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| 1 | Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors 显示文摘 | KURTZ A LUETH M KLUWE L | 2004 | Mol Cancer Re2004，2，8： | 1 |
| 2 | Robot Control in Maxillofacial Surgery 显示文摘 | HEIN A LUETH T C | 2000 | Experimental Robotics2000，，4： | 1 |
| 3 | Coffee and caffeine intake and the risk of ovarian cancer:the Iowa Women's Health Study显示文摘 | Lueth NA Anderson KE Harnack LJ | 2008 | Cancer Causes Control2008，19，10： | 1 |
| 4 | Tracking of the liver for navigation in open surgery显示文摘 | Markert M Koschany A Lueth T | 2010 | Int J Comput Assist Radiol Surg2010，5，3： | 1 |
| 5 | Emission reduction strategies for Central and Eastern Europe显示文摘 | O Lueth A Jattke H Schoettle | 1997 | Elsevier1997，25，3： | 1 |
| 6 | Robot-assisted place- ment of craniofacial implants显示文摘 | Klein M Hein A Lueth T | 2003 | Int J Oral Maxillofac Im- plants2003，18，5： | 1 |
| 7 | Fresnel-volume multicomponent migration 显示文摘 | Goerlz A Muller C Buske S Lueth S | 2003 | EAGE 65th Conference and Exhibition2003，99，： | 1 |
| 8 | Manual registration of ultrasound with CT/planning data for hepatic surgery显示文摘 | Markert M Weber S Lueth TC | 2007 | Stud Health Technol Inform2007，125，： | 1 |
| 9 | An agglomerate model of lithium-ion battery cathodes显示文摘 | LUETH S SAUTER U S BESSLER W G | 2016 | Journal of the Electrochemical Society2016，163，2： | 1 |
| 10 | Quantitative assessment of parkinsonian bradykinesia based on an inertial measurement unit显示文摘 | Dai H Lin H Lueth TC | 2015 | Biomed Eng Online2015，14，： | 1 |
| 11 | RoboPoint an au toclavable interactive miniature robot for surgery and interventional radiology 显示文摘 | Schauer D Hein A Lueth T C | 2003 | International Congress Series2003，1256，： | 1 |
| 12 | Robot-assisted placement of craniofacial implants 显示文摘 | Klein M Hein A Lueth T | 2003 | Int J Oral Maxillofac Implants2003，18，5： | 1 |
| 13 | Detection of mitoehondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients显示文摘 | Wong L J Lueth M Li X N | 2003 | Cancer Res2003，63，14： | 1 |
| 14 | ALT screeningfor chronic liver diseases:scrutinizing the evidence显示文摘 | Wedemeyer H Hofmann WP Lueth S | 2010 | ZGastroenterol2010，48，1： | 1 |
| 15 | The Sincos Project - geosphere Ecosphere and An-throposphere of the Holocene Southern Baltic Sea显示文摘 | Harff Jan Lueth Friedrich | 2009 | Baltica2009，22，2： | 1 |
| 16 | A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection显示文摘 | Andrew J. Muir Sanjeev Arora Gregory Everson Robert Flisiak Jacob George Reem Ghalib Stuart C. Gordon Todd Gray Susan Greenbloom Tarek Hassanein Jan Hillson Maria Arantxa Horga Ira M. Jacobson Lennox Jeffers Kris V. Kowdley Eric Lawitz Stefan Lueth Maribe | 2014 | Journal of Hepatology2014，，： | 1 |
| 17 | Somatic mitochondrial mutat-ions in pilocytic astrocytoma显示文摘 | Lueth M WronskL I Giese A | 2009 | Cancer Genet Cytogenet2009，192，1： | 1 |
| 18 | Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1显示文摘AIM: To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin(peg IFN/RBV), in treatment-naive hepatitis C virus(HCV) genotype(GT) 1-infected patients.METHODS: In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned(2:1) to daclatasvir vs telaprevir, stratified by IL28 B rs12979860 host genotype(CC vs non-CC), cirrhosis status(compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype(GT1a vs GT1b). Patients were selected by study inclusion criteria from a total of 793 enrolled patients. Patients received daclatasvir 60 mg once daily or telaprevir 750 mg 3 times daily plus peg IFN/RBV. Daclatasvir recipients received 24 wk of daclatasvir plus peg IFN/RBV; those without an extended rapid virologic response(e RVR; undetectable HCV-RNA at weeks 4 and 12) received an additional 24 wk of peg IFN/RBV. Telaprevir-treated patients received 12 wk of telaprevir plus peg IFN/RBV followed by 12(with e RVR) or 36(no e RVR) wk of peg IFN/RBV. The primary