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| 1 | Climatology of Lightning Activity in South China and Its Relationships to Precipitation and Convective Available Potential Energy显示文摘这研究在 200112 期间在华南检验了闪电活动和它的关系到降水和对流可得到的势能(披肩) ,基于从广东闪电地点系统,测量使命卫星的热带降雨,和时代过渡期间数据集的数据。高闪电密度的二个区域被识别:在珍珠河三角洲上的,和其它到 Leizhou 半岛的北方。大山峰水流 cloud-to-ground (LPCCG ) 闪电(> 75 kA ) 证明更弱的 landoffshore 比全部的 CG 闪电,否定 cloud-to-ground (NCG ) 闪电比积极 cloud-to-ground (PCG ) 更显著地在发生形成对照土地上的闪电。当全部的 CG 闪电的频率在 8 月在 6 月和第二座山峰显示出一座主要山峰时,在土地上的 LPCCG 闪电在 6 月显示出仅仅一座单个山峰。到全部的闪电的积极 LPCCG 的比率比在一年的另外的时间期间在 FebruaryApril 期间是显著地更大的。每日,在土地上的 CG 闪电在下午显示出仅仅一座山峰,而 CG 闪电近海表演早上和下午山峰。雨收益每越过分析区域的闪光每闪光大概 10 7108 kg,并且它的空间分发对闪电密度的相反。我们在土地上的闪电活动是比那更敏感的在上的数据表演近海流水到披肩。在闪电活动和降水和披肩之间的关系在分析区域与传送对流活动被联系。 | Dong ZHENG Yijun ZHANG Qing MENG Luwen CHEN Jianru DAN | 2016 | Advances in Atmospheric Sciences2016，33，3： | 8 |
| 2 | Predictions of mortality related to four major cancers in China,2020 to 2030显示文摘Background:Cancer has become a global health problem,and assessments of cancer mortality are important for effective public health policy-making and adequate resource allocation.In this study,we aimed to predict the mortality rates and numbers of deaths related to four common cancers(lung,liver,stomach,and esophagus)in China from 2020 to 2030 and to estimate the corresponding cancer burden caused by population aging and tobacco smoking.Methods:Cancer mortality data(2004-2017)were extracted from China’s death surveillance datasets,and China’s population figures(2020-2030)were obtained from the United Nations population projections.Smoking prevalence data were retrieved from a World Health Organization global report,and relative risks of smoking and cancers were derived from large-scale Asian studies.We predicted the deaths related to the four major cancers and age-standardized mortality rates using joinpoint regression and linear regression models.The tobacco smoking related burden of these four major cancers was estimated using the population attributable fraction.Results:Unlike lung cancer mortality which was predicted to continue to increase,the age-standardized mortality rates for digestive cancers(liver,stomach,and esophageal cancers)are predicted to decline over the next decade.The number of deaths caused by the four major cancers is predicted to increase from 1,490,304 in 2020 to 1,823,960 in 2030.The age-specific mortality rates of the four major cancers are predicted to increase with age after 40-45 years,peaking in the age groups of 80-84 and ≥85 years.In 2030,the combined number of deaths from the four examined cancers among adults aged ≥65 years is predicted to be 1,167,153,accounting for 64% of all deaths from these cancers.Tobacco smoking is predicted to contribute to nearly 29% of deaths fromthese cancers,corresponding to 527,577 deaths.Conclusions:The overall trend in the combined total mortality from four major cancers is predicted to decline over the next decade;however,the corresponding death toll is expected to surge,in the context of China’s population aging and high smoking prevalence.These estimates provide data-driven evidence for China to implement effective cancer control measures in the future. | Ning Li Peng Wu Yubing Shen Cuihong Yang Luwen Zhang Yali Chen Zixing Wang Jingmei Jiang | 2021 | Cancer Communications2021，41，5： | 4 |
| 3 | Two basic leader connection scenarios observed in negative lightning attachment process显示文摘High-speed video images of 24 downward negative lightning flashes terminating on tall structures in Guangzhouare selected to analyse the connecting behaviour of the downward and upward leaders during the attachment processpreceding the first return stroke.Three types of leader connecting behaviour have been observed:Type I,the tip ofdownward leader(DL)to the tip of upward connecting leader(UCL),which accounts for 42%of all the events(10/24);Type II,the DL’s tip to the lateral surface of UCL,which accounts for 50%(12/24);and Type III,the combination ofTypes I and II,which accounts for 8%(2/24).For the two cases of Type III behaviour,each case had two junction points(one with Type I and the other with Type II behaviour)between the downward and upward leaders.Therefore,Types Iand II can be viewed as the two basic types of the leader connecting behaviour during the attachment process innegative lightning.No attachment process exhibited the connection of the UCL’s tip to the lateral surface of DL.Thepresence of multiple DL branches and their integrated effect on the development of positive UCL/UCLs are likely to bethe main reasons for the Type II behaviour. | Weitao Lu Qi Qi Ying Ma Luwen Chen Xu Yan Vladimir ARakov Daohong Wang Yijun Zhang | 2016 | High Voltage2016，1，1： | 2 |
