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| 1 | Antioxidant Effect of a Novel Class of Telluroacetilene Compounds:studies in Vitro and in Vivo显示文摘 | A C G Souza C Luchese J S Santos Neto | 2009 | Life Science2009，84，1112： | 1 |
| 2 | Protective effect of diphenyl diselenide on ischemia and reperfusion-induced cerebral injury:involvement of oxidative stress and pro-inflammatory cytokines显示文摘 | Brüning CA Prigol M Luchese C | | 0，，10： | 1 |
| 3 | Accidental extubation in a pediatric intensive care unit显示文摘 | Piva JP Amantea S Luchese S | | 0，，71： | 1 |
| 4 | Growth of and aflatoxin production by Aspergillus parasiticus when in the presence of Streptococcus lactis or lactic acid and at different initial pH values 显示文摘 | LUCHESE R H HARRIGAN W F | 1990 | J Appl Bacteriol1990，69，： | 1 |
| 5 | Electrical and optical properties of ITO and ITO/Cr-doped ITO films显示文摘 | A. P. Caricato M. Cesaria A. Luches M. Martino G. Maruccio D. Valerini M. Catalano A. Cola M. G. Manera M. Lomascolo A. Taurino R. Rella | 2010 | Applied Physics A2010，，4： | 1 |
| 6 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 7 | Protective effect of diphenyl diselenide on ischemia and reperfusion-induced cerebral injury: involvement of oxidative stress and pro-inflammatory cytokines 显示文摘 | Bruning CA Prigol M Luchese C | 2012 | Neurochem Res2012，37，10： | 1 |
| 8 | Ochratoxin A on green coffee:Influence of harvestand drying processingprocedures显示文摘 | MARIA HELOISA PAULINO DE MORAES ROSA HELENA LUCHESE | 2003 | J Agric Food Chem2003，51，： | 1 |
| 9 | Micronized benzoic acid decreases the concentration necessary to preserve acidic beverages against Alicyclobacillus显示文摘 | KAWASE K Y F LUCHESE R H COELHO G L | 2013 | Journal of Applied Microbiology2013，115，2： | 1 |
| 10 | Study of global left atrial shortening in fetuses of diabetic mothers显示文摘 | Zielinsky P Satler F Luchese S | 2004 | Arq Bras Cardiol2004，83，6： | 1 |
| 11 | Antioxidant effect of diphenyl diselenide on oxidative damage induced by smoke in rats: involvement of glutathione显示文摘 | Luchese C Eluza C Stangherlin | 2009 | Ecotoxicol Environ Saf2009，72，： | 1 |
| 12 | Intrauterine ductus arteriosus constriction: analysis of a historic cohort of 20 cases 显示文摘 | Luchese S Manica J Zielinsky P | 2003 | Arq Bras Cardiol2003，81，： | 1 |
| 13 | Influence of Blueberry and Jaboticaba Agroindustrial Residue Particle Size on Color Change of Corn Starch Based Films Submitted to Different pH Values Solutions显示文摘Corn starch,glycerol and agroindustrial residues were used to produce films by casting.By-products from juice processing,blueberry and jaboticaba in powder with different particle sizes were added in the filmogenic matrix to evaluate its potential as a colorimetric indicator.Blueberry and jaboticaba peels are commonly discarded although contain high amount of important compounds as anthocyanins.These compounds have the ability to color change after immersion in different pH values,demonstrating its potential for the intelligent packaging development.Analyses were performed in a colorimeter after films immersion in different buffer solutions.Visual color changes were perceived;reddish and bluish color in acidic and basic pH values,respectively.Independently of the particle size,theΔE* values were greater than 5,showing visually perceptible change to the human eye.The results indicate the potential of use of these residues as a pH indicator for the development of renewable and biodegradable sensor of food deterioration. | Cláudia Leites Luchese Julia Menegotto Frick Pavoni Jordana Corralo Spada Isabel Cristina Tessaro | 2019 | Journal of Renewable Materials2019，7，3： | 0 |
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