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| 1 | Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab显示文摘AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease.METHODS:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin C);(2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer(TRACC) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre(NSWCC) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin C).In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal metastases.Secondary endpoints included progression-free survival,chemotherapy duration,and overall survival.Time-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS:Eighty-four MAX,179 TRACC and 69 NSWCC patients had peritoneal disease.There were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC cohorts.Of the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone arm.In the TRACC registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone arm.In a further analysis of patients without peritoneal metastases in the TRACC registry,the rate of gastrointestinal perforations was 9/369(2.4%) in the chemotherapy/bevacizumab group and 5/177(2.8%) in the chemotherapy alone group.The addition of bevacizumab to chemotherapy was associated with improved progression-free survival in all three cohorts:MAX 6.9 m vs 4.9 m,HR = 0.64(95%CI:0.42-1.02);P = 0.063;TRACC 9.1 m vs 5.5 m,HR = 0.61(95%CI:0.37-0.86);P = 0.009;NSWCC 8.7 m vs 6.8 m,HR = 0.75(95%CI:0.43-1.32);P = 0.32.Chemotherapy duration was similar across the groups.CONCLUSION:Patients with peritoneal disease do not appear to have an increased risk of gastrointestinal perforations when receiving first-line therapy with bevacizumab compared to systemic therapy alone. | Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran Jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott Val Gebski Weng Ng Wei Chua Timothy Price Niall Tebbutt Lorraine Chantrill | 2015 | World Journal of Gastroenterology2015，21，17： | 3 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Feasibility of percutaneous transluminal angioplasty for carotid artery stenosis显示文摘 | Brown M M Butler P Gibbs J | 1990 | J Neurol Neurosurg Psychiatry1990，53，3： | 2 |
| 4 | Vibration energy transmission and mode conversion at a corner junction of square section rods显示文摘 | Gibbs B M Tattersall J D | 1987 | J Vib Acoust Stress Rel Dsgn1987，109，： | 2 |
| 5 | Long-term aeration management for improved N-removal via SND in a sequencing batch reactor显示文摘 | THIRD K A GIBBS B NEWLAND M | 2005 | Water Research2005，39，： | 1 |
| 6 | Influence of chitosan preprotonation on reactive black 5 sorption isotherms and kinetics 显示文摘 | GIBBS G JOHN M | 2004 | Ind Eng Chem Rcs2004，43，： | 1 |
| 7 | Variational Gaussian process classifiers显示文摘 | GIBBS M N MACKAY D J C | 2000 | IEEE Transactions on Neural Net- works2000，11，6： | 1 |
| 8 | Reference sce- narios for deforestation and forest degradation in support of REDD : a review of data and methods 显示文摘 | Olander P Gibbs H K Steininger M | 2008 | Environmental Re- search Letters2008，，02： | 1 |
| 9 | Control of com bustion-generated nitrogen oxides by selective non-cata- lytic reduction 显示文摘 | JAVED M T IRFAN N GIBBS B M | 2007 | Journal of Environmental Management2007，83，3： | 1 |
| 10 | Diffusion changes precede size reduction in neoadjuvant treatment of breast cancer显示文摘 | Pickles MD Gibbs P Lowry M | 2006 | Magn Reson Imaging2006，24，7： | 1 |
| 11 | Raman spectroscopic library of natural and synthetic pigments (pre-- 1850 AD)显示文摘 | Bell I M Clark R J H Gibbs P J | 1997 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy1997，53，12： | 1 |
| 12 | Raman spectroscopic library of natural and synthetic pigments (pre- 1850AD) 显示文摘 | Bell I M Clark R J H Gibbs P J | 1997 | Spectrochim Acta Part A: Mol Biomol Spectr1997，53，12： | 1 |
| 13 | Pathogenesis of experi- mental Ebola Zaire virus infection in BALB/c mice显示文摘 | Gibb TR Bray M Geisbert TW | 2001 | J Comp Pathol2001，125，4： | 1 |
| 14 | Insights into social insects from the genome of the honeybee Apis mellifera 显示文摘 | WEINSTOCK G M ROBINSON G E GIBBS R A | 2006 | Nature2006，443，： | 1 |
| 15 | Localization of phycoerythrin at the lumennal surface of the thylakoid membrance in Rhodo- monas lens 显示文摘 | Ludwig M Gibbs S P | 1989 | The Journal of Cell Biology1989，108，： | 1 |
| 16 | Impact of air staging on the fate of NO and N2O in a circulating fluidized-bed combustor 显示文摘 | Wang X S Gibbs B M Rhodes M J | 1994 | Combustion and Flame1994，99，34： | 1 |
| 17 | Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction - and phesphatidylinesitol-3-kinase-independent pathway 显示文摘 | Etgen G J Jr Fryburg D A Gibbs E M | 1997 | Diabetes1997，46，： | 1 |
| 18 | Genetic analysis of four porcine avian influenza viruses isolated from Shandong 显示文摘 | Shi W F Gibbs M J Zhang Y Z | 2008 | China Arch Virol2008，153，： | 1 |
| 19 | Experimental and modeling study of the effect of CO and H2 on the urea DeNOx process in a 150kW laboratory reactor显示文摘 | Javed M T Nirnmo W Gibbs B M | 2008 | Chemosphere2008，70，6： | 1 |
| 20 | Calcium-based sorbents for simultaneous NOx/SOx reduction in a down-fired furnace显示文摘 | Patsias A A Nimmo W Gibbs B M | 2005 | Fuel2005，84，1415： | 1 |
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