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| 1 | Thrombin activation and liver inflammation in advanced hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis. | Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández | 2016 | World Journal of Gastroenterology2016，22，18： | 5 |
| 2 | Overlap of reflux and eosinophilic esophagitis in two patients requiring different therapies:A review of the literature显示文摘Eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD) have overlapping clinical, manometric, endoscopic and histopathologic features. The diagnosis of EE is nowadays based upon the presence of 15 or more eosinophils per high power field (eo/HPF) in esophageal biopsies. We report the cases of two young males suffering from dysphagia and recurrent food impaction with reflux esophagitis and more than 20 eo/HPF in upper-mid esophagus biopsies, both of which became asymptomatic on proton pump inhibitor (PPI) therapy. The first patient also achieved a histologic response, while EE remained in the other patient after effective PPI treatment, as shown by 24-h esophageal pH monitoring. Topical steroid therapy combined with PPI led to complete remission in this latter patient. GERD and EE may be undistinguishable, even by histology, so diagnosis of EE should only be established after a careful correlation of clinical, endoscopic and pathologic data obtained under vigorous acid suppression. These diagnostic difficulties are maximal when both diseases overlap. Limited data are available about this topic, and the interaction between EE and GERD is a matter of debate. In this setting, upper-mid esophagus step biopsies and esophageal pH monitoring of patients on PPI therapy are pivotal to evaluate the role of each disease. A PPI trial is mandatory in patients with a histopathologic diagnosis of EE; in those unresponsive to PPI treatment, EE should be suggested. However, a clinical response to PPI may not rule out quiescent EE, as shown in this report. | Javier Molina-Infante Lucía Ferrando-Lamana Jose María Mateos-Rodríguez Belén Pérez-Gallardo Ana Beatriz Prieto-Bermejo | 2008 | World Journal of Gastroenterology2008，14，9： | 2 |
| 3 | The relevance of size efficiency to biomanipulation theory:a field test under hypertrophic conditions显示文摘 | Steven D Luc D M Nicole P | 1997 | Hydrobiologia1997，360，： | 2 |
| 4 | Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives显示文摘 | Valérie Planat-Benard Jean-Sébastien Silvestre Béatrice Cousin Mireille André Maryse Nibbelink Radia Tamarat Michel Clergue Carole Manneville Corinne Saillan-Barreau Micheline Duriez Alain Tedgui Bernard Levy Luc Pénicaud Louis Casteilla | 2004 | Circulation: Journal of the American Heart Association2004，，5： | 2 |
| 5 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 6 | Interleukin18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myoc-ard ial Intaretion (PRIME) 显示文摘 | Blankenberg S Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 7 | Mobile phone follow-up of subjects include in a prospective cohort study: unexpected difficulties 显示文摘 | Isabelle P Luc D Laurent B | 2007 | Eur J Epidemiol2007，22，： | 1 |
| 8 | Interleukin-18 and the risk of coronary heart disease in European men:the Prospective Epidemiological Study of Myocardial Infarction (PRIME)显示文摘 | Blankenberg S Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 9 | Consensus-based decentralized auctions for robust task allocation显示文摘 | Choi Han-Lim Brunet Luc Jonathan P | | 0，，04： | 1 |
| 10 | Interleukin-18and the risk of coronary heart disease in European men:the Prospective Epidemiological Study of Myocar dial In-farction显示文摘 | Blankenberg S Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 11 | Interleukin-18,a the risk of coronary heart disease in European men:the prospective Epidemiological Study of Myocardial Infarction(PRIME)显示文摘 | Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 12 | tL-18 and the risk of coronary heart disease in European men : the Prospective Epidemiological Study of Myocardial infarction (PRIME) 显示文摘 | Blankenberg S Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 13 | Finite Element Simulation of Spring Back in Sheet Metal Forming显示文摘 | Luc P Jean P P | 2002 | Journal of Materials Processing Technology2002，，： | 1 |
| 14 | Interleukin-18 and the risk of coronary heart disease in European men:the Prospective Epidemiological Study of Myocardial Infarction显示文摘 | Blankenberg S Luc G Ducimetiere P | 2003 | Circulation2003，108，20： | 1 |
| 15 | Interleukin-18 and the risk of coronary heart disease in European men : the prospective epidemiological study myocardial infaraction (PRIME) 显示文摘 | Blankenbergs S Luc G Ducimetere P | 2003 | Circulation2003，108，9： | 1 |
| 16 | Contribution of novel biomarkers to incident stable angina and acute coronary syndrome:the PRIME Study显示文摘 | Empana J P Canoui-Poitrine F Luc G | 2008 | Eur Heart J2008，29，16： | 1 |
| 17 | Interleukin-1 g and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction(PRIME)显示文摘 | Blankenberg S Luc G Ducimetiere P Arveiler D Ferrieres J Amouyel P | 2003 | Circulation2003，108，： | 1 |
| 18 | Reversible polymers formed from self-complementary monomers using quadruple hydrogen bonding 显示文摘 | Rint P Sijbesma Felix H Berjer Luc Brunsveld | 1997 | Science1997，278，： | 1 |
| 19 | Contributions of depressivemood and circulating inflammatory markers to coronary heartdisease in healthy European:The prospective epidemiological studyof myocardial infarction(PRIME)显示文摘 | Empana J P Sykes D H Luc G | 2005 | Circulation2005，111，7： | 1 |
| 20 | Intedeukin-18 and the risk of coronary heart disease in European men:the Prospective Epidemiological Study of Myocardial Infarction (PRIME)显示文摘 | Blankenberg S Luc G Ducimetiere P PRIME Study Group | 2003 | Circulation2003，108，20： | 1 |
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