| 4 | Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways显示文摘Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor progression.The present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)progression.Here,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor prognosis.Silencing TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen content.Moreover,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy drugs.Thus,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy. | Qiong ZHAO Luwen ZHANG Qiufen HE Hui CHANG Zhiqiang WANG Hongcui CAO Ying ZHOU Ruolang PAN Ye CHEN | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，1： | 1 |
| 5 | Prediction of effective percutaneous transhepatic biliary drainage in patients with hepatocellular carcinoma: A multi-central retrospective study显示文摘Background and aim:Percutaneous transhepatic biliary drainage(PTBD)does not always lead to a reduction in serum total bilirubin(TBil)level in patients with hepatocellular carcinoma and obstructive jaundice.We aimed to develop a model for pre-PTBD prediction of post-procedural TBil decrease in these patients.Materials and methods:Retrospective database searches were conducted at four teaching hospitals(reference period:January 2010 to December 2018),and baseline characteristics of eligible patients were extracted.Any decrease in TBil after PTBD and the lowest level of TBil post-PTBD<5 mg/dL,3 mg/dL,and 2 mg/dL were each taken as the standard of effectiveness for computation of its own predictive nomogram.For data dimension decrease and feature selection,the least absolute shrinkage and selection operator(LASSO)regression model was used.A multivariable logistic regression analysis was used to develop nomograms.Each nomogram's performance was internally evaluated for its calibration,discriminative ability,and clinical usefulness.Results:Included in the study were 138 patients.The model for end-stage liver disease(MELD)score,platelet count,and portal vein thrombosis(PVT)were predictors in the nomogram for any decrease in TBil;international normalized ratio(INR),MELD score,platelet count,and PVT were predictors for a decrease to<5 mg/dL;MELD score,cholinesterase level(CHE),platelet count,and PVT were predictors for a decrease to<3 mg/dL;and MELD score,CHE,platelet count,and pre-albumin level were predictors for a decrease to<2 mg/dL.The clinical value of the nomograms was proven by decision curve analysis.Conclusions:These models may help inform clinical decision making for performing PTBD procedures. | Haofan Wang Yitao Mao Chunning Zhang Xiaojun Hu Bin Chen Luwen Mu Shuyi Wang Yifen Lin Zhanwang Xiang Mingsheng Huang | 2022 | Liver Research2022，6，4： | 1 |
| 6 | A preliminary study on the global land annual precipitation associated with ENSO during 1948-2000显示文摘 | Shi Neng Chen Luwen Xia Dongdong | 2002 | Adv in Atmos Sci2002，19，6： | 1 |
| 7 | Maternal high salt-diet increases offspring's blood pressure with dysfunction of NO/PKGI signaling pathway in heart tissue显示文摘Background:High salt-diets have become significant threats to human health,resulting in hypertension and cardiovascular diseases.Hypertensive disorders during pregnancy are complicated,since the maternal cardiovascular system undergoes extensive physiological changes during pregnancy.High-salt diets during pregnancy can disturb the intrauterine environment and negatively affect fetal development.Therefore,we explored how high-salt diets during pregnancy could affect the offspring.Methods:Rats were divided into three groups and fed with low,normal,and high salt diets.The offspring were separated into three groups after weaning based on dietary salt concentration.The blood pressure and urine protein content of both dams and offspring were measured.To evaluate cardiac function,we used Masson staining and immunodetection to confirm the fibrosis status.Finally,we extracted protein from cardiac tissue to test the expression levels of the Nitric Oxide(NO)/cGMP-dependent protein kinase I(PKGI)pathway and the angiotensin receptor.Results:High-salt diets increased blood pressure,and offspring previously exposed to high-salt environments were predisposed to hypertension.High-salt diets were also found to induce cardiac fibrosis and exacerbate fibrosis in offspring and alter the epithelial-mesenchymal transition(EMT).Under these conditions,the NO/PKGI pathway was activated in cardiac tissue and the type-1angiotensin II receptor(AT1R)was upregulated,though the type-2 angiotensin II receptor(AT2R)had the opposite effect.Conclusion:High-salt diets induce high blood pressure and increase predisposition to hypertension in offspring.They are accompanied by cardiac fibrosis,which could be caused by the activation of NO/PKGI and upregulation of AT1R. | Minshan Huang Xiuying Li Luwen Ren Lin Huang Jiahong Pan Jinlin Yao Lili Du Dunjin Chen Jingsi Chen | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，2： | 1 |
