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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 3 | The Simultaneous Repression Of CCR and CAD, Two Enzymes of the Lignin Biosynthetic Pathway, Results in Sterility and Dwarfism in Arabidopsis thaliana显示文摘Cinnamoyl CoA reductase (CCR ) 和 cinnamyl 白酒脱氢酶(CAD ) 催化 monolignol 生合成的最后步骤。在 Arabidopsis,一 CCR 基因(CCR1, At1g15950 ) 并且二 CAD 基因(CAD C At3g19450 和 CAD D At4g34230 ) 涉及这条小径。三倍的恶棍 c 恶棍 d ccr1 变异的、命名 ccc,被获得。这异种显示严格的矮子显型和男绝育。在 ccc 的木质素内容成熟的茎被归结为 50% 野类型的水平。另外,茎木质素结构严重地被影响,在抵抗内部单位的契约和加入由戏剧的丰富出现进象 coniferaldehyde 那样的 monolignol 先锋的聚合物 sinapaldehyde,和 ferulic 酸。男绝育由于在花药内层的木质化的缺乏,它引起花药裂开并且花粉版本的失败。ccc hypolignified 茎积累黄酮醇 glycosides, sinapoyl malate 和 feruloyl malate 的更高的数量,它建议酉分的小径的重定向。因此, CAD 和 CCR 的缺席, monolignol 小径的关键酶,比他们中的每的单个缺席在显型上有更严重的后果。另一 CCR 感应(CCR2, At1g80820 ) 并且另一 CAD (CAD1, At4g39330 ) 不补偿主要 CCR 和 CAD 活动的缺席。CCR 和 CAD 活动的这缺乏不仅影响木质化,而且严重地影响植物的发展。当试着减少植物的木质素内容以便便于 lignocellulose-to-bioethanol 变换过程时,这些后果必须小心地被考虑。 | Johanne Thevenin Brigitte Pollet Bruno Letarnec Luc Saulnier Lionel Gissot Alessandra Maia-Grondard Catherine Lapierre Lise Jouanin | 2011 | Molecular Plant2011，4，1： | 18 |
| 4 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 5 | 自密实混凝土高温爆裂性能影响因素的试验研究显示文摘对自密实混凝土、掺加聚丙烯纤维的自密实混凝土与高强混凝土进行高温爆裂试验,对不同升温速率、不同聚丙烯纤维掺量、不同应力水平进行综合研究。为了清楚地了解自密实混凝土在高温下爆裂的本质特征,通过环境扫描电镜和汞压力测孔法对混凝土高温下微观性能进行研究,还进行高温后材料的气渗性能测试。分析初始应力、纤维掺量、不同升温机制等对混凝土爆裂性能的影响,建立自密实混凝土高温爆裂性能与微观组成结构之间的联系,揭示不同影响因素对自密实混凝土高温爆裂性能产生影响的本质原因。试验结果表明初始应力是影响自密实混凝土爆裂的重要因素,且一定掺量的聚丙烯纤维对抑制自密实混凝土高温爆裂具有显著的作用,最后探讨聚丙烯纤维作用机理,提出自密实混凝土高温爆裂抑制措施,对于自密实混凝土的大规模推广和应用具有重要实际意义。 | 陶津 柳献 袁勇 Luc Taerwe | 2009 | 土木工程学报2009，42，10： | 15 |
| 6 | 抗生素相关性腹泻的治疗 微生态制剂可能有助于预防显示文摘腹泻是抗生素治疗过程中一种常见的不良作用。5%~30%的患者在抗生素治疗早期或治疗结束后2个月内会发生抗生素相关性腹泻。抗生素相关性腹泻的发生率取决于对腹泻的定义、所使用的抗生素种类和宿主的个体因素。 | FrédéricBarbut Jean Luc Meynard 范洪伟 | 2003 | 英国医学杂志中文版2003，6，1： | 15 |
| 7 | 利用颜色的非刚性物体跟踪方法(英文)显示文摘提出了一个利用颜色特征实时跟踪非刚性物体的方法 .首先 ,建立了一个颜色分布模型 ,该模型对部分遮挡具鲁棒性 ,对放缩和旋转具不变性 ,且计算简单 .对非刚体物体的实时鲁棒跟踪是一个非常有挑战性的课题 ,本文提出了利用颜色特征实时跟踪非刚体物体的方法 .首先 ,建立了一个颜色分布模型 ,该模型对部分遮挡具有鲁棒性 ,对放缩具有不变性 ,而且计算简单 .然后 ,采用粒子滤波的方法将颜色分布模型集成到一个动态状态估计的概率框架中 .为了处理光照变化等引起的外貌变化 ,进一步引入自适应模型更新过程 .同时 。 | Katja Nummiaro Esther Koller-Meier Luc Van Gool | 2003 | 自动化学报2003，29，3： | 15 |
| 8 | Speeded-Up Robust Features (SURF)显示文摘 | Herbert Bay Andreas Ess Tinne Tuytelaars Luc Van Gool | 2007 | Computer Vision and Image Understanding2007，，3： | 14 |
| 9 | 半干旱黄土丘陵区纯林土壤腐殖质异化特征及与其他性质的关系显示文摘纯林长期生长或多代连栽必然会导致土壤腐殖质含量和构成发生异化,探究这种异化特征及其与土壤其他性质的关系可以为纯林管理或混交改造提供科学依据。通过对半干旱黄土丘陵区南泥湾林场8种典型纯林土壤腐殖质及其他性质进行系统检测,结果表明:(1)侧柏林土壤腐殖质含量最高(34.61 g/kg),腐殖化程度和稳定性一般;白榆和白桦林土壤的腐殖质含量中等(19.69—23.58 g/kg)、腐殖化程度和稳定性最佳;茶条槭和小叶杨林土壤的腐殖质含量(20.59—22.53 g/kg)和构成均为中等水平;油松、沙棘和刺槐林土壤的腐殖质质量较低(11.77—13.81 g/kg),且腐殖化程度较低,稳定性相对最差;(2)与胡敏酸含量存在显著相互促进作用(P<0.05)的土壤性质为CEC、N、微生物量和蛋白酶活性(相关系数0.769—0.926,下同),存在显著相互抑制作用的为有效Cu(-0.793);与富啡酸存在显著相互促进作用的为N、CEC、微生物量、蔗糖酶和磷酸酶活性(0.836—0.955),存在显著相互抑制作用的为有效Cu(-0.822);与胡敏素存在显著相互促进作用的为N、CEC、微生物量、磷酸酶活性和有效Zn(0.766—0.951),存在显著相互抑制作用的为脱氢酶活性(-0.784)。