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| 1 | Diagnosis and surgical management of breast cancer metastatic to the spine显示文摘Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompres-sion and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. | Derek G Ju Alp Yurter Ziya L Gokaslan Daniel M Sciubba | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 2 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 3 | Infection con- troll practice in countries with bruited resources显示文摘 | ALP E LEBLEBICIOGLU H DOGANAY M | 2011 | Ann Clin Mi- crobiol Antimicrob2011，10，1： | 1 |
| 4 | Effects of dietary probiotic and prebiotic supplementation on growth performance and serum Ig G concentration of broilers显示文摘 | Midilli M Alp M Kocabagh N | 2008 | South African Journal of Animal Science2008，37，： | 1 |
| 5 | The effects of the novel anti-anginal RS43285 on, and pH in a canine model of transient my ocardial ischaemia显示文摘 | ALLEY M C ALPS B J N KILPATRICK A T | 1987 | Biochem Soc Trans1987，15，6： | 1 |
| 6 | A modified yoga-based exercise program in hemodialysis patients: a randomized controlled study显示文摘 | Yurtkuran M Alp A Yurtkuran M | 2007 | Complement Ther Med2007，15，3： | 1 |
| 7 | Current therapeutic strategy in spinal brucellosis显示文摘 | Alp E Doganay M | 2008 | Infect Dis2008，，12： | 1 |
| 8 | Multidisciplinay treatment of posterior circulation ischemia显示文摘 | Alp MS Hier D | 2004 | Neurol Res2004，26，： | 1 |
| 9 | The effects of dietary oregano essential oil on live performance,carcass yield,serum immunoglobulin G level,and oocyst count in broilers显示文摘 | M Alp M Midilli N Kocaba(g)l | 2012 | J Appl Poult Res2012，21，： | 1 |
| 10 | The role of matrix metalloproteinase-2 promoter polymorphisms in coronary artery disease and myocardial infarction显示文摘 | Alp E Menevse S Tulmac M | | 0，，： | 1 |
| 11 | Multidisciplinary treatment of posterior circulation ischemia显示文摘 | Misra M Alp MS Hier D | 2004 | Neurol Res2004，26，1： | 1 |
| 12 | Expression of beta-defensin 1 and 2 in nasal epithelial cells and alveolar macrophages from HIV-infected patients显示文摘 | Alp S Skrygan M Schlottmann R | 2005 | Eur J Med Res2005，10，1： | 1 |
| 13 | The effect of dietary probiotic supplementation on tibial bone characteristics and strength in broilers显示文摘 | Mutus R Kocabagl N Alp M | 2006 | Poultry Science2006，85，： | 1 |
| 14 | Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase Ⅰ overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice显示文摘 | Alp N J McAteer M A Khoo J | 2004 | Arterioscler Thromb Vasc Biol2004，24，3： | 1 |
| 15 | Relationship between blood pressure and outdoor temperature in a large sample of elderly individuals:the three-city study显示文摘 | Alpérovitch A Lacombe J M Hanon O | | 0，，01： | 1 |
| 16 | A rapid troponin-I-based protocol for assessing acute chest pain显示文摘 | ALP N J BELL J A M Shahi | 2001 | QJM2001，94，12： | 1 |
| 17 | Multidisciplinary treatment of posterior circulation ischemia显示文摘 | Misra M AlP M S Hier D | 2004 | Neurol Res2004，26，： | 1 |
| 18 | Current therapeutic strategy inspinal brucellosis显示文摘 | ALP E DOGANAY M | 2008 | Int J Infect Dis2008，12，6： | 1 |
| 19 | TAR-cointegration neural network model:An empirical analysis of exchange rates and stock returns显示文摘 | BILDIRICI M ALP E A ERSIN O O | 2010 | Expert Systems with Applications2010，37，1： | 1 |
| 20 | Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end- stage renal disease显示文摘 | Kayser C Raymond M H Alp I | 2002 | Nutrition Reviews2002，60，11： | 1 |
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