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| 1 | Identification of common microRNA-mRNA regulatory biomodules in human epithelial cancer显示文摘The complex regulatory network between microRNAs and gene expression remains an unclear domain of active research.We proposed to address in part this complex regulation with a novel approach for the genome-wide identification of biomodules derived from paired microRNA and mRNA profiles,which could reveal correlations associated with a complex network of dys-regulation in human cancer.Two published expression datasets for 68 samples with 11 distinct types of epithelial cancers and 21 samples of normal tissues were used,containing microRNA expression and gene expression profiles,respectively.As results,the microRNA expression used jointly with mRNA expression can provide better classifiers of epithelial cancers against normal epithelial tissue than either dataset alone(P=1×10-10,F-test).We identified a combination of 6 microRNA-mRNA biomodules that optimally classified epithelial cancers from normal epithelial tissue(total accuracy = 93.3%;95% confidence intervals:86%-97%),using penalized logistic regression(PLR) algorithm and three-fold cross-validation.Three of these biomodules are individually sufficient to cluster epithelial cancers from normal tissue using mutual information distance.The biomodules contain 10 distinct microRNAs and 98 distinct genes,including well known tumor markers such as miR-15a,miR-30e,IRAK1,TGFBR2,DUSP16,CDC25B and PDCD2.In addition,there is a significant enrichment(Fisher's exact test P=3×10-10) between putative microRNA-target gene pairs reported in 5 microRNA target databases and the inversely correlated microRNA-mRNA pairs in the biomodules.Further,microRNAs and genes in the biomodules were found in abstracts mentioning epithelial cancers(Fisher's Exact test,unadjusted P<0.05).Taken together,these results strongly suggest that the discovered microRNA-mRNA biomodules correspond to regulatory mechanisms common to human epithelial cancer samples.In conclusion,we developed and evaluated a novel comprehensive method to systematically identify,on a genome scale,microRNA-mRNA expression biomodules common to distinct cancers of the same tissue.These biomodules also comprise novel microRNA and genes as well as an imputed regulatory network,which may accelerate the work of cancer biologists as large regulatory maps of cancers can be drawn efficiently for hypothesis generation. | YANG XiNan LEE Younghee FAN Hong SUN Xiao LUSSIER Yves A | 2010 | Chinese Science Bulletin2010，55，31： | 3 |
| 2 | Viscosupplementation with hylan for the treatment of osteoarthritis:Findings from clinical practice in Canada显示文摘 | Lussier A Cividino AA McFarlane CA | | Journal of Rheumatology0，，： | 2 |
| 3 | Automated encoding of clinical documents based on Natural Language Processing显示文摘 | Friedman C Shagina L Lussier Y | 2004 | J Am Med Inform Assoc(S1067-5027)2004，11，5： | 1 |
| 4 | Viscosupplementation with hyalans for the treatment of osteoarthritis:findings from clinical practice in Canada显示文摘 | Lussier A Cividino AA McFarlane CA | 1996 | J Rheum1996，23，9： | 1 |
| 5 | Translational bioinformatics: linking know-ledge across biological and clinicalrealm s显示文摘 | Sarkar IN Butte AJ Lussier Y A | 2011 | J Am Med Inform A ssoc2011，18，4： | 1 |
| 6 | Presence of LH receptor mRNA in granulosa ceils as a potential marker of oocyte developmental competence and characterization of the bovine splicing isoforms 显示文摘 | Robert C Gagne D Lussier J G | 2003 | Reproduction2003，125，： | 1 |
| 7 | Acute and chronic effects of heavy metals and cyanide on Mysidopsis bahia ( crustacea: mysidacea ) 显示文摘 | LUSSIER S M GENTILE J H WALKER J | 1985 | Aquatic Toxicology1985，7，1： | 1 |
| 8 | First -, Second -, and Thrid - Generation Family Firms : A Comparison显示文摘 | SONFIELD M C LUSSIER R N | 2004 | Family Business Review2004，17，3： | 1 |
| 9 | Hsmstring/quadfieeps strength rations in col egiate middle-distance and distance runner显示文摘 | Morris A Lussier L Bel G | | 0，，： | 1 |
| 10 | Loss of cathepsin L activity promotes claudin - 1 overexpression and intestinal neoplasia显示文摘 | Boudreau F Lussier CR Mongrain S | 2007 | FASEB J2007，21，14： | 1 |
| 11 | Continuing education : An aspect of staff development relating to the nurse manages role 显示文摘 | DeMong NC Assie-- Lussier LL | 1999 | J Nurses Staff Dev1999，15，1： | 1 |
| 12 | Effect of CO2Enrichment andHigh Photosynthetic Photon flux on the Development of Autotrophy and Growth of Tissue Cultured Strawberry Raspberry and Asparagus Plants显示文摘 | Desjardins Y Lafoxge F Lussier C | 1988 | Acta Hort1988，230，： | 1 |
| 13 | Acute and chronic effects of heavy metals and cyanide on Mysidopsis bahia (Crustacea: Mysidacea) 显示文摘 | LUSSIER S M GENTILE J H WALKER J | 1985 | Aquatic Toxicology1985，7，12： | 1 |
| 14 | Hepatocyte nuclear factor 4α contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation显示文摘 | Babeu JP Darsigny M Lussier CR | 2009 | Am J Physiol Gastrointest Liver Physiol2009，297，1： | 1 |
| 15 | Effect of CO2 Enrichment andHigh Photosynthetic Photon flux on the Development of Autotrophy and Growth of Tissue Cultured Strawberry Raspberry and Asparagus Plants显示文摘 | Desjardins Y Lafoxge F Lussier C | 1988 | Acta Hort1988，230，： | 1 |
| 16 | Viscosupplementation with hylan for the treatment of osteoarthritis: findings from clinical practice in Canada显示文摘 | Lussier A Cividino AA Mchrlane CA | 1996 | J Rheumatol1996，23，9： | 1 |
| 17 | Enhanced T-cell immu- nity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions显示文摘 | Lussier DM (YNeill L Nieves LM | 2015 | J Immunother2015，38，3： | 1 |
| 18 | Environmental enrichment for the captive spectacled bear(Tre marctos ornatus)显示文摘 | Renner M J Lussier J P | | 0，，01： | 1 |
| 19 | Characterizing rate inhibition in steam/hydrogen gasification via analysis of adsorbed hydrogen显示文摘 | LUSSIER M G ZHANG Z MILLER D J | 1998 | Carbon1998，36，9： | 1 |
| 20 | Developing and using a balanced scorecard:a case study with SWOT analysis显示文摘 | Gumbus A Lussier RN | 2003 | Clin Leadersh Manag Rev2003，17，1： | 1 |
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