| 8 | A preliminary study on the global land annual precipitation associated with Enso during 1984-2000显示文摘 | Shi Neng Chen Luwen Xia Dongsong | 2002 | Advances in Atmosphere Sciences2002，19，6： | 1 |
| 9 | Association of an Increased Risk of Pre-eclampsia and Fetal Growth Restriction in Singleton and Twin Pregnancies with Female Fetuses显示文摘Objective: To investigate whether the fetal gender affects the incidence of pre-eclampsia (PE) and fetal growth restriction (FGR) in singleton and twin pregnancies.Methods: This was a 10-year single-center, retrospective, cohort study from January 2009 to January 2019. A total of 57,129 singleton and 3699 twin pregnancies aged between 18-55 years old were recruited at the Third Affiliated Hospital of Guangzhou Medical University, China. We used multivariable logistic regression to analyze the effect of fetal gender on the incidence of PE and FGR.Results: In singleton pregnancies, the incidence rates of PE and FGR with a female fetus were higher than those with a male fetus (6.4% (1713/26,793)vs. 5.9% (1803/30,336),P < 0.05 and 3.5% (932/26,793)vs. 2.4% (745/30,336),P < 0.05, respectively). A female fetus was an independent risk factor for either PE or FGR (adjusted odds ratio: 1.169 or 1.563;95% confidence interval: 1.036-1.319 or 1.349-1.810, respectively). In twin pregnancies, the incidence of early-onset PE was greater in pregnancies with two females compared with two males or one male plus one female (4.6% (46/1003)vs. 4.1% (54/1305)vs. 2.4% (33/1391),P < 0.05). Female-female twins was an independent risk factor for PE (adjusted odds ratio: 1.367, 95% confidence interval: 1.011-1.849), especially early-onset PE.Conclusion: The female fetus was associated with PE in both singleton and twin pregnancies and was also a risk factor of FGR in singleton pregnancies. | Shilei Bi Lizi Zhang Zhijian Wang Jingman Tang Sushan Xie Jingjin Gong Lin Lin Luwen Ren Lijun Huang Shanshan Zeng Jingsi Chen Lili Du Dunjin Chen | 2021 | Maternal-Fetal Medicine2021，3，1： | 1 |
| 10 | Flow field analyses of a porous membrane-separated,double-layered microfluidic chip for cell co-culture显示文摘Organs-on-chips composed of a porous membrane-separated,double-layered channels are used widely in elucidating the effects of cell co-culture and flow shear on biological functions.While the diversity of channel geometry and membrane permeability is applied,their quantitative correlation with flow features is still unclear.Immersed boundary methods(IBM)simulations and theoretical modelling were performed in this study.Numerical simulations showed that channel length,height and membrane permeability jointly regulated the flow features of flux,penetration velocity and wall shear stress(WSS).Increase of channel length,lower channel height or membrane permeability monotonically reduced the flow flux,velocity and WSS in upper channel before reaching a plateau.While the flow flux in lower channel monotonically increased with the increase of each factor,the WSS surprisingly exhibited a biphasic pattern with first increase and then decrease with increase of lower channel height.Moreover,the transition threshold of maximum WSS was sensitive to the channel length and membrane permeability.Theoretical modeling,integrating the transmembrane pressure difference and inlet flow flux with chip geometry and membrane permeability,was in good agreement with IBM simulations.These analyses provided theoretical bases for optimizing flow-specified chip design and evaluating flow microenvironments of in vivo tissue. | Shenbao Chen Jian Xue Jinrong Hu Qihan Ding Luwen Zhou Shiliang Feng Yuhong Cui Shouqin Lu Mian Long | 2020 | Acta Mechanica Sinica2020，36，3： | 1 |
| 11 | A Preliminary study on the global land annual precipitation associated with Enso during 1984 -2000 显示文摘 | Shi Neng Chen Luwen Xia Dongsong | 2002 | Advances in Atmosphere Sciences2002，19，6： | 1 |
| 12 | Characteristics of unconnected upward leaders initiated from tall structures observed in Guangzhou显示文摘 | Lu Weitao Chen Luwen Zhang Yang Ma Ying Gao Yan Yin Qiyuan Chen Shaodong Huang Zhihui Zhang Yijun | 2012 | EN2012，，19： | 1 |
| 13 | A preliminary study on the global land annual precipitation associated with ENSO during 1948-2000显示文摘 | Shi Neng Chen Luwen Xia Dongdong | 2002 | Adv Atmos Sci2002，19，6： | 1 |
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