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| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 3 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 4 | Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection显示文摘AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H. pylori ) infection. METHODS:This open randomized trial recruited 234 H. pylori positive gastritis patients from seven local centers. The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid , clarithromycin 500 mg bid , and amoxicillin 1000 mg bid ; OCA group, n = 79); two weeks of pre-treatment with probiotics, containing 3 × 107 Lactobacillus acidophilus per day, prior to one week of triple therapy (POCA group, n = 78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group, n = 77). Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy. Patients were asked to report associated symptoms at baseline and during follow-up, and side effects related to therapy were recorded. Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods. RESULTS:PP analysis involved 228 patients, 78 in the OCA, 76 in the POCA and 74 in the OCAP group. Successful eradication was observed in 171 patients; by PP analysis, the eradication rates were significantly higher (P = 0.007 each) in the POCA (62/76; 81.6%, 95% CI 72.8%-90.4%) and OCAP (61/74; 82.4%, 95% CI 73.6%-91.2%) groups than in the OCA group (48/78; 61.5%, 95% CI 50.6%-72.4%). ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5%, 95% CI 70.4%-88.6%) and OCAP (61/77; 79.2%, 95% CI 70%-88.4%) groups than in the OCA group (48/79; 60.8%, 95% CI 49.9%-71.7%), (P = 0.014 and P = 0.015). The symptom relieving rates in the POCA, OCAP and OCA groups were 85.5%, 89.2% and 87.2%, respectively. Only one of the 228 patients experienced an adverse reaction. CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H. pylori eradication rates. | Yi-Qi Du Tun Su Jian-Gao Fan Yu-Xia Lu Ping Zheng Xing-Hua Li Chuan-Yong Guo Ping Xu Yan-Fang Gong Zhao-Shen Li | 2012 | World Journal of Gastroenterology2012，18，43： | 54 |
| 5 | Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKβ显示文摘AIM: To investigate the effects and molecular mechanisms of berberine on improving insulin resistance induced by free fatty acids (FFAs) in 3T3-L1 adipocytes. METHODS: The model of insulin resistance in 3T3-L1 adipocytes was established by adding palmic acid (0.5 mmol/L) to the culture medium. Berberine treatment was performed at the same time. Glucose uptake rate was determined by the 2-deoxy-[3H]-D-glucose method. The levels of IkB kinase beta (IKKβ) Ser181 phosphorylation, insulin receptor substrate-1(IRS-1) Ser307 phosphorylation, expression of IKKβ, IRS-1, nuclear transcription factor kappaB p65 (NF-κB p65), phosphatidylinositol-3-kinase p85 (PI-3K p85) and glucose transporter 4 (GLUT4) proteins were detected by Western blotting. The distribution of NF-κB p65 proteins inside the adipocytes was observed through confocal laser scanning microscopy (CLSM). RESULTS: After the intervention of palmic acid for 24 h, the insulin-stimulated glucose transport in 3T3-L1 adipocytes was inhibited by 67%. Meanwhile, the expression of IRS-1 and PI-3K p85 protein was reduced, while the levels of IKKβ Ser181 and IRS-1 Ser307 phosphorylation, and nuclear translocation of NF-κB p65 protein were increased. However, the above indexes, which indicated the existence of insulin resistance, were reversed by berberine although the expression of GLUT4, IKKβ and total NF-κB p65 protein were not changed during this study. CONCLUSION: Insulin resistance induced by FFAs in 3T3-L1 adipocytes can be improved by berberine. Berberine reversed free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKβ. | Ping Yi Fu-Er Lu Li-Jun Xu Guang Chen Hui Dong Kai-Fu Wang | 2008 | World Journal of Gastroenterology2008，14，6： | 50 |
