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| 1 | Challenges and prospects for consumer acceptance of cultured meat显示文摘Consumer acceptance of cultured meat is expected to depend on a wide diversity of determinants ranging from technologyrelated perceptions to product-specific expectations, and including wider contextual factors like media coverage, public involvement, and trust in science, policy and society. This paper discusses the case of cultured meat against this multitude of possible determinants shaping future consumer acceptance or rejection. The paper also presents insights from a primary exploratory study performed in April 2013 with consumers from Flanders(Belgium)(n=180). The concept of cultured meat was only known(unaided) by 13% of the study participants. After receiving basic information about what cultured meat is, participants expressed favorable expectations about the concept. Only 9% rejected the idea of trying cultured meat, while two thirds hesitated and about quarter indicated to be willing to try it. The provision of additional information about the environmental benefits of cultured meat compared to traditional meat resulted in 43% of the participants indicating to be willing to try this novel food, while another 51% indicated to be ‘maybe' willing to do so. Price and sensory expectations emerged as major obstacles. Consumers eating mostly vegetarian meals were less convinced that cultured meat might be healthy, suggesting that vegetarians may not be the ideal primary target group for this novel meat substitute. Although exploratory rather than conclusive, the findings generally underscore doubts among consumers about trying this product when it would become available, and therefore also the challenge for cultured meat to mimic traditional meat in terms of sensory quality at an affordable price in order to become acceptable for future consumers. | Wim Verbeke Pierre Sans Ellen J Van Loo | 2015 | Journal of Integrative Agriculture2015，14，2： | 10 |
| 2 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | A diffusion-kinetic model for predicting solder/conductor interactions in high density interconnections 显示文摘 | RONKA K J VAN LOO F J J KIVILAHTI J K | 1998 | Metall Trans A1998，29，12： | 1 |
| 4 | Preparation and molecular structure of polyvinyl alcohol by low temperature bulk polymerization of vinyl acetate and saponification显示文摘 | Loo W S Lee C J | 2000 | Int J PolymerMater2000，46，12： | 1 |
| 5 | Cubic AgPb, SbTez+,, : bulk thermoelectric materials with high figure of merit 显示文摘 | Hsu K F Loo S Guo F Chen W Dyck J S Uher C Hogan T Polychroniadis E K Kanatzidis M G | 2004 | Science2004，303，： | 1 |
| 6 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 7 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 8 | Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging 显示文摘 | Alfons S K de Hooqe Fons A J van de Loo | 2005 | Osteoarth Cartilage2005，13，1： | 1 |
| 9 | Irinotecan pharmacokinetics pharmacodynamicsthe clinical relevance of prolonged exposure to SN-38显示文摘 | Mathijssen RHJ Verweij J Loos WJ | 2002 | Br J Cancer2002，87，： | 1 |
| 10 | Induction of B7-1in podocytes is associated with nephritic syndrome显示文摘 | Reiser J yon Gersdorff G Loos M | 2004 | J Clin Invest2004，113，10： | 1 |
| 11 | Gas-phase coordination properties of Zn^2+ Cu^2+ Ni^2+ and Co^2+ with histidine-eontaining peptides显示文摘 | Hu P Loo J A | 1995 | J Am Chem Soc1995，117，11： | 1 |
| 12 | Activation of ribu- lose - 1, 5 - bisphosphate carboxyiase/oxygenase (Rubisco) involves Rubisco activase Trpl6 显示文摘 | VAN DE LOO F J SALVUCCI M E | 1996 | Bio- chemistry1996，35，25： | 1 |
| 13 | Con- sumers' willingness to pay for organic chicken breast: evi- dence from choice experiment显示文摘 | VAN LOO E J CAPUTO V NAYGA J R M | 2011 | Food Quality and Prefer- ence2011，22，7： | 1 |
| 14 | Human metabolic phenotype diversity and its association with diet and blood pressure显示文摘 | Holmes E Loo R L Stamler J | 2008 | Nature2008，453，7193： | 1 |
| 15 | Irinotecan pharmacokinetics-pharmacodynamics:the clinical relevance of prolonged exposure to SN-38显示文摘 | Mathijssen RH Verweij J Loos WJ | 2002 | Br J Cancer2002，87，2： | 1 |
| 16 | Dietary modulation of the human colonic microbiota:updating the concept of prebiotics显示文摘 | GIBSON G R PROBERT H M VAN LOO J | 2004 | Nutrition Research Reviews2004，17，2： | 1 |
| 17 | Recent advances in radio resource management for heterogeneous LTE/LTE-A networks 显示文摘 | Ying L L Chuah T C Loo J | 2014 | IEEE Communications Surveys & Tutorials2014，16，4： | 1 |
| 18 | Practical approach to the prediction of rutting in asphalt pavements:the SHELL method显示文摘 | van de LOO P J | 1976 | Journal of the Transportation Research Board1976，616，： | 1 |
| 19 | Nanoscale morphology of high-performance polymer solar cells显示文摘 | Yang X N Loos J Veenstra S C | 2005 | Nano Lett2005，5，： | 1 |
| 20 | 显示文摘 | Grossiord N Loos J Regev O | 2006 | Chemistry of Materials2006，18，： | 1 |
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