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| 1 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 2 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 3 | Nurrsing adherence with evidence - based guidelines for preventing ventilator - associated pneumonia显示文摘 | Ricart M Lorente C Diaz E | 2003 | Crit Care Med2003，31，11： | 1 |
| 4 | An improved method to recover saliva from human skin:the double swab technique显示文摘 | Lorente M Lorente J A | 1997 | J Forensic Sci1997，42，： | 1 |
| 5 | Continuous endotracheal tube cuff pressure control system protects against ventilator-associated pneumonia显示文摘 | Lorente L Lecuona M Jimenez A | 2014 | Crit Care2014，18，2： | 1 |
| 6 | The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells显示文摘 | Carraeedo A Lorente M Egia A | 2006 | Cancer Cell2006，9，4： | 1 |
| 7 | Bacterial filters in respiratory circuits:an unnecessary cost?显示文摘 | Lorente L Lecuona M Malaga J | 2003 | Crit Care Med2003，31，8： | 1 |
| 8 | Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia显示文摘 | Lorente L Lecuona M Jimenez A | 2007 | Am J Respir Crit Care Med2007，176，11： | 1 |
| 9 | Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia显示文摘 | Lorente L Lecuona M Jiménez A | 2007 | Am J Respir Crit Care Med2007，176，： | 1 |
| 10 | Helieobaeter pylori stimulates pepsinogens secretion from isolated human peptic cells显示文摘 | Lorente S Doiz O Trinidad Serrano M | 2002 | Gut2002，50，： | 1 |
| 11 | An improved method to recover saliva from human skin: the double swab technique 显示文摘 | Sweet D Lorente M Lorente JA | 1997 | J Forensic Sei1997，42，2： | 1 |
| 12 | Exocrine pancreas development in zebrafish 显示文摘 | YEE N S LORENT K PACK M | 2005 | Dev Bio12005，284，： | 1 |
| 13 | Network of channels for self-healing composite materials 显示文摘 | Bejan A Lorente S Wang K M | 2006 | Journal of Applied Physics2006，100，03： | 1 |
| 14 | Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia 显示文摘 | Lorente L Lecuona M Jimenez A | 2007 | Am J Respir Crit Care Med2007，176，11： | 1 |
| 15 | A combined preclinical therapy of cannabinoids and temozolomide against glioma 显示文摘 | Tortes S Lorente M Rodriguez Fomas F | 2011 | Molecular Cancer Therapeutics2011，10，1： | 1 |
| 16 | Central venous catheter -related infection in a prospective and observational study of 2,595 catheters 显示文摘 | Lorente L Henry C Martin M M | 2005 | Crit Care2005，9，6： | 1 |
| 17 | A hybrid recommender system for the selective dissemination of research resources in a Technology Transfer Office显示文摘 | Porcel C Tejeda Lorente A Martinez M A Herrera Viedma E | 2012 | Information Sciences2012，184，1： | 1 |
| 18 | Vascularized networks with two optimized channels sizes 显示文摘 | Wang K M Lorente S Bejan A | 2006 | Journal of Physics D : Applied Physics2006，39，： | 1 |
| 19 | Influence of endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia显示文摘 | Lorente L Lecuona M Jim-nez A | 2007 | Am Bespirait Care bled2007，176，11： | 1 |
| 20 | Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action显示文摘 | LORENTE M TORRES S SALA7AR M | 2011 | Cell Death Differ2011，18，6： | 1 |
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