(3)腐殖质构成与其他性质的相关性均不显著(P>0.05),其中相对有利于提高胡敏酸/腐殖酸含量之比的土壤性质为蛋白酶、蔗糖酶和过氧化氢酶活性,而不利的是脱氢酶活性;相对有利于提高胡敏酸/富啡酸含量之比的为速效K、CEC和脲酶活性,而不利的是脱氢酶活性。(4)总体而言土壤腐殖质含量较之腐殖质构成与其他性质之间具有更大的相关性;向土壤增施N肥可以促进腐殖质的形成,增加K肥则有利于腐殖质构成的改善,而通过混交改造或增加林下植被是促进纯林土壤腐殖质化过程和解决土壤退化的根本措施。 | 张晓曦 刘增文 朱博超 邴塬皓 于齐 Luc Nhu Trung | 2015 | 生态学报2015，35，6： | 13 |
| 10 | 高温下自密实混凝土强度和变形性能试验研究显示文摘进行了不同温度下自密实混凝土、掺加聚丙烯纤维的自密实混凝土、高强混凝土的抗压强度及应力-应变曲线的非持荷试验研究,分析了抗压强度、应力-应变关系随温度的发展变化规律,基于试验结果给出了相应的应力-应变曲线方程,并与普通混凝土、高强、高性能混凝土研究成果进行了对比分析.为高温下自密实混凝土本构模型的建立奠定了基础,也为自密实混凝土结构的设计和分析提供了试验依据. | 陶津 柳献 袁勇 Luc Taerwe | 2009 | 同济大学学报(自然科学版)2009，37，6： | 11 |
| 11 | Going beyond 1000000 resolved points in a Brillouin distributed fiber sensor: theoretical analysis and experimental demonstration显示文摘Distributed fiber sensing possesses the unique ability to measure the distributed profile of an environmental quantity along many tens of kilometers with spatial resolutions in the meter or even centimeter scale.This feature enables distributed sensors to provide a large number of resolved points using a single optical fiber.However,in current systems,this number has remained constrained to a few hundreds of thousands due to the finite signal-to-noise ratio(SNR)of the measurements,which imposes significant challenges in the development of more performing sensors.Here,we propose and experimentally demonstrate an ultimately optimized distributed fiber sensor capable of resolving 2100000 independent points,which corresponds to a one-orderof-magnitude improvement compared to the state-of-the-art.Using a Brillouin distributed fiber sensor based on phase-modulation correlation-domain analysis combined with temporal gating of the pump and time-domain acquisition,a spatial resolution of 8.3 mm is demonstrated over a distance of 17.5 km.The sensor design addresses the most relevant factors impacting the SNR and the performance of medium-to-long range sensors as well as of sub-meter spatial resolution schemes.This step record in the number of resolved points could be reached due to two theoretical models proposed and experimentally validated in this study:one model describes the spatial resolution of the system and its relation with the sampling interval,and the other describes the amplitude response of the sensor,providing an accurate estimation of the SNR of the measurements. | Andrey Denisov Marcelo A Soto Luc Thévenaz | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 12 | Political connections and preferential access to finance: The role of campaign contributions显示文摘 | Stijn Claessens Erik Feijen Luc Laeven | 2007 | Journal of Financial Economics2007，，3： | 11 |
