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| 1 | Role of laryngeal mask airway in laparoscopic cholecystectomy显示文摘Laparoscopic cholecystectomy is one of the most commonly performed surgical procedures and the laryngeal mask airway(LMA) is the most common supraglottic airway device used by the anesthesiologists to manage airway during general anesthesia. Use of LMA has some advantages when compared to endotracheal intubation, such as quick and ease of placement, a lesser requirement for neuromuscular blockade and a lower incidence of postoperative morbididy. However, the use of the LMA in laparoscopy is controversial, based on a concern about increased risk of regurgitation and pulmonary aspiration. The ability of these devices to provide optimal ventilation during laparoscopic procedures has been also questioned. The most important parameter to secure an adequate ventilation and oxygenation for the LMA under pneumoperitoneum condition is its seal pressure of airway. A good sealing pressure, not only state correct patient ventilation, but it reduces the potential risk of aspiration due to the better seal of airway. In addition, the LMAs incorporating a gastric access, permitting a safe anesthesia based on these commented points. We did a literature search to clarify if the use of LMA in preference to intubation provides inadequate ventilation or increase the risk of aspiration in patients undergoing laparoscopic cholecystectomy. We found evidence stating that LMA with drain channel achieves adequate ventilation for these procedures. Limited evidence was found to consider these devices completely safe against aspiration. However, we observed that the incidence of regurgitation and aspiration associated with the use of the LMA in laparoscopic surgery is very low. | José M Belena Ernesto Josué Ochoa Mónica Núnez Carlos Gilsanz Alfonso Vidal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 4 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 4 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 5 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 6 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 7 | Determination of multiclass pesticides in food commodities by pressurized liquid extraction using GC-MS/MS and LC-MS/MS 显示文摘 | Frenich A G Salvador I M Vidal J L M Lopez T L | 2005 | Analytical and Bioanalytical Chemistry2005，33，78： | 1 |
| 8 | Early postoperative arterial oxygen desaturation显示文摘 | Canet J Ricos M Vidal F | 1989 | Anesth Analg1989，69，2： | 1 |
| 9 | Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry显示文摘 | VIDAL J L M FRENICH A G AGUILERA-LUIZ M M | 2010 | Analytical and Bioanalytical Chemistry2010，397，7： | 1 |
| 10 | Identification and characterization of a second mouse Nramp gene 显示文摘 | Gruenheid S Cellier M Vidal S | 1995 | Ge- nomics1995，25，2： | 1 |
| 11 | Studying the effects of laccase-catalysed grafting of ferulic acid on sisal pulp fibers显示文摘 | Aracri E Roncero M B Vidal T | 2011 | Bioresource Technology2011，102，： | 1 |
| 12 | Identification of Hake species (Merluccius Genus) using sequencing and PCR-RFLP analysis of mitochondrial DNA con- trol region sequences显示文摘 | Quinteiro J Vidal R Izquierdo M | 2001 | J Agric Food Chem2001，49，11： | 1 |
| 13 | Bowel dysfunction in patients with motor complete spinal cord injury: clinical, neurological, and pathophysiological associations显示文摘 | Valles M Vidal J Clave P | 2006 | Am J Gastroenterol2006，101，10： | 1 |
| 14 | Linear transceiver design in nonregenerative relays with channel state information显示文摘 | Medina O M Vidal J Agustin A | 2007 | IEEE Trans on Signal Processing2007，55，6： | 1 |
| 15 | The LuxS- dependent quorum sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39显示文摘 | Vidal J E Ludewick H P Kunkel R M | 2011 | Infect Immun2011，79，10： | 1 |
| 16 | Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs 显示文摘 | Vidal O Varona L Oliver M A | 2005 | Anim Genet2005，37，： | 1 |
| 17 | Laparoendoscopic single-site cholecystectomy:A safe and reproducible alternative显示文摘 | Vidal O Valentini M Espert JJ | 2009 | Japarown- dosc Adv Surg TechA2009，19，5： | 1 |
| 18 | Chemical force titration of plasma polymer - modified PDMS substrates by using plasma polymer- modified AFM tips显示文摘 | Geissler A Vallat M F Vidal L | 2008 | Langmuir2008，24，： | 1 |
| 19 | Compartment syndromefollowing intraosseous infusion 显示文摘 | Vidal R Kissoon N Gayle M | 1993 | Pediatrics1993，91，6： | 1 |
| 20 | Copy number variation in the genomes of domestic animals显示文摘 | Clop A Vidal O Amills M | 2012 | Anim Genet2012，43，5： | 1 |
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