| 6 | Assessment of genetic diversity in broomcorn millet (Panicum miliaceum L.) using SSR markers显示文摘The genetic diversity of 118 accessions of broomcorn millet(Panicum miliaceum L.),collected from various ecological areas,was analyzed.Using 46 SSR(Simple Sequence Repeat) polymorphic markers from rice,wheat,oat and barley,a total of 226 alleles were found,which exhibited moderate level of diversity.The number of alleles per primer ranged from two to nine,with an average of 4.91.The range of polymorphism information content(PIC) was 0.284-0.980(average,0.793).The expected heterozygosity(He) varied from 0.346 to 0.989,with an average of 0.834.The average coefficient of the genetic similarity of SSR markers among the 118 accessions was 0.609,and it ranged from 0.461 to 0.851.The UPGMA(Unweight Pair Group Method with Arithmetic Mean) clustering analysis at the genetic similarity value of 0.609 grouped the 118 accessions into five groups.Mantel test meant that geographical origin and genetic distance presented positive correlation.The clustering results were consistent with known information on ecological growing areas.The genetic similarity coefficient of the accessions in the Loess Plateau ecotype was significantly lower than those in the other ecotypes.It indicates that the highest level of genetic diversity occurred in the Loess Plateau,which is probably the original site of Panicum miliaceum. | Xingyu Hu Jianfei Wang Ping Lu Hongsheng Zhang | 2009 | Journal of Genetics and Genomics2009，36，8： | 44 |
| 7 | Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas显示文摘 | Yu Hou Huahu Guo then Cao Xianlong Li Boqiang Hu Ping Zhu Xinglong Wu Lu Wen FuchouTang Yanyi Huang Jirun Peng | 2016 | Cell Research2016，26，3： | 48 |
| 8 | Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats显示文摘AIM: To investigate the anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium (DSS)-induced colitis of rats.METHODS: Acute colitis was induced by giving 2% DSS orally in drinking water for 8 d. Twenty-six male rats were randomized into oxymatrine-treated group (group A, 10rats), DSS control (group B, 10 rats) and normal control (group C, 6 rats). The rats in group A were injected from d 1 to 11 and drank 2% DSS solution from d 4 to 11.The rats in group B were treated with 0.9% saline in an equal volume as group A and drank 2% DSS solution from d 4 to 11. The rats in group C were treated with 0.9% saline as group B from d 1 to 11 and drank water normally. Diarrhea and bloody stool as well as colonic histology were observed. The levels of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined by ELISA, and nuclear factor-κB (NF-κB)activity and the expression of inter-cellular adhesion molecule-1 (ICAM-1) in colonic mucosa were detected by immunohistochernistry method.RESULTS: Compared with DSS control group, the inflammatory symptoms and histological damages of colonic mucosa in oxymatrine-treated group were significantly improved, the serum levels of TNF-α, IL-6, and the expression of NF-κB, ICAM-1 in colonic mucosa were significantly reduced.CONCLUSION: The fact that oxymatrine can reduce the serum levels of TNF-α, IL-6, and the expression of NF-κB and ICAM-1 in colonic mucosa in DSS-induced colitis of rats indicates that oxymatrine may ameliorate the colonic inflammation and thus alleviate diarrhea and bloody stool. | Ping Zheng Feng-Li Niu Wen-Zhong Liu Yao Shi Lun-Gen Lu | 2005 | World Journal of Gastroenterology2005，11，31： | 38 |
| 9 | Immunohistochemical study on p53,H-rasp21,c-erbB-2 protein and PCNA expression in HCC tissues of Hart and minority ethnic patients显示文摘AIM To find out the difference of humanprimary liver carcinogenesis between Han andminority ethnic patients in Xinjiang.METHODS Expression of p53,c-erbB-2,H-rasp21 protein and proliferating cell nuclearantigen(PCNA)in tumor tissues of 50 patients(Han 38,minority 12)with primary hepaticcarcinoma was detected byimmunohistochemistry(LSAB).RESULTS The positive frequency of p53,c-erbB-2,H-rasp21 and PCNA expression was46.0%(23/50),70.0%(35/50),68.0%(34/50)and 82.0%(41/50)in tumor tissues;4.0%(2/50),22.0%(11/50),64.0%(32/50)and 52.0%(26/ 50)in peritumors respectively and asignificant difference,except for H-rasp21,ofoncogene alteration was