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| 1 | Patency and agile capsules显示文摘Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture. | ngel Caunedo-lvarez Javier Romero-Vazquez Juan M Herrerias-Gutierrez | 2008 | World Journal of Gastroenterology2008，14，34： | 5 |
| 2 | Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(14 sites), randomized(1:1), open, parallel groups, active controlled trial was done. After inclusion, subjects with acute symptoms of hemorrhoids, who gave their written, informed consent to participate, were centrally randomized to receive, as outpatients, rSK(200000 IU) or 0.25% phenylephrine suppositories, which had different organoleptic characteristics. Treatment was administered by the rectal route, one unit every 6 h during 48 h for rSK, and up to a maximum of 5 d(20 suppositories) for phenylephrine. Evaluations were performed at 3, 5 and 10 d postinclusion. The main end-point was the 5th-day complete clinical response(disappearance of pain and edema, and ≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were evaluated too. RESULTS: 5thday complete response rates were 83/110(75.5%) and 36/110(32.7%) with rSK and phenylephrine suppositories, respectively. This 42.7% difference(95%CI: 30.5-54.2) was highly significant(P < 0.001). The advantage was detected since the early 3rdday evaluation(37.3% vs 6.4% for the rSK and active control groups, respectively; P < 0.001) and was kept even at the late 10thday assessment(83.6% vs 58.2% for rSK and phenylephrine, respectively; P < 0.001). Time for complete response was significantly shorter(P = 0.031; log-rank test) in the rSK group(median: 4.9 d; 95%CI: 4.8-5.0) with respect to the active control(median: 9.8 d; 95%CI: 9.8-10.0). Thrombectomy was necessary in 1/59 and 8/57 patients with baseline thrombosis in the rSK and phenylephrine groups, respectively(P = 0.016). There were no adverse events attributable to the experimental treatment. CONCLUSION: rSK suppositories showed a significant advantage over a widely used over-the-counter phen-ylephrine preparation for the treatment of acute hemorrhoidal illness, with an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura | 2014 | World Journal of Gastroenterology2014，20，6： | 4 |
| 3 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 5 | High carbon dioxide solubilities in trihexyltetradecylphosphonium-based ionic liquids显示文摘 | CARVALHO P J á LVAREZ V H MARRUCHO I M | 2010 | The Journal of Supercritical Fluids2010，52，3： | 1 |
| 6 | A reactivity study of chars obtained at different temperatures in relation to theirpetrographic characteristics 显示文摘 | Alonso M J G Borrego A G álvarez D | 2001 | Fuel Processing Technology2001，，69： | 1 |
| 7 | Repetitive control of tubular heat exchangers显示文摘 | A′LVAREZ J D YEBRA L J BERENGUEL M | 2007 | Journal of Process Control2007，17，9： | 1 |
| 8 | The Effect of Octyl Glucoside on Rheological Behavior of Diluted and ConcentratedLamellar Phases显示文摘 | Granizo N lvarez M Valiente M | 2006 | J Colloid Interface Sci2006，298，1： | 1 |
| 9 | Microstructural characterization of material adhered over cutting tool in the dry machining of aerospace aluminum alloys 显示文摘 | Sanchez J M Rubio E lvarez M A | 2005 | Journal of Materials Processing Technology2005，，： | 1 |
| 10 | A study of oxy-coal combustion with steam addition and biomass blending by thermogravimetric analysis显示文摘 | Gil M V Riaza J (A)lvarez L | | 0，，01： | 1 |
| 11 | Recovery of phenol from aqueous solutions using hollow fibre contactors显示文摘 | GONZALEZ M M J LUQUE S LVAREZ J R A | 2003 | Membr Sci2003，213，： | 1 |
| 12 | A model to study fish DNA immersion vaccination by using the green fluorescent protein显示文摘 | Femandz-A lonso M A lvarez F Estepa A | 1999 | Fish DIS1999，22，7： | 1 |
| 13 | Recovery of phenol from aqueous solutions using hollow fibre contac-tors显示文摘 | Gonzalez M M J Luque S Lvarez J R A | 2003 | Membr Sci2003，213，： | 1 |
| 14 | Nonlinear System Identification with Composite Relevance Vector Machines显示文摘 | Camps-Valls G Martínez-Ramón M Rojo-álvarez J L | 2007 | IEEE Signal Processing Letters2007，14，4： | 1 |
| 15 | Combined effect of concentrations of algal food (Chlorella vulgaris) and salt (sodium chloride) on the population growth of Brachionus calyciflorus and Brachionus patulus (Rotifera)显示文摘 | Peredo-álvarez M V Sarma S S S Nandini S | 2003 | Revista de Biología Tropical2003，51，2： | 1 |
| 16 | A novel fiber optic sensor to monitor beef meat emulsion stability using visible light scattering显示文摘 | LVAREZ D CASTILLO M PAYNE F A | 2009 | Meat Science2009，81，： | 1 |
| 17 | The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of β-carotene into ast-axanthin and other xanthophylls显示文摘 | lvarez V Rodríguez-Sáiz M De La Fuente JL | 2006 | Fungal Genetics and Biology2006，43，4： | 1 |
| 18 | The Effect of Market Orientation on Buyer - seller Relationship Satisfaction 显示文摘 | Sanzo M J Santos M L Va'zquez R A'lvarez LI | 2003 | Induslrial Marketing Management2003，32，4： | 1 |
| 19 | Influence of parent material and soil type on the root chemistry of forest species grown on acid soils显示文摘 | Camps Arbestain M Mourenza C lvarez E A etal | 2004 | Forest Ecology and Management2004，193，3： | 1 |
| 20 | Application of aluminium toxicity indices to soils under various forest species显示文摘 | Lvarez E A Ferna ndez-Marcos M L Monterroso C | 2005 | Forest Ecology and Management2005，211，3： | 1 |
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