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| 1 | Long-term outcomes of interventions for radiation-induced xerostomia:A review显示文摘Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms 'xerostomia' and 'radiation' or 'radiotherapy'; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or practical.The use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions. | Sung Jun Ma Charlotte I Rivers Lucas M Serra Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 4 |
| 2 | Expression of a inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA显示文摘 | Schachtman D P Schroeder J I Lucas W | 1992 | Science1992，258，： | 1 |
| 3 | Experimental study of passive systems thermal performance显示文摘 | Lucas I B Hoese(A) L Pontoriero D | 2000 | Renewable Energy2000，19，12： | 1 |
| 4 | Atmospheric microwave plasma jet for material processing显示文摘 | Al-Shamma'a A I Wylie S R Lucas J | 2002 | IEEE Transaction on Plasma Science2002，30，5： | 1 |
| 5 | Synthesis of titanium oxide parti- cles in supercritical CO2: Effect of operational variables in the character- istics of the final product显示文摘 | Alonso E Montequi I Lucas S | 2007 | The Journal of Supercritcal Fluids2007，39，3： | 1 |
| 6 | Cardiac reperfusion injury: aging, lipid peroxidation,and mitochondrial dysfunction显示文摘 | Lucas D T Szweda L I | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 7 | Multiple forms of angiostatin induce apoptosis in endothelial cells显示文摘 | Lucas R Holmgren L Garcia I | 1998 | Blood1998，92，12： | 1 |
| 8 | Accuracy accessment of sattelite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEI V D | 1994 | Potogramatic Engineering & Remote Sensing1994，60，4： | 1 |
| 9 | Inhibition of angiotensin converting enzyme (ACE) activity by flavan - 3 - ols and procyanidins 显示文摘 | Lucas Actis -Goretta Javier I Ottaviani Carl L Keen | 2003 | FEBS let- ters2003，555，3： | 1 |
| 10 | Accuracy assessment of satellite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEL V D | 1994 | Photogrammetric Engineering & Remote Sensing1994，60，4： | 1 |
| 11 | Effects of deletion of the prolactin receptor on ovarian gene expression显示文摘 | Grosdemouge I Bachelot A Lucas A | 2003 | Reprod Biol Endocrinol2003，1，： | 1 |
| 12 | Robust stability analysis of Smith predictor-based congestion control algorithms for computer networks显示文摘 | Luca D C Mascoloa S Niculescu S I | 2011 | Automatica2011，47，8： | 1 |
| 13 | Magnetic properties of Co-P alloys electrodeposited at room temperature显示文摘 | Lucas I Perez L Aroca C | 2005 | Journal of Magnetism and Magnetic Materials2005，，： | 1 |
| 14 | Utilization of metabolic scope in relation to feeding and activity by individual and grouped zebrafish, Brachydanio rerio ( Hamilton-Buchanan ) 显示文摘 | Lucas M C Priede I G | 1992 | J Fish Biol1992，41，： | 1 |
| 15 | A new therapeutic strategy for electrical cardioversion of atrial fibrillation 显示文摘 | de Luca I Sorino M Del Salvatore B | 2001 | Italian Heart Journal2001，2，： | 1 |
| 16 | Physical properties and microstructure of yoghurts supplemented with milk protein hydrolysates显示文摘 | I Sodini A Lucas J P Tissier G Corrieu | 2005 | International Dairy Journal2005，15，： | 1 |
| 17 | The phenotype of soluble starch synthase Ⅳ defective mutants of Arabidopsis thaliana suggests a novel function of elongation enzymes in the control of starch granule formation显示文摘 | Roldan I Wattebled F Lucas M | 2007 | The Plant Journal2007，49，3： | 1 |
| 18 | Cytochrome P4502E1 Inducibility and Hydroxyethyl Radical Formation among Alcoholics显示文摘 | Lucas D Clot P | 1998 | Hepatol1998，28，4： | 1 |
| 19 | Multiple forms of angiostatin induces apoptosis in endothelial cells 显示文摘 | Lucas R Holmgren L Garcia I | 1998 | Blood1998，92，12： | 1 |
| 20 | Atmospheric microwave plasma jet for material processing显示文摘 | AI-Shamma' A A I Wylie S R Lucas J | 2002 | IEEE Transactions on Plas ma Science2002，30，5： | 1 |
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