found(P<0.05)between tumor and non-tumorous tissues.Combined the three oncogenes alteration,26%(13/50)tumor tissues had positiveimmunoreactivity,but in peritumor and normallivers it was negative.The positive rate of p53,c-erbB-2 and H-rasp21 protein expression was39.5%(15/38),60.5%(23/38)and 39.5%(15/38)in tumors of Han patients;66.7%(8/12),100%(12/12)and 75.0%(9/12)in minoritiesrespectively,with statistical difference (P<0.05).CONCLUSION Overexpression of p53,c-erbB-2and H-rasp21 in human primary liver carcinoma isan important biomarker of genetic alteration.The different frequency of these oncogeneticchanges may reflect some environmental or/andethnic hereditary factors affecting the livercarcinogenesis.The special life style of Han,Uygur,Kazak and Mongolia nationalities inXinjiang may also be related to theetiopathogenesis of this disease. | Guo Yue Lin Zhao Lun Chen Cai Mo Lu Ying Li Xiao Jia Ping Rong Huang Department of Laboratory Medicine,Chinese PLA 474 Hospital,Urumqi 830011,Xinjiang Uygur Autonomic Region,China Department of Pathology,the 1st Teaching Hospital,Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomic Region,China | 2000 | World Journal of Gastroenterology2000，6，2： | 40 |
| 10 | 瑞芬太尼或舒芬太尼复合丙泊酚在患儿纤维支气管镜检查中的应用显示文摘目的比较瑞芬太尼或舒芬太尼复合丙泊酚用于患儿纤维支气管镜(FOB)检查时的临床效果。方法选择2016年7~8月在本院行FOB检查患儿60例,男37例,女23例,年龄2个月~14岁,体重3.5~45.5kg,ASAⅠ或Ⅱ级,按随机数字表法分为两组:瑞芬太尼组(R组)和舒芬太尼组(S组),每组30例。R组静脉注射瑞芬太尼0.5μg/kg、丙泊酚2.5~3.0mg/kg、咪达唑仑0.5mg;S组静脉注射舒芬太尼0.2μg/kg、丙泊酚2.5~3mg/kg、咪达唑仑0.5mg。记录患儿术中追加麻醉药物情况、纤维支气管镜检查时间及苏醒时间、内镜医师对麻醉效果满意度评分、患儿苏醒期躁动评分等。结果两组患儿丙泊酚消耗量、检查操作时间及苏醒时间差异均无统计学意义。检查过程中,S组躁动发生率(3.3%)明显低于R组(26.7%)(P〈0.05)。S组苏醒期躁动评分明显低于R组(P〈0.05);S组内镜医师对麻醉效果满意程度评分明显高于R组(P〈0.05)。结论瑞芬太尼或舒芬太尼复合丙泊酚可安全用于小儿FOB检查,舒芬太尼复合丙泊酚不良反应发生率更低,并可在一定程度上减轻苏醒期躁动,提高内镜医师对麻醉效果的满意程度。 | 孙茫 刘阳 于晴 涂真真 李上莹莹 涂生芬 ZHANG Ping MA Zongfen WANG Hongjuan LIU Lu | 2016 | 临床麻醉学杂志2016，32，10： | 36 |
| 11 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 12 | Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study显示文摘BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)imaging.However,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy tissue.This study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese patients.METHODS:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR imaging.MR imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded radiologists.The primary efficacy endpoint was sensitivity in lesion detection.RESULTS:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than 1cm.Gd-EOB-DTPA improved diagnostic accuracy in lesion classification.CONCLUSIONS:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 cm.Gd-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions. | Meng-Su Zeng Hui-Yi Ye Liang Guo Wei-Jun Peng Jian-Ping Lu Gao-Jun Teng Josy Breuer Yi Huan Ping Li Jian-Rong Xu Chang-Hong Liang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 31 |
| 13 | Fermented soybean meal improves the growth performance, nutrient digestibility, and microbial flora in piglets显示文摘In order to increase nutritive values of soybean meal(SBM), 3 species of microbes were used to ferment SBM. Through a 3 x 3 orthogonal design and parameter measurements of soybean peptide and antinutritional factor contents in the fermented soybean meal(FSBM), it was estimated that the best microbial proportion of Bacillus subtilis, Hansenula anomala and Lactobacillus casei was 2:1:2 for SBM fermentation(P < 0.05). The further piglet feeding experiment showed that 10% FSBM substitute for SBM had no significant effect on growth performance of suckling piglets(d 7-28)(P> 0.05). However, newlyweaned piglets(d 28-38) fed 10% FSBM and different levels of plasma protein obtained higher average daily gain(ADG) and feed conversion ratio(FCR), compared with those without FSBM but with 6% plasma protein(P < 0.05). Piglets(d 38-68) fed diets supplemented with FSBM and soybean protein concentrate(SBPC) at 3.75% and 7.5% respectively increased nutrient digestibility,fecal enzyme activity and lactic acid bacteria counts, and decreased fecal Escherichia coli counts(P < 0.05), compared with the control. These data indicated that FSBM had positive effects on nutrient digestibility and fecal microflora for piglets. | Lin Yuan Juan Chang Qingqiang Yin Min Lu Yuanran Di Ping Wang Zhixiang Wang Erzhu Wang Fushan Lu | 2017 | Animal Nutrition2017，，1： | 31 |