| 13 | Impacts of mixed litter decomposition from Robinia pseudoacacia and other tree species on C loss and nutrient release in the Loess Plateau of China显示文摘The productivity of Robinia pseudoacacia(R.p.) pure forest usually declines at the late growth stage,and reforming it into mixed forests could be a promising way to resolve this problem. When choosing a suitable tree species that can be mixed with R.p., the interspecific relationship is an important issue. Therefore, we gathered the autumn litter fall from R.p. and 10 other species from the Loess Plateau of China were mixed in dual species litterbags(R.p.+each other species) and buried them in soil for a 345 days lab decay incubation. We measured the litter mass loss and nutrient contents to determine whether the nutrient release was affected by mixed species litter decomposition. The impacts of mixed litter decomposition on macro-elements release were more obvious than on micro-elements. The litters with similar substrate quality might show variable impacts on nutrients release in mixed decomposition. The C loss and release of nutrient was improved by descending order when R.p. litter was mixed with Hippophae rhamnoides, Ulmus pumila, Populus simonii, Larix principis-rupprechtii and Quercus liaotungensis(Q.l.). But, except for Q.l., only the other species were recommended as suitable mix-plants for R.p. since promoting a high turnover of the nutrient in the litter compartment and a rapid availability for tree. | Xiaoxi Zhang Zengwen Liu Bochao Zhu Yuanhao Bing Nhu Trung Luc Liangzhen Du Zhenhua Zhu | 2016 | Journal of Forestry Research2016，27，3： | 10 |
| 14 | Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE显示文摘Multiple sclerosis(MS)is a chronic inflammatory disease of the central nervous system(CNS)in which the immune system damages the protective insulation surrounding the nerve fibers that project from neurons.A hallmark of MS and its animal model,experimental autoimmune encephalomyelitis(EAE),is autoimmunity against proteins of the myelin sheath.Most studies in this field have focused on the roles of CD4^(+)T lymphocytes,which form part of the adaptive immune system as both mediators and regulators in disease pathogenesis.Consequently,the treatments for MS often target the inflammatory CD4^(+)T-cell responses.However,many other lymphocyte subsets contribute to the pathophysiology of MS and EAE,and these subsets include CD8^(+)T cells and B cells of the adaptive immune system,lymphocytes of the innate immune system such as natural killer cells,and subsets of innate-like T and B lymphocytes such asγδT cells,natural killer T cells,and mucosal-associated invariant T cells.Several of these lymphocyte subsets can act as mediators of CNS inflammation,whereas others exhibit immunoregulatory functions in disease.Importantly,the efficacy of some MS treatments might be mediated in part by effects on lymphocytes other than CD4^(+)T cells.Here