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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 3 | Hierarchical selfassembly of metal nanostructures on diblock copolymer scaffolds显示文摘 | LOPES W A JAEGER H M | 2001 | Nature2001，414，6865： | 1 |
| 4 | Data mining with an ant colony optimization algorithm显示文摘 | Parpinelli R S Lopes H S Freitas A A | 2002 | IEEE Trans Evolutionary Compute2002，6，4： | 1 |
| 5 | Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators显示文摘 | Du X Zhang H Lopes C | 2004 | J Biol Chem2004，279，37： | 1 |
| 6 | Gastric Cancer Surgery in Elderly Patients显示文摘 | Stephen Gretschel MD Lope Estevez-Schwarz MD Michael Hünerbein MD Ulrike Schneider MD Peter M. Schlag MD PhD | 2006 | World Journal of Surgery2006，，8： | 1 |
| 7 | Contribution of intraopertive electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985-96) and with (1996-2003) functional mapping in the same institution显示文摘 | Duffau H Lopes M Arthuis F | 2005 | I Neurol Neurosurg Psychiatry2005，76，6： | 1 |
| 8 | sensilla basiconica and their detaction eucalyptus woodborer, Phoracantha ( Coleoptera: Cerambycidae ) 显示文摘 | Lopes O Barata EN Mustaparta H | 2002 | Development2002，31，1： | 1 |
| 9 | Adding protein context to the human protein -protein interaction network to reveal meaningful inter- actions显示文摘 | SCHAEFER M H LOPES T J S MAH N et at | 2013 | PLoS Comput Biol2013，9，10： | 1 |
| 10 | Islands of Runaway Electrons in the TEXTOR T-okamak and Relation to Transport in a Stochastic Field显示文摘 | Jaspers R Lopes Cardozo N J Finken K H | 1994 | Phys Rev Lett1994，，26： | 1 |
| 11 | Bio-oils upgrading for second generation biofuels显示文摘 | Graca I Lopes J M Cerqueira H S | | 0，，： | 1 |
| 12 | Characteristic interactions with phosphatidylinositol4,5-bisphosphate determine regulation of Kir channels by diverse modulators 显示文摘 | Du X N Zhang H L Lopes C | 2004 | J Biol Chem2004，279，37： | 1 |
| 13 | Performance assessment of active frequency drifting islanding detection methods显示文摘 | Lopes L A C Sun H | 2006 | IEEE Transactions on Energy Conversion2006，21，1： | 1 |
| 14 | The utility of MPEG-7 systems in audio-visual applications with multiple streams显示文摘 | Lopes R J Lindsay A T David H | 2003 | IEEE Transactions on Circuits and Systems for Video Technology2003，13，1： | 1 |
| 15 | Event-related EEG/MEG synchronization and desychronization: basic principles 显示文摘 | Pfurtscheller G Lopes da Silva F H | 1999 | Clinical Neurophysiology1999，110，11： | 1 |
| 16 | Symp tomatic retrograde arterial thrombosis A rare complication af ter microsurgical removal of cerebral arteriovenous malforma tions显示文摘 | Costa B L Faria M H G Lopes J L | 2013 | Clinical Neurology and Neurosurgery2013，115，： | 1 |
| 17 | Human rhinovirus and disease severity in children 显示文摘 | Costa LF Queir6z DA Lopes da Silveira H | 2014 | Pediatrics2014，133，2： | 1 |
| 18 | Liftoff insensitive thickness measurement of aluminum plates using harmonic eddy current excitation and a GMR sensor显示文摘 | Ribeiro A Lopes Ramos H | 2012 | Measurement2012，45，9： | 1 |
| 19 | Communication during downsizing of a telecommunications company 显示文摘 | Appelbaum S H Lopes R Audet L | 2003 | Corporate Communications: An International Journal2003，8，2： | 1 |
| 20 | Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats 显示文摘 | Nakano H Colli BO Lopes Lda S | 2007 | Arq Neuropsiquiatr2007，65，3： | 1 |
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