| 14 | Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats显示文摘AIM: To investigate the molecular mechanisms of berberine inhibition of hepatic gluconeogenesis in a diabetic rat model.METHODS: The 40 rats were randomly divided into five groups. One group was selected as the normal group. In the remaining groups(n = 8 each), the rats were fed on a high-fat diet for 1 mo and received intravenous injection of streptozotocin for induction of the diabetic models. Berberine(156 mg/kg per day)(berberine group) or metformin(184 mg/kg per day)(metformin group) was intragastrically administered to the diabetic rats and 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside(AICAR)(0.5 mg/kg per day)(AICAR group) was subcutaneously injected to the diabetic rats for 12 wk. The remaining eight diabetic rats served as the model group. Fasting plasma glucose and insulin levels as well as lipid profile were tested.The expressions of proteins were examined by western blotting. The nuclear translocation of CREB-regulated transcription co-activator(TORC)2 was observed by immunohistochemical staining. RESULTS: Berberine improved impaired glucose tolerance and decreased plasma hyperlipidemia. Moreover, berberine decreased fasting plasma insulin and homeostasis model assessment of insulin resistance(HOMA-IR). Berberine upregulated protein expression of liver kinase(LK)B1, AMP-activated protein kinase(AMPK) and phosphorylated AMPK(p-AMPK). The level of phophorylated TORC2(p-TORC2) protein in the cytoplasm was higher in the berberine group than in the model group, and no significant difference in total TORC2 protein level was observed. Immunohistochemical staining revealed that more TORC2 was localized in the cytoplasm of the berberine group than in the model group. Moreover, berberine treatment downregulated protein expression of the key gluconeogenic enzymes(phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) in the liver tissues. CONCLUSION: Our findings revealed that berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway. | Shu-Jun Jiang Hui Dong Jing-Bin Li Li-Jun Xu Xin Zou Kai-Fu Wang Fu-Er Lu Ping Yi | 2015 | World Journal of Gastroenterology2015，21，25： | 33 |
| 15 | Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells显示文摘定序技术的单个房间的 epigenome 最近被开发了。然而,在一个单个房间定序的 epigenome 的不同的层的联合还没被完成了。这里,我们开发了定序能分析染色质的技术(单个房间的 COOL-seq ) 的单个房间的 multi-omics 放的 state/nucleosome, DNA methylation,拷贝数字变化和 ploidy 同时从一样的单个哺乳动物的房间。我们使用了这个方法在老鼠 preimplantation 胚胎分析染色质状态和 DNA methylation 的 reprogramming。我们发现了那在以内 < 授精的 12 h,每个单个房间和母亲、父亲的染色体的快速、全球的 reprogramming 经历全球染色体 demethylation 到一个高度打开的染色质状态。这被减少的坦诚在迟了的接合子阶段以后跟随。而且,从迟了的接合子上演到 4 房间,剩余 DNA methylation 优先地在各单个的分裂球在父亲的等位基因的 intergenic 区域和母亲的等位基因的 intragenic 区域上被保存。然而,染色质可接近性在在从迟了的接合子的每个单个房间的父亲、母亲的等位基因之间是类似的到胚囊阶段。几个 pluripotency 管理者的有约束力的主题在远侧的 nucleosome 被充实弄空的区域从象 2 房间阶段一样早。这显示如此的目标基因的 cis 规章的元素从 2 房间阶段被告知到一个开的状态向前,在 pluripotency 最后在胚囊的 ICM 被建立以前,渴望。基因可以被分类进同类地开,同类地关门了并且分叉的状态基于他们在单个房间之中的倡导者区域的染色质可接近性。这能在 preimplantation 开发期间被跟踪到逐步的转变。我们的学习在早老鼠胚胎在单个底的分辨率提供染色体规模染色质状态和 DNA methylation 动力学的第一单个房间、父母的等位基因特定的分析并且提供新卓见进异构还高度在这个过程期间订了 epigenomic reprogramming 的特征。 | Fan Guo Lin Li Jingyun Li Xinglong Wu Boqiang Hu Ping Zhu Lu Wen Fuchou Tang | 2017 | Cell Research2017，27，8： | 34 |