we review the contributions of distinct subsets of lymphocytes on the pathogenesis of MS and EAE,with an emphasis on lymphocytes other than CD4^(+)T cells.A better understanding of the distinct lymphocyte subsets that contribute to the pathophysiology of MS and its experimental models will inform the development of novel therapeutic approaches. | Luc Van Kaer Joshua L.Postoak Chuan Wang Guan Yang Lan Wu | 2019 | Cellular & Molecular Immunology2019，16，6： | 10 |
| 15 | 基于分布式光纤传感技术的堤坝渗流模拟系统设计(英文)显示文摘分析了堤坝渗流通过温度监测的可行性,提出了基于分布式光纤温度传感的堤坝渗流监测方法,设计了模拟装置;模拟监测系统由堤坝实体模型、渗流控制单元和光纤监测单元组成,采用传统的温湿度计和渗流量计对堤坝模型渗流实施单点监测,并与DiTeSt分析仪的结果比较。堤坝渗流模拟装置可实现不同水温、不同浸润线、不同规格堤坝和堤坝渗流程度的重复模拟,给出了一种野外专用的传感光缆实验结果。研究中的试验结果有利于设计合理的光缆布设和探测方案,同时为堤坝安全监测的量化研究提供有效的手段和平台。 | 朱萍玉 Luc Thévenaz 冷元宝 周杨 | 2007 | 仪器仪表学报2007，28，3： | 8 |
| 16 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 17 | Measuring Tourist’s Water Footprint in a Mountain Destination of Northwest Yunnan, China显示文摘Monitoring and minimizing tourist’s water consumption is essential for the sustainable development of mountain destinations in the world. However, available data and a generally accepted protocol on such measurement are still limited. This study uses water footprint accounting to quantify tourist’s water demand in the Liming valley, a World Heritage site and a rapidly growing tourism destination in Northwest Yunnan, China. Both the water for direct and indirect use is taken into account based on the consumptive behavior of the tourists in the valley. Data were collected through guesthouse monitoring and a tourist survey in the 2005 tourist season. The results indicate that an average tourist leaves behind a footprint of 5.2 m3 on local water resources per day. Food production and waste dilution are the two most important water consumption factors. The results also show tourists consume more water than the local residents on per capita basis. This suggests more commitment is necessary to cope with this stress by individual tourists. Management implications to make water use more sustainable in mountain destinations are derived from this study. | YANG Mingyu Luc HENS Robert DE WULF OU Xiaokun | 2011 | Journal of Mountain Science2011，8，5： | 7 |
| 18 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome. | Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang | 2015 | Molecular Plant2015，8，9： | 7 |
| 19 | 优化下肢慢性创面愈合中的技术应用:共识文件(译文)显示文摘目的:慢性创面处理中技术创新随处可见。尽管多种技术得到了广泛的应用,但并不总是能够确保创面愈合的结局。这份共识文件为创面标准化处理的相关诊疗技术应用提供了循证研究依据。 | Raj Mani Divid J.Margolis Vijay Shukla Sadanori Akita Miltos Lazarides Alberto Piaggesi Vincent Falanga Luc Teot 谢挺 付小兵 Marco Romanelli Chris Attinger 韩春茂 陆树良 Sylvie Meaume 许樟荣 Vijay Viswanathan 孙晓芳 肖娴 | 2017 | 感染.炎症.修复2017，18，2： | 7 |
| 20 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
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