology of anesthesia-relat- ed mortality in the United States, 1999 - 2005 显示文摘 | Li G Warner M Lang BH | 2009 | Anesthesiology2009，110，4： | 1 |
| 17 | In vitro activity of ceftazi- dimelNXL104 against Psendomonas aeruginosa and other non - fermenters显示文摘 | Mushtaq S Warner M Livermore DM | 2010 | J Antimicrob Chemother2010，65，11： | 1 |
| 18 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 19 | The curse of natural resources 显示文摘 | Sachs J D Warner A M | 2001 | European economic review2001，45，4： | 1 |
| 20 | Trends in regional inequality in China显示文摘 | Jian T Sachs J D Warner A M | 1996 | China Economic Review1996，7，1： | 1 |
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