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| 1 | Stem cells as delivery vehicles for regenerative medicinechallenges and perspectives显示文摘The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications. Stem-cell-mediated delivery of genes, proteins or small molecules takes advantage of the innate capability of stem cells to migrate and home to injury sites. As the native migratory properties are affected by in vitro expansion, the existent methods for enhancing stem cell targeting capabilities(modified culture methods, genetic modification, cell surface engineering) are described. The role of various nanoparticles in eq-uipping stem cells with therapeutic small molecules is revised together with their class-specific advantages and shortcomings. Modalities to circumvent common challenges when designing a stem-cell-mediated targeted delivery system are described as well as future prospects in using this approach for regenerative medicine applications. | Luminita Labusca Dumitru Daniel Herea Kaveh Mashayekhi | 2018 | World Journal of Stem Cells2018，10，5： | 5 |
| 2 | Adipose tissue in bone regeneration-stem cell source and beyond显示文摘Adipose tissue(AT)is recognized as a complex organ involved in major homeostatic body functions,such as food intake,energy balance,immunomodulation,development and growth,and functioning of the reproductive organs.The role of AT in tissue and organ homeostasis,repair and regeneration is increasingly recognized.Different AT compartments(white AT,brown AT and bone marrow AT)and their interrelation with bone metabolism will be presented.AT-derived stem cell populations-adipose-derived mesenchymal stem cells and pluripotentlike stem cells.Multilineage differentiating stress-enduring and dedifferentiated fat cells can be obtained in relatively high quantities compared to other sources.Their role in different strategies of bone and fracture healing tissue engineering and cell therapy will be described.The current use of AT-or AT-derived stem cell populations for fracture healing and bone regenerative strategies will be presented,as well as major challenges in furthering bone regenerative strategies to clinical settings. | Luminita Labusca | 2022 | World Journal of Stem Cells2022，14，6： | 1 |
| 3 | Understanding host-graft crosstalk for predicting the outcome of stem cell transplantation显示文摘Mesenchymal stromal cells(MSCs)hold great promise for tissue regeneration in debilitating disorders.Despite reported improvements,the short-term outcomes of MSC transplantation,which is possibly linked to poor cell survival,demand extensive investigation.Disease-associated stress microenvironments further complicate outcomes.This debate underscores the need for a deeper understanding of the phenotypes of transplanted MSCs and their environment-induced fluctuations.Additionally,questions arise about how to predict,track,and comprehend cell fate post-transplantation.In vivo cellular imaging has emerged as a critical requirement for both short-and long-term safety and efficacy studies.However,translating preclinical imaging methods to clinical settings remains challenging.The fate and function of transplanted cells within the host environment present intricate challenges,including MSC engraftment,variability,and inconsistencies between preclinical and clinical data.The study explored the impact of high glucose concentrations on MSC survival in diabetic environments,emphasizing mitochondrial factors.Preserving these factors may enhance MSC survival,suggesting potential strategies involving genetic modification,biomaterials,and nanoparticles.Understanding stressors in diabetic patients is crucial for predicting the effects of MSC-based therapies.These multifaceted challenges call for a holistic approach involving the incorporation of large-scale data,computational disease modeling,and possibly artificial intelligence to enable deterministic insights. | Luminita Labusca Florin Zugun-Eloae | 2024 | World Journal of Stem Cells2024，16，3： | 0 |
| 4 | The Utilisation of Marrow Concentrate in Canine Arthrosis—Case Report显示文摘The use of bone marrow concentrate in the treatment of degenerative joint disese(DJD)in dogs represents an innovative approach,minim invasive,that already has been used with increasing success in the veterinary field.The technique,adapted from human medicine for the quadruped patients is based on the principle of the autologous transplant of mesenchymal stem cells that are included in the bone marrow concentrate.The intervention involves a short anesthesia of the animal for harvesting the marrow.The processing of the marrow is realised in strict aseptic conditions in a laboratory and the inoculation is done in the same day.The results are clinically visible after 2-4 weeks.For an enhanced effect,a part of the concentrate is grown on a flask in specific conditions in order to expand autologous bone marrow stem cells and is inoculated after a sufficient number of cells are achieved,usually 3-4 weeks. | Busuioc Diana-Alexandra Sindilar Eusebiu-Viorel Horhogea Cristina Labusca(Simion)Luminita Drugociu Dan | 2019 | Journal of Pharmacy and Pharmacology2019，7，4： | 0 |
| 5 | Stem cells for the treatment of musculoskeletal pain显示文摘Musculoskeletal-related pain is one of the most disabling health conditions affecting more than one third of the adult population worldwide. Pain from various mechanisms and origins is currently underdiagnosed and undertreated. The complexity of molecular mechanisms correlating pain and the progression of musculoskeletal diseases is not yet fully understood. Molecular biomarkers for objective evaluation and treatment follow-up are needed as a step towards targeted treatment of pain as a symptom or as a disease. Stem cell therapy is already under investigation for the treatment of different types of musculoskeletalrelated pain. Mesenchymal stem cell-based therapies are already being tested in various clinical trials that use musculoskeletal system-related pain as the primary or secondary endpoint. Genetically engineered stem cells, as well as induced pluripotent stem cells, offer promising novel perspectives for pain treatment. It is possible that a more focused approach and reassessment of therapeutic goals will contribute to the overall efficacy, as well as to the clinical acceptance of regenerative medicine therapies. This article briefly describes the principal types of musculoskeletal-related pain and reviews the stem cell-based therapies that have been specifically designed for its treatment. | Luminita Labusca Florin Zugun-Eloae Kaveh Mashayekhi | 2015 | World Journal of Stem Cells2015，7，1： | 0 |
| 6 | Human adult pluripotency: Facts and questions显示文摘Cellular reprogramming and induced pluripotent stem cell(IPSC) technology demonstrated the plasticity of adult cell fate, opening a new era of cellular modelling and introducing a versatile therapeutic tool for regenerative medicine.While IPSCs are already involved in clinical trials for various regenerative purposes, critical questions concerning their medium-and long-term genetic and epigenetic stability still need to be answered. Pluripotent stem cells have been described in the last decades in various mammalian and human tissues(such as bone marrow, blood and adipose tissue). We briefly describe the characteristics of human-derived adult stem cells displaying in vitro and/or in vivo pluripotency while highlighting that the common denominators of their isolation or occurrence within tissue are represented by extreme cellular stress. Spontaneous cellular reprogramming as a survival mechanism favoured by senescence and cellular scarcity could represent an adaptative mechanism. Reprogrammed cells could initiate tissue regeneration or tumour formation dependent on the microenvironment characteristics. Systems biology approaches and lineage tracing within living tissues can be used to clarify the origin of adult pluripotent stem cells and their significance for regeneration and disease. | Luminita Labusca Kaveh Mashayekhi | 2019 | World Journal of Stem Cells2019，11，1： | 0 |
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