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| 1 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | Critical switching impulse breakdown of long bundle-coductor gaps显示文摘 | Farouk A M Rizk | 1996 | IEEE Transactions on Power Delivery1996，11，1： | 1 |
| 3 | Critical switching impulse breakdown of long bundle-coductor gaps显示文摘 | Farouk A M Rizk | 1996 | IEEE Transactions on Power Delivery1996，11，1： | 1 |
| 4 | Effect of diet and fat content on the func- tional properties of thawed beef显示文摘 | FAROUK M WIELICAKO K | 2003 | Meat Science2003，64，4： | 1 |
| 5 | Modeling of the air plasma near the tip of the positive leader显示文摘 | Vidal F Gallimberti I Farouk A M | 2002 | IEEE Trans on Plasma Science2002，30，3： | 1 |
| 6 | Meta-analysis of randomized eontrolled trials on the safety and effectiveness of day-case laparo- scopic cholecystectomy显示文摘 | Gurusamy K Junnarkar S Farouk M | 2008 | Br J Surg2008，95，2： | 1 |
| 7 | Modeling of altitude effects on AC flashover of polluted high voltage insulators显示文摘 | Farouk A M Rezazada A Q | 1997 | IEEE Transaetion on Power Delivery1997，12，2： | 1 |
| 8 | Small heat shock proteins and their role in meat tenderness: a review显示文摘 | LOMIWES D FAROUK M M WIKLUND E | 2014 | Meat Science2014，96，1： | 1 |
| 9 | Labeling of atenolol with radioactive iodine-125 using N-bromosuccinimide and hydrogen peroxide as oxidizing agents显示文摘 | El-Tawoosy M Farouk N El-Bayoumy AS | | 0，，3： | 1 |
| 10 | Cooked sausage batter cohesiveness as affected by sarcoplasmic proteins 显示文摘 | Farouk M M Wieliczko K Lira R | 2002 | MeatScience2002，61，1： | 1 |
| 11 | UK guidelines for the management of acute pancreatitis 显示文摘 | Gurusamy KS Farouk M Tweedie JH | 2005 | Gut2005，54，3： | 1 |
| 12 | Preoperative concomitant radiotherapy with oral capecitsbine in advanced rectal cancer within 6cm from anal verge 显示文摘 | Elshazly WG Farouk M Samy M | 2009 | Int J Colorectal Dis2009，24，40： | 1 |
| 13 | UK guidelines for the mangement of acute panceatitis 显示文摘 | Gurusamy K S Farouk M Tweedie J H | 2005 | Gut2005，54，3： | 1 |
| 14 | Ultra-fast freezing and low storage temperatures are not necessary to maintain the functional properties of manufacturing beef显示文摘 | FAROUK M M WIELICZKO K J MERTS I | 2004 | MeatScience2004，66，1： | 1 |
| 15 | De- sign of a Piolot Plant for complete processing of by-Products of the tanning industry 显示文摘 | Farouk M M Price J F Salih A M | 1990 | Food Science1990，556，： | 1 |
| 16 | Small heat shock proteins and toughness in intermediate pHu beef显示文摘 | LOMIWES D FAROUK M M FROST D A | 2013 | Meat Science2013，95，3： | 1 |
| 17 | Indications for and tech- niques of local resection of tumors of the papilla of rater显示文摘 | Farouk M Niostis M Branum GD | 1991 | Arch Surg1991，126，5： | 1 |
| 18 | Small heat shock proteins and their role in meat tenderness: a review显示文摘 | LOMIWES D FAROUK M M WIKLUND E | 2013 | Meat Science2013，96，： | 1 |
| 19 | The 'sponge effect' hypothesis: an alternative sociated proteins: the third myofilament system of the scarcomere显示文摘 | FAROUK M M WU G KRSINIC G | 2005 | Advances in Protein Chemistry2005，71，： | 1 |
| 20 | Phytate - de- grading enzyme production by bacteria isolated from Malaysian soil 显示文摘 | Hussin A S M Farouk A E Greiner R | 2007 | World Journal of Microbiology anti Biotechnology2007，23，12： | 1 |
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