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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Atomic decomposition by basis pursuit显示文摘 | CHEN S B DONOHO D L SAUNDERS M A | | 0，，01： | 2 |
| 3 | Downsizing,delayering-but where is the commitment? The development of a diagnostic tool to help management survivors显示文摘 | THORNHILL A SAUNDERS M N K STEAD J | 1997 | Personnel Review1997，26，12： | 1 |
| 4 | Rice Bran Protein Concentrates by Wet Alkaline Extraction显示文摘 | Conner M Saunders R M Kohler G O | 1973 | Cereal Chemistry1973，，53： | 1 |
| 5 | Identification and comparison of aerobic and denitrifying polyphosphateaccumulating organisms显示文摘 | Zeng R J Saunders A M Yuan Z G | 2003 | Biotechnol Bioeng2003，83，2： | 1 |
| 6 | Effect of lake trophic status and rooted macrophytes on community composition and abundance of ammonia-oxidizing prokaryotes in freshwater sediments显示文摘 | Herrmann M Saunders A M Schramm A | 2009 | Appl Environ Microbiol2009，75，10： | 1 |
| 7 | A randomised multicentre trial显示文摘 | Saunders M Dische S Barrett A et aL Continuous hyperfractionaed accelerated radiotherapy(CHART)versus conventional radiotherapy in non-small-cell lung cancer | 1997 | Lancet1997，350，9072： | 1 |
| 8 | Effect of growth hormone administration and dietary protein intake on insulin-like growth factor I and growth hormone receptor mRNA expression in porcine liver, skeletal muscle, and adipose tissue显示文摘 | Brameld J M Alkinson J L Saunders J C | | J Anim0，，： | 1 |
| 9 | Typing of Listeria monocytogenes for epidemiological studies using DNA probes显示文摘 | SAUNDERS N A RIDLEY A M TAYLOR A G | 1989 | Acta Microbiol Hung1989，，36： | 1 |
| 10 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 11 | Atomic decomposi- tion by basis pursuit 显示文摘 | Chen S S Donoho D L Saunders M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 12 | Identification and comparison of aerobic and denitrifying organisms显示文摘 | Raymond J Zeng Aaron M Saunders Zhiguo Yuan | 2003 | Biotechnology and Bioengineering2003，83，2： | 1 |
| 13 | Use and impact of satellite atmospheric motion winds on ECMWF analyses and forecasts显示文摘 | Tomassini M Kelly G Saunders R | 1999 | Monthly Weather Review1999，127，6： | 1 |
| 14 | A study of circulationstatistics of books on demand: a decade of patron-driven collection development, part 3显示文摘 | Nixon J M Saunders E S | 2010 | CollectionManagement2010，35，34： | 1 |
| 15 | Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model 显示文摘 | Amu S Saunders SP Kronenberg M | 2010 | J Allergy Clin Immunol2010，125，： | 1 |
| 16 | Identification of phosphate-reactive sites of hydrous alumina from proton consumption during phosphate adsorption at constant pH values显示文摘 | Rajan S S S Perott K w Saunders W M H 1974 | 1974 | J Soil Sci1974，25，： | 1 |
| 17 | Atomic Decomposition by Basis Pursuit 显示文摘 | Chen S Donoho D Saunders M | 1999 | SIAM Jounal on Scientific Computing1999，20，： | 1 |
| 18 | Preheating and controlled thermal cycling of steel handling ladles显示文摘 | Saunders L M | 1983 | Steelmaking Proceeding1983，66，： | 1 |
| 19 | Assessing pho tochemieal ozone ormation in the Pearl River Delta with a photochemical trajectory model显示文摘 | CHENG H R GUO H SAUNDERS S M | 2010 | Atmospheric Environment2010，44，34： | 1 |
| 20 | Regulatory B cells prevent and reverse allergic airway inflammation via Foxp3 posi tire T regulatory cells in a murine model 显示文摘 | Amu S Saunders SP Kronenberg M | 2010 | J Allergy Clin Im munol2010，125，5： | 1 |
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