| 16 | Survey of convex optimization for aerospace applications显示文摘Convex optimization is a class of mathematical programming problems with polynomial complexity for which state-of-the-art, highly efficient numerical algorithms with predeterminable computational bounds exist. Computational efficiency and tractability in aerospace engineering, especially in guidance, navigation, and control (GN&C), are of paramount importance. With theoretical guarantees on solutions and computational efficiency, convex optimization lends itself as a very appealing tool. Coinciding the strong drive toward autonomous operations of aerospace vehicles, convex optimization has seen rapidly increasing utility in solving aerospace GN&C problems with the potential for onboard real-time applications. This paper attempts to provide an overview on the problems to date in aerospace guidance, path planning, and control where convex optimization has been applied. Various convexification techniques are reviewed that have been used to convexify the originally nonconvex aerospace problems. Discussions on how to ensure the validity of the convexification process are provided. Some related implementation issues will be introduced as well. | Xinfu Liu Ping Lu Binfeng Pan | 2017 | Astrodynamics2017，1，1： | 32 |
| 17 | Phosphate removal from wastewater by model-La(Ⅲ)zeolite adsorbents显示文摘Phosphorus is one of the primary nutrients which leads to eutrophication and accelerates aging process in enclosed water bodies. Because of the poor phosphorus selectivity of other adsorbents, the novel La(III)-modified zeolite adsorbent (LZA) was prepared by modifying 90 nm zeolite with lanthanide to selectively remove phosphate in the presence of various omnipresent anions, such as sulfates, bicarbonates, and chlorides. Through batch and fixed bed operation, the following optimum conditions were obtained: concentration of lanthanum chloride solution 0.05 mol/L; solid/liquor ratio 1/25; pH 10; calcination temperature 550°C; time 1 h. The value of the Freundlich model constants Kf and 1/n were found to be 16.76 mg/L and 0.2209, respectively. In addition, when calculated at pH 6.0, distribution coefficient KD could be as high as 36.6. Furthermore, in the alkaline pH range, solution of 0.8 mol/L NaCl was used to regenerate the saturated LZA, which could reach the high regeneration efficiency as high as 100%. Because of the good selectivity and regenerability of LZA, it might serve as a potential way for advanced phosphate removal from the sewage containing other anions. | NING Ping BART Hans-Jorg LI Bing LU Xiwu ZHANG Yong | 2008 | Journal of Environmental Sciences2008，20，6： | 30 |
| 18 | Adventitious root formation in rice requires OsGNOM1 and is mediated by the OsPINs family显示文摘在谷物的含纤维的根系统包括首先偶然根(艺术) ,它在营养素和水举起起重要作用。关于位于 AR 开发下面的分子的机制的当前的知识仍然是有限的。我们这里报导四米饭(Oryza sativa L.) 的隔离异种从不同基因背景,所有哪个在 AR 是有缺点的形成。这些异种展出了侧面的根(LR ) 和 gravitropism 的部分损失的减少的数字。也显示的异种提高了敏感到 N-1-naphthylphthalamic 酸,极的植物生长素运输的一个禁止者(轻拍) ,显示变化影响了植物生长素运输。用四异种之一的位置的克隆表明它被一个 guanine 核苷酸交换因素的 loss-of-function 为 ADP-ribosylation 因素(OsGNOM1 ) 引起。转基因的植物显示出的 promoter::GUS 的 RT-PCR 和分析那 OsGNOM1 在 AR primordia,脉管的纸巾, LR,根尖端,叶子,花药和词根静脉被表示,与类似于植物生长素的一个分发模式。另外, OsPIN2, OsPIN5b 和 OsPIN9 的表情在异种被改变。一起拿,这些调查结果显示 OsGNOM1 通过调整影响艺术的形成轻拍。 | Shiping Liu Jirong Wang Lu Wang Xiaofei Wang Yanhong Xue Ping Wu Huixia Shou | 2009 | Cell Research2009，19，9： | 29 |
| 19 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 20 | PVT v2:Improved baselines with Pyramid Vision Transformer显示文摘Transformers have recently lead to encouraging progress in computer vision.In this work,we present new baselines by improving the original Pyramid Vision Transformer(PVT v1)by adding three designs:(i)a linear complexity attention layer,(ii)an overlapping patch embedding,and(iii)a convolutional feed-forward network.With these modifications,PVT v2 reduces the computational complexity of PVT v1 to linearity and provides significant improvements on fundamental vision tasks such as classification,detection,and segmentation.In particular,PVT v2 achieves comparable or better performance than recent work such as the Swin transformer.We hope this work will facilitate state-ofthe-art transformer research in computer vision.Code is available at http://gffzz188fe103f8f1460asn5xwfqc6kx906nfv.ffgz.tsg.suse.edu.cn/whai362/PVT. | Wenhai Wang Enze Xie Xiang Li Deng-Ping Fan Kaitao Song Ding Liang Tong Lu Ping Luo Ling Shao | 2022 | Computational Visual Media2022，8，3： | 30 |
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