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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | (Ti,Cr)N and Ti/TiN PVD coatings on 304 stainless steel substrates: texture and resid- ual stress显示文摘 | LEONI M SCARDI P ROSSI S | 1999 | Thin Solid Films1999，345，2： | 1 |
| 3 | MAISTAS:a tool for automatic structural evaluation of alternative splicing products显示文摘 | Floris M Raimondo D Leoni G | 2011 | Bioinformatics2011，27，12： | 1 |
| 4 | p-tert-Butylealix arene 显示文摘 | Gutsche C D Dhawan B Leonis M Stewart D | 1990 | Org Synth1990，，68： | 1 |
| 5 | Oxysterols and Alzhei- mer's disease 显示文摘 | Bjorkhem I Heverin M Leoni V | 2006 | Acta Neurol Stand Suppl2006，185，： | 1 |
| 6 | Co-consumption of sugars or ethanol and glucose in a Saccharomyces cerevisiae strain deleted in the HXK2 gene显示文摘 | Leonie M Ramsdonk Jasper A Diderich Arthur Kuiper etal | 2001 | Yeast2001，18，： | 1 |
| 7 | Geochemical explo- ration of the three most significant geothermal areas of Lesbos Island, Greece 显示文摘 | Fytikas M Kavouridis T Leonis C | 1989 | Geothermics1989，18，3： | 1 |
| 8 | A Simple Method to Evaluate the Matrix Effects in X-ray Fluorescence Analysis显示文摘 | FRANZINI M LEONI L SAITfA M | 1972 | X-ray Spectrometry1972，1，4： | 1 |
| 9 | Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: a bridge to transplantation 显示文摘 | Leoni F Gianfaldoni G Annunziata M Fanci R Ciol- li S Nozzoli C | 2002 | Haematologica2002，87，5： | 1 |
| 10 | P-tert-Butylcalix arene Preparation 显示文摘 | Gutsche C D Dhawan B Leonis M Stewart D | 1990 | Organic Syntheses1990，68，： | 1 |
| 11 | Gender and Field of Study as Determi- nants of Self - employment 显示文摘 | LEONI T FALK M | 2010 | Small Business Economic2010，34，： | 1 |
| 12 | (Ti,Cr)N and Ti/TiN PVD coatings on 304 stainless steel substrates:Texture and residual stress显示文摘 | LEONI M SCARDI P ROSSI S | | 0，，02： | 1 |
| 13 | Anisotropic creep model for soft soils显示文摘 | LEONI M KAESTUNEN M VERMEER P A | 2008 | Geotechnique2008，58，3： | 1 |
| 14 | Lhermitte's sign followingoxaliplatin-containing chemotherapy in a cisplatin-pretreated ovar-ian cancer patient显示文摘 | Ciucci G De Giorgi U Leoni M | 2003 | Eur J Neurol2003，10，3： | 1 |
| 15 | Influence of phase stability on the residual stress in partially stabilized zirconia TBC produced by plasma spray 显示文摘 | SCARDI P LEONI M BERTAMINI L | 1995 | Surface and Coatings Technology1995，，7677： | 1 |
| 16 | Arsenic trioxide therapy for relapsed acute promyelocytic leukemia:a bridge to transplantation显示文摘 | Leoni F Gianfaldoni G Annunziata M | 2002 | Haematologica2002，87，5： | 1 |
| 17 | Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of nyc 显示文摘 | LEONI B D NATOLI M NARDELLA M | 2012 | Differentiation2012，83，3： | 1 |
| 18 | Finite element modeling approaches for predicting injury in an experimental model of severe diffuse axonal injury 显示文摘 | Miller RT Margulies SS Leoni M | 1998 | SAE Transactions1998，107，6： | 1 |
| 19 | Anisotropic Creep Model for Soft Soils 显示文摘 | LEONI M KARSTUNEN M VERMEER P A | 2008 | Geotechnique2008，58，3： | 1 |
| 20 | Human digit ratios depend on birth order and sex of older siblings and predict maternal fecundity显示文摘 | Saino N Leoni B Romano M | 2006 | Behav Ecol Sociobiol2006，60，1： | 1 |
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