objective was to compare for noninferiority of sustained virologic response rates at posttreatment week 12(SVR12) in GT1b-infected patients. Key secondary objectives were to demonstrate that the rates of anemia(hemoglobin < 10 g/d L) and rashrelated events, through week 12, were lower with daclatasvir + peg IFN/RBV than with telaprevir + peg IFN/RBV among GT1b-infected patients. Resistance testing was performed using population-based sequencing of the NS5 A region for all patients at baseline, and for patients with virologic failure or relapse and HCV-RNA ≥ 1000 IU/m L, to investigate any link between NS5 A polymorphisms associated with daclatasvir resistance and virologic outcome. RESULTS: Patient demographics and disease characteristics were generally balanced across treatment arms; however, there was a higher proportion of black/African Americans in the daclatasvir groups(6.0% and 8.2% in the GT1 b and GT1 a groups, respectively) than in the telaprevir groups(2.2% and 3.0%). Among GT1 binfected patients, daclatasvir plus peg IFN/RBV was noninferior to telaprevir plus peg IFN/RBV for SVR12 [85%(228/268) vs 81%(109/134); difference, 4.3%(95%CI:-3.3% to 11.9%)]. Anemia(hemoglobin < 10 g/d L) was significantly less frequent with daclatasvir than with telaprevir [difference,-29.1%(95%CI:-38.8% to-19.4%)]. Rash-related events were also less common with daclatasvir than with telaprevir, but the difference was not statistically significant. In GT1 ainfected patients, SVR12 was 64.9% with daclatasvir and 69.7% with telaprevir. Among both daclatasvir and telaprevir treatment groups, across GT1b- or GT1a-infected patients, lower response rates were observed in patients with IL28 B non-CC and cirrhosis- factors known to affect response to peg IFN/RBV. Consistent with these observations, a multivariate logistic regression analysis in GT1b-infected patients d e m o n s t ra t e d t h a t S V R 1 2 wa s a s s o c i a t e d w i t h IL28 B host genotype(CC vs non-CC, P = 0.011) and cirrhosis status(absent vs present, P = 0.031). NS5 A polymorphisms associated with daclatasvir resistance(at L28, R30, L31, or Y93) were observed in 17.3% of GT1b-infected patients at baseline; such variants did not appear to be absolute predictors of failure since 72.1% of these patients achieved SVR12 compared with 86.9% without these polymorphisms. Among GT1b-infected patients, treatment was completed by 85.4%(229/268) in the daclatasvir group, and by 85.1%(114/134) in the telaprevir group, and among GT1a-infected patients, by 67.2%(90/134) and 69.7%(46/66), respectively. Discontinuations(of all 3 agents) due to an AE were more frequent with telaprevir than with daclatasvir, whereas discontinuations due to lack of efficacy were more frequent with daclatasvir, due, in part, to differences in futility criteria. CONCLUSION: Daclatasvir plus peg IFN/RBV demonstrated noninferiority to telaprevir plus peg IFN/RBV for SVR12 and was well-tolerated in treatment-naive GT1 binfected patients, supporting the use of daclatasvir with other direct-acting antivirals. | Ira Jacobson Stefan Zeuzem Robert Flisiak Brygida Knysz Stefan Lueth Dorota Zarebska-Michaluk Ewa Janczewska Peter Ferenci Moises Diago Anna Linda Zignego Rifaat Safadi Yaacov Baruch Dzhamal Abdurakhmanov Stephen Shafran Dominique Thabut Rafael Bruck Adrian Gadano Alexander James Thompson Justin Kopit Fiona Mc Phee Tracy Michener Eric A Hughes Philip D Yin Stephanie Noviello | 2016 | World Journal of Gastroenterology2016，22，12： | 1 |
| 19 | ALT screening for chronic liver diseases: scrutinizing the evidence显示文摘 | Wedemeyer H Hofmann WP Lueth S | 2010 | Gastroenterol2010，348，1： | 1 |
| 20 | Lectin histochemistry of the gastric mucosa in normal and Helicobacter pylori infected guinea-pigs显示文摘 | LUETH M STUREGARD E SJUNNESSON H | 2005 | J Mol Histol2005，36，12： | 1 |
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