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| 1 | Arabidopsis CAMTA Transcription Factors Regulate Pipecolic Acid Biosynthesis and Priming of Immunity Genes显示文摘The Arabidopsis thaliana Calmodulin-binding Transcription Activator(CAMTA)transcription factors CAMTA1,CAMTA2,and CAMTA3(CAMTA123)serve as master regulators of salicylic acid(SA)-mediated immunity,repressing the biosynthesis of SA in healthy plants.Here,we show that CAMTA123 also repress the biosynthesis of pipecolic acid(Pip)in healthy plants.Loss of CAMTA123 function resulted in the induction of AGD2-like defense response protein 1(ALD1),which encodes an enzyme involved in Pip biosynthesis.Induction of ALD1 resulted in the accumulation of high levels of Pip,which brought about increased levels of the SA receptor protein NPR1 without induction of NPR1 expression or requirement for an increase in SA levels.Pip-mediated induction of ALD1 and genes regulating the biosynthesis of SA—CBP60g,SARD1,PAD4,and EDS1—was largely dependent on NPR1.Furthermore,Pip-mediated increase in NPR1 protein levels was associated with priming of Pip and SA biosynthesis genes to induction by low levels of SA.Taken together,our findings expand the role for CAMTA123 in regulating key immunity genes and suggest a working model whereby loss of CAMTA123 repression leads to the induction of plant defense genes and initiation of SAR. | Yongsig Kim Sarah J.Gilmour Lumen Chao Sunchung Park Michael F.Thomashow | 2020 | Molecular Plant2020，13，1： | 8 |
| 2 | RGK regulation of voltage-gated calcium channels显示文摘Voltage-gated calcium channels(VGCCs) play critical roles in cardiac and skeletal muscle contractions,hormone and neurotransmitter release,as well as slower processes such as cell proliferation,differentiation,migration and death.Mutations in VGCCs lead to numerous cardiac,muscle and neurological disease,and their physiological function is tightly regulated by kinases,phosphatases,G-proteins,calmodulin and many other proteins.Fifteen years ago,RGK proteins were discovered as the most potent endogenous regulators of VGCCs.They are a family of monomeric GTPases(Rad,Rem,Rem2,and Gem/Kir),in the superfamily of Ras GTPases,and they have two known functions: regulation of cytoskeletal dynamics including dendritic arborization and inhibition of VGCCs.Here we review the mechanisms and molecular determinants of RGK-mediated VGCC inhibition,the physiological impact of this inhibition,and recent evidence linking the two known RGK functions. | BURAEI Zafir LUMEN Ellie KAUR Sukhjinder YANG Jian | 2015 | Science China(Life Sciences)2015，58，1： | 4 |
| 3 | Lunasin,a novel seed peptide for cancer prevention显示文摘 | Hernández-Ledesma B Hsieh C C de Lumen B O | 2009 | Peptides2009，30，2： | 1 |
| 4 | Barley lunasin suppresses rasinduced colony formation and inhibits core histone acetylation in mammalian cells显示文摘 | Jeong H J Lam Y de Lumen B O | 2002 | J Agric Food Chem2002，50，21： | 1 |
| 5 | Lunasin concentration in different soybean genotypescommercial soy protein and isoflavone products显示文摘 | Elvira Gonzalez De Mejia Miguel Vasconez Ben O de Lumen | 2004 | Agricultural and Food Chemistry2004，52，： | 1 |
| 6 | Population screening for prostate cancer:an overview of available studies and meta-analysis显示文摘 | Lumen N Fonteyne V De Meerleert G | | 0，，： | 1 |
| 7 | Challenging non-traumatic posterior urethral strictures treated with urethroplasty:A preliminary report显示文摘 | Lumen N Oosterlinck W | | 0，，04： | 1 |
| 8 | Population screening for prostate cancer:an overview of available studies and meta- analysis显示文摘 | Lumen N Fonteyne V De Meerleert G | 2012 | Int J Urol2012，19，2： | 1 |
| 9 | Lunasin and Bowman-Birk protease inhibitor (BBI) in US commercial soy foods显示文摘 | Hernández-Ledesma B Hsieh C C de Lumen B O | 2009 | Food Chem2009，115，2： | 1 |
| 10 | Challenging non-traumatic posterior urethral strictures treated with urethroplasty: a preliminary report 显示文摘 | Lumen N Oosterlinck W | 2009 | Int Braz J Uroi2009，35，4： | 1 |
| 11 | Formation of volatile flavor compounds in greeit bean form linoleic and linoleic acids显示文摘 | LUMEN B O STONE E J KAZENIAC S J ct al | 1978 | J Food Sci1978，43，3： | 1 |
| 12 | Challenging non-traumatic posterior urethral stricturestreated with urethroplastv:A preliminan report显示文摘 | Lumen N Oosterliuck W | 2009 | lnt Braz JUrol2009，，4： | 1 |
| 13 | Contents and bioactivities of lunasin,Bowman-Birk Inhibitor,and isoflavones in soybean seed显示文摘 | Park J H Jeong H J de Lumen B O | 2005 | J Agric Food Chem2005，53，20： | 1 |
| 14 | In vitro degestibility of the cancer-preventive soy peptides Lunasin and BBI 显示文摘 | Park JH Jeong HJ Lumen BO | 2007 | Agric Food Chem2007，55，10： | 1 |
| 15 | Salvagepelvic lymph node dissection in recurrent prostate cancer :surgical and early oncological outcome显示文摘 | CLAEYS T VAN PRAET C LUMEN N | 2015 | Biomed ResInt2015，2015，19： | 1 |
| 16 | Lunasin concentration in different soybean genotypes, commercial soy protein, and isoflavone products显示文摘 | de MEJIA E G VASCONEZ M de LUMEN B O | 2004 | J Agric Food Chem2004，52，19： | 1 |
| 17 | Contents and bioactivities of Lunasin, Bowman-Birk Inhibitor, and Iso?avones in soybean seed 显示文摘 | Park JH Jeong H J Lumen BO | 2005 | Agric Food Chem2005，53，： | 1 |
| 18 | Lunasin suppresses E1A-mediated transformation of mammalian cells but does not inhibit growth of immortalized and established cancer cell lines显示文摘 | Lam Y Galvez A de Lumen B O | 2003 | Nutr Cancer2003，47，1： | 1 |
| 19 | Barley Lunasin suppresses ras-induced colony formation and inhibits core histone acetylation in mammalian cells显示文摘 | Jeong H J Larn YI and Lumen BO | 2002 | Agric Food Chem2002，50，： | 1 |
| 20 | Presence of lunasin in plasma of men after soy protein consumption显示文摘 | DIA V P TORRES S DE LUMEN B O | 2009 | Journal of Agricultural and Food Chemistry2009，57，4